Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease
Abstract Previous studies showed that injection of tissue extracts containing amyloid-β (Aβ) aggregates accelerate amyloid deposition in the brain of mouse models of Alzheimer’s disease (AD) through prion-like mechanisms. In this study, we evaluated whether brain amyloidosis could be accelerated by...
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| Format: | Article |
| Language: | English |
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BMC
2020-12-01
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| Series: | Acta Neuropathologica Communications |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40478-020-01087-1 |
| _version_ | 1819276531465191424 |
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| author | Rodrigo Morales Claudia Duran-Aniotz Javiera Bravo-Alegria Lisbell D. Estrada Mohammad Shahnawaz Ping-Ping Hu Carlos Kramm Diego Morales-Scheihing Akihiko Urayama Claudio Soto |
| author_facet | Rodrigo Morales Claudia Duran-Aniotz Javiera Bravo-Alegria Lisbell D. Estrada Mohammad Shahnawaz Ping-Ping Hu Carlos Kramm Diego Morales-Scheihing Akihiko Urayama Claudio Soto |
| author_sort | Rodrigo Morales |
| collection | DOAJ |
| description | Abstract Previous studies showed that injection of tissue extracts containing amyloid-β (Aβ) aggregates accelerate amyloid deposition in the brain of mouse models of Alzheimer’s disease (AD) through prion-like mechanisms. In this study, we evaluated whether brain amyloidosis could be accelerated by blood infusions, procedures that have been shown to transmit prion diseases in animals and humans. Young transgenic mice infused with whole blood or plasma from old animals with extensive Aβ deposition in their brains developed significantly higher levels brain amyloidosis and neuroinflammation compared to untreated animals or mice infused with wild type blood. Similarly, intra-venous injection of purified Aβ aggregates accelerated amyloid pathology, supporting the concept that Aβ seeds present in blood can reach the brain to promote neuropathological alterations in the brain of treated animals. However, an amyloid-enhancing effect of other factors present in the blood of donors cannot be discarded. Our results may help to understand the role of peripheral (amyloid-dependent or -independent) factors implicated in the development of AD and uncover new strategies for disease intervention. |
| first_indexed | 2024-12-23T23:41:42Z |
| format | Article |
| id | doaj.art-0abd87e9c0524d7d9af4eb8a1dead7ab |
| institution | Directory Open Access Journal |
| issn | 2051-5960 |
| language | English |
| last_indexed | 2024-12-23T23:41:42Z |
| publishDate | 2020-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Acta Neuropathologica Communications |
| spelling | doaj.art-0abd87e9c0524d7d9af4eb8a1dead7ab2022-12-21T17:25:37ZengBMCActa Neuropathologica Communications2051-59602020-12-018111610.1186/s40478-020-01087-1Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s diseaseRodrigo Morales0Claudia Duran-Aniotz1Javiera Bravo-Alegria2Lisbell D. Estrada3Mohammad Shahnawaz4Ping-Ping Hu5Carlos Kramm6Diego Morales-Scheihing7Akihiko Urayama8Claudio Soto9Mitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, The University of Texas Medical School at HoustonMitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, The University of Texas Medical School at HoustonMitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, The University of Texas Medical School at HoustonFacultad de Ciencias de la Salud, Universidad Bernardo O’HigginsMitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, The University of Texas Medical School at HoustonMitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, The University of Texas Medical School at HoustonMitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, The University of Texas Medical School at HoustonMitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, The University of Texas Medical School at HoustonMitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, The University of Texas Medical School at HoustonMitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, The University of Texas Medical School at HoustonAbstract Previous studies showed that injection of tissue extracts containing amyloid-β (Aβ) aggregates accelerate amyloid deposition in the brain of mouse models of Alzheimer’s disease (AD) through prion-like mechanisms. In this study, we evaluated whether brain amyloidosis could be accelerated by blood infusions, procedures that have been shown to transmit prion diseases in animals and humans. Young transgenic mice infused with whole blood or plasma from old animals with extensive Aβ deposition in their brains developed significantly higher levels brain amyloidosis and neuroinflammation compared to untreated animals or mice infused with wild type blood. Similarly, intra-venous injection of purified Aβ aggregates accelerated amyloid pathology, supporting the concept that Aβ seeds present in blood can reach the brain to promote neuropathological alterations in the brain of treated animals. However, an amyloid-enhancing effect of other factors present in the blood of donors cannot be discarded. Our results may help to understand the role of peripheral (amyloid-dependent or -independent) factors implicated in the development of AD and uncover new strategies for disease intervention.https://doi.org/10.1186/s40478-020-01087-1Amyloid-betaBlood transfusionPrions |
| spellingShingle | Rodrigo Morales Claudia Duran-Aniotz Javiera Bravo-Alegria Lisbell D. Estrada Mohammad Shahnawaz Ping-Ping Hu Carlos Kramm Diego Morales-Scheihing Akihiko Urayama Claudio Soto Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease Acta Neuropathologica Communications Amyloid-beta Blood transfusion Prions |
| title | Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease |
| title_full | Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease |
| title_fullStr | Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease |
| title_full_unstemmed | Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease |
| title_short | Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease |
| title_sort | infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of alzheimer s disease |
| topic | Amyloid-beta Blood transfusion Prions |
| url | https://doi.org/10.1186/s40478-020-01087-1 |
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