IL-6/JAK2-dependent G6PD phosphorylation promotes nucleotide synthesis and supports tumor growth

IL-6/JAK2-dependent G6PD phosphorylation promotes nucleotide synthesis and supports tumor growth

Objective: Tumor cells hijack inflammatory mechanisms to promote their own growth. IL-6 is one of the major cytokines, and is frequently upregulated in tumors. The pentose phosphate pathway (PPP) generates the indispensable building blocks to produce various nucleotides. Here we aimed to determine w...

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Bibliographic Details
Main Authors: Xuemei Qiu, Hongping Ye, Xiaofei Li, Dan Li, Lu Jiang, Rui Liu, Zhe Zhao, Dan He
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Molecular Metabolism
Subjects:
G6PD
JAK2
Nucleotide metabolism
Pentose phosphate pathway
Tumorigenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877823001709

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