TCF7L2 rs7903146 polymorphism modulates the association between adherence to a Mediterranean diet and the risk of gestational diabetes mellitus
Objective: There is sparse evidence for the impact of gene-diet interaction on gestational diabetes mellitus (GDM) onset. Recent findings have shown that late first-trimester high adherence to a Mediterranean diet (MedDiet) pattern is associated with a GDM risk reduction. The aim of this study was t...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | Metabolism Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589936820300499 |
| _version_ | 1819076591673671680 |
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| author | Ana Barabash Johanna D. Valerio Nuria Garcia de la Torre Inés Jimenez Laura del Valle Verónica Melero Carla Assaf-Balut Manuel Fuentes Elena Bordiu Alejandra Durán Miguel A. Herraiz Nuria Izquierdo María J. Torrejón Paz de Miguel Isabelle Runkle Miguel A. Rubio Alfonso L. Calle-Pascual |
| author_facet | Ana Barabash Johanna D. Valerio Nuria Garcia de la Torre Inés Jimenez Laura del Valle Verónica Melero Carla Assaf-Balut Manuel Fuentes Elena Bordiu Alejandra Durán Miguel A. Herraiz Nuria Izquierdo María J. Torrejón Paz de Miguel Isabelle Runkle Miguel A. Rubio Alfonso L. Calle-Pascual |
| author_sort | Ana Barabash |
| collection | DOAJ |
| description | Objective: There is sparse evidence for the impact of gene-diet interaction on gestational diabetes mellitus (GDM) onset. Recent findings have shown that late first-trimester high adherence to a Mediterranean diet (MedDiet) pattern is associated with a GDM risk reduction. The aim of this study was to investigate if this effect could be modulated by TCF7L2 rs7903146 polymorphism.Research design and methods: A total of 874 pregnant women participants in the St Carlos GDM prevention study, were stratified into three groups defined as “High,5–6 on targets”, “Moderate, 2–4 on targets” or “Low, 0–1 on targets” adherence to Mediterranean diet according to late first-trimester compliance with six food targets: >12 servings/week of vegetables, >12 pieces/week of fruits, <2 servings/week of juice, >3 servings/week of nuts, >6 days/week and >40 mL/day consumption of extra virgin olive oil. All patients were genotyped for rs7903146 using Taqman technology. Results: Logistic regression analysis revealed that the risk of developing GDM in those with high adherence versus low adherence was significantly reduced only in carriers of the T-allele (CT + TT), with an adjusted odds ratio of 0.15 (95% CI:0.05–0.48). This effect was not observed in CC carriers. Interaction analysis yielded significant rs7903146-MedDiet interaction in GDM risk (p < 0.03) Conclusions: Women carrying the rs7903146 T-allele who highly adhere to a MedDiet early in pregnancy have lower risk of developing GDM than CC carriers. This reinforces the importance of identifying patients at risk of GDM who would be especially sensitive to nutritional interventions based on their genetic characteristics. |
| first_indexed | 2024-12-21T18:43:45Z |
| format | Article |
| id | doaj.art-0ac22cd44dec4c43b16007f63d2c791c |
| institution | Directory Open Access Journal |
| issn | 2589-9368 |
| language | English |
| last_indexed | 2024-12-21T18:43:45Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Metabolism Open |
| spelling | doaj.art-0ac22cd44dec4c43b16007f63d2c791c2022-12-21T18:53:56ZengElsevierMetabolism Open2589-93682020-12-018100069TCF7L2 rs7903146 polymorphism modulates the association between adherence to a Mediterranean diet and the risk of gestational diabetes mellitusAna Barabash0Johanna D. Valerio1Nuria Garcia de la Torre2Inés Jimenez3Laura del Valle4Verónica Melero5Carla Assaf-Balut6Manuel Fuentes7Elena Bordiu8Alejandra Durán9Miguel A. Herraiz10Nuria Izquierdo11María J. Torrejón12Paz de Miguel13Isabelle Runkle14Miguel A. Rubio15Alfonso L. Calle-Pascual16Endocrinology and Nutrition Department. Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, SpainEndocrinology and Nutrition Department. Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, SpainEndocrinology and Nutrition Department. Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, SpainEndocrinology and Nutrition Department. Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, SpainEndocrinology and Nutrition Department. Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, SpainEndocrinology and Nutrition Department. Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, SpainEndocrinology and Nutrition Department. Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, SpainPreventive Medicine Department. Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del University Hospital Clínico San Carlos (IdISSC), Madrid, SpainEndocrinology and Nutrition Department. Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain; Medicina 2 Department, Facultad de Medicina, Universidad Complutense de Madrid, SpainEndocrinology and Nutrition Department. Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain; Medicina 2 Department, Facultad de Medicina, Universidad Complutense de Madrid, SpainGynecology and Obstetrics Department. Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, SpainGynecology and Obstetrics Department. Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, SpainClinical Laboratory Department. Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, SpainEndocrinology and Nutrition Department. Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain; Medicina 2 Department, Facultad de Medicina, Universidad Complutense de Madrid, SpainEndocrinology and Nutrition Department. Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain; Medicina 2 Department, Facultad de Medicina, Universidad Complutense de Madrid, SpainEndocrinology and Nutrition Department. Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain; Medicina 2 Department, Facultad de Medicina, Universidad Complutense de Madrid, SpainEndocrinology and Nutrition Department. Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain; Medicina 2 Department, Facultad de Medicina, Universidad Complutense de Madrid, Spain; Corresponding author. Hospital Clínico San Carlos, Endocrinology and Nutrition Department, Martin Lagos s/n, 1a Sur, E-28040, Madrid, Spain.Objective: There is sparse evidence for the impact of gene-diet interaction on gestational diabetes mellitus (GDM) onset. Recent findings have shown that late first-trimester high adherence to a Mediterranean diet (MedDiet) pattern is associated with a GDM risk reduction. The aim of this study was to investigate if this effect could be modulated by TCF7L2 rs7903146 polymorphism.Research design and methods: A total of 874 pregnant women participants in the St Carlos GDM prevention study, were stratified into three groups defined as “High,5–6 on targets”, “Moderate, 2–4 on targets” or “Low, 0–1 on targets” adherence to Mediterranean diet according to late first-trimester compliance with six food targets: >12 servings/week of vegetables, >12 pieces/week of fruits, <2 servings/week of juice, >3 servings/week of nuts, >6 days/week and >40 mL/day consumption of extra virgin olive oil. All patients were genotyped for rs7903146 using Taqman technology. Results: Logistic regression analysis revealed that the risk of developing GDM in those with high adherence versus low adherence was significantly reduced only in carriers of the T-allele (CT + TT), with an adjusted odds ratio of 0.15 (95% CI:0.05–0.48). This effect was not observed in CC carriers. Interaction analysis yielded significant rs7903146-MedDiet interaction in GDM risk (p < 0.03) Conclusions: Women carrying the rs7903146 T-allele who highly adhere to a MedDiet early in pregnancy have lower risk of developing GDM than CC carriers. This reinforces the importance of identifying patients at risk of GDM who would be especially sensitive to nutritional interventions based on their genetic characteristics.http://www.sciencedirect.com/science/article/pii/S2589936820300499Gestational diabetes mellitusMediterranean dietNutritional interventionTCF7L2 polymorphismGene-diet interaction |
| spellingShingle | Ana Barabash Johanna D. Valerio Nuria Garcia de la Torre Inés Jimenez Laura del Valle Verónica Melero Carla Assaf-Balut Manuel Fuentes Elena Bordiu Alejandra Durán Miguel A. Herraiz Nuria Izquierdo María J. Torrejón Paz de Miguel Isabelle Runkle Miguel A. Rubio Alfonso L. Calle-Pascual TCF7L2 rs7903146 polymorphism modulates the association between adherence to a Mediterranean diet and the risk of gestational diabetes mellitus Metabolism Open Gestational diabetes mellitus Mediterranean diet Nutritional intervention TCF7L2 polymorphism Gene-diet interaction |
| title | TCF7L2 rs7903146 polymorphism modulates the association between adherence to a Mediterranean diet and the risk of gestational diabetes mellitus |
| title_full | TCF7L2 rs7903146 polymorphism modulates the association between adherence to a Mediterranean diet and the risk of gestational diabetes mellitus |
| title_fullStr | TCF7L2 rs7903146 polymorphism modulates the association between adherence to a Mediterranean diet and the risk of gestational diabetes mellitus |
| title_full_unstemmed | TCF7L2 rs7903146 polymorphism modulates the association between adherence to a Mediterranean diet and the risk of gestational diabetes mellitus |
| title_short | TCF7L2 rs7903146 polymorphism modulates the association between adherence to a Mediterranean diet and the risk of gestational diabetes mellitus |
| title_sort | tcf7l2 rs7903146 polymorphism modulates the association between adherence to a mediterranean diet and the risk of gestational diabetes mellitus |
| topic | Gestational diabetes mellitus Mediterranean diet Nutritional intervention TCF7L2 polymorphism Gene-diet interaction |
| url | http://www.sciencedirect.com/science/article/pii/S2589936820300499 |
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