Network connectivity and local transcriptomic vulnerability underpin cortical atrophy progression in Parkinson’s disease

Network connectivity and local transcriptomic vulnerability underpin cortical atrophy progression in Parkinson’s disease

Parkinson’s disease pathology is hypothesized to spread through the brain via axonal connections between regions and is further modulated by local vulnerabilities within those regions. The resulting changes to brain morphology have previously been demonstrated in both prodromal and de novo Parkinson...

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Bibliographic Details
Main Authors: Andrew Vo, Christina Tremblay, Shady Rahayel, Golia Shafiei, Justine Y. Hansen, Yvonne Yau, Bratislav Misic, Alain Dagher
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:NeuroImage: Clinical
Subjects:
Parkinson’s disease
Structural MRI
Cortical thinning
Connectomics
Imaging transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158223002140

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