Preliminary clinical assessment of dynamic carbon-11 methionine positron-emission tomography/computed tomography for the diagnosis of the pathologies in patients with musculoskeletal lesions: a prospective study
Abstract Background This study prospectively assessed the diagnostic capacity of dynamic carbon-11 methionine (C-11 MET) positron-emission tomography (PET)/computed tomography for the diagnosis of pathologies in patients with primary unknown musculoskeletal lesions (MSLs). In total, 13 patients with...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-08-01
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| Series: | European Journal of Hybrid Imaging |
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| Online Access: | http://link.springer.com/article/10.1186/s41824-020-00083-x |
| _version_ | 1818109840777543680 |
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| author | Takayoshi Shinya Yoichi Otomi Toshihiko Nishisho Bettina Beuthien-Baumann Michiko Kubo Hideki Otsuka Yoshimi Bando Hiroaki Yanagawa Koichi Sairyo Masafumi Harada |
| author_facet | Takayoshi Shinya Yoichi Otomi Toshihiko Nishisho Bettina Beuthien-Baumann Michiko Kubo Hideki Otsuka Yoshimi Bando Hiroaki Yanagawa Koichi Sairyo Masafumi Harada |
| author_sort | Takayoshi Shinya |
| collection | DOAJ |
| description | Abstract Background This study prospectively assessed the diagnostic capacity of dynamic carbon-11 methionine (C-11 MET) positron-emission tomography (PET)/computed tomography for the diagnosis of pathologies in patients with primary unknown musculoskeletal lesions (MSLs). In total, 13 patients with MSLs underwent dynamic scans (5–10 [phase 1], 10–15 [phase 2], 15–20 [phase 3], 20–25 [phase 4], 25–30 [phase 5], and 30–35 [phase 6] min post-injection of C-11 MET). We statistically compared the maximum standardised uptake values (SUVmax) and corresponding retention index for dynamic scans (RI-SUV) for five benign MSLs (BMSLs), five primary malignant musculoskeletal tumours (PMMSTs), four metastatic musculoskeletal tumours (MMSTs), and three malignant lymphoma (ML) cases and explored their diagnostic capacities using receiver operating characteristic (ROC) curve analyses. Results SUVmax gradually decreased or remained similar with minimal fluctuations in all BMSL cases and four of five PMMST cases. In contrast, SUVmax increased over time in one case of PMMST and in all cases of MMST and ML. Significant differences were observed in SUVmax for all time phases and RI-SUV between BMSLs and MMSLs, in SUVmax for all time phases between PMMSTs and BMSLs, in SUVmax for all time phases and RI-SUV between non-PMMST-malignant tumours and BMSL, and in RI-SUV between non-PMMST-malignant tumours and PMMST. In ROC analyses, the areas under the curve yielded the highest values at 1.00 for differentiating most intergroup comparisons. Conclusions Dynamic C-11 MET PET scans have the potential to be good predictors of discriminating MSLs in patients with primary unknown MSLs in clinical practice. |
| first_indexed | 2024-12-11T02:37:39Z |
| format | Article |
| id | doaj.art-0ac3762ce8394d548399c4bbeb62f23f |
| institution | Directory Open Access Journal |
| issn | 2510-3636 |
| language | English |
| last_indexed | 2024-12-11T02:37:39Z |
| publishDate | 2020-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | European Journal of Hybrid Imaging |
| spelling | doaj.art-0ac3762ce8394d548399c4bbeb62f23f2022-12-22T01:23:39ZengSpringerOpenEuropean Journal of Hybrid Imaging2510-36362020-08-014111310.1186/s41824-020-00083-xPreliminary clinical assessment of dynamic carbon-11 methionine positron-emission tomography/computed tomography for the diagnosis of the pathologies in patients with musculoskeletal lesions: a prospective studyTakayoshi Shinya0Yoichi Otomi1Toshihiko Nishisho2Bettina Beuthien-Baumann3Michiko Kubo4Hideki Otsuka5Yoshimi Bando6Hiroaki Yanagawa7Koichi Sairyo8Masafumi Harada9Department of Radiology, Tokushima University HospitalDepartment of Radiology, Tokushima University HospitalDepartment of Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate SchoolDivision of Radiology, German Cancer Research Centre (DKFZ)Department of Radiology, Tokushima University HospitalDepartment of Medical Imaging/Nuclear Medicine, Institute of Biomedical Sciences, Tokushima University Graduate SchoolDivision of Pathology, Tokushima University HospitalClinical Trial Center for Developmental Therapeutics, Tokushima University HospitalDepartment of Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate SchoolDepartment of Radiology, Tokushima University HospitalAbstract Background This study prospectively assessed the diagnostic capacity of dynamic carbon-11 methionine (C-11 MET) positron-emission tomography (PET)/computed tomography for the diagnosis of pathologies in patients with primary unknown musculoskeletal lesions (MSLs). In total, 13 patients with MSLs underwent dynamic scans (5–10 [phase 1], 10–15 [phase 2], 15–20 [phase 3], 20–25 [phase 4], 25–30 [phase 5], and 30–35 [phase 6] min post-injection of C-11 MET). We statistically compared the maximum standardised uptake values (SUVmax) and corresponding retention index for dynamic scans (RI-SUV) for five benign MSLs (BMSLs), five primary malignant musculoskeletal tumours (PMMSTs), four metastatic musculoskeletal tumours (MMSTs), and three malignant lymphoma (ML) cases and explored their diagnostic capacities using receiver operating characteristic (ROC) curve analyses. Results SUVmax gradually decreased or remained similar with minimal fluctuations in all BMSL cases and four of five PMMST cases. In contrast, SUVmax increased over time in one case of PMMST and in all cases of MMST and ML. Significant differences were observed in SUVmax for all time phases and RI-SUV between BMSLs and MMSLs, in SUVmax for all time phases between PMMSTs and BMSLs, in SUVmax for all time phases and RI-SUV between non-PMMST-malignant tumours and BMSL, and in RI-SUV between non-PMMST-malignant tumours and PMMST. In ROC analyses, the areas under the curve yielded the highest values at 1.00 for differentiating most intergroup comparisons. Conclusions Dynamic C-11 MET PET scans have the potential to be good predictors of discriminating MSLs in patients with primary unknown MSLs in clinical practice.http://link.springer.com/article/10.1186/s41824-020-00083-xMusculoskeletal lesionSarcomaMalignant lymphomaDiagnostic validityC-11 METDynamic PET/CT |
| spellingShingle | Takayoshi Shinya Yoichi Otomi Toshihiko Nishisho Bettina Beuthien-Baumann Michiko Kubo Hideki Otsuka Yoshimi Bando Hiroaki Yanagawa Koichi Sairyo Masafumi Harada Preliminary clinical assessment of dynamic carbon-11 methionine positron-emission tomography/computed tomography for the diagnosis of the pathologies in patients with musculoskeletal lesions: a prospective study European Journal of Hybrid Imaging Musculoskeletal lesion Sarcoma Malignant lymphoma Diagnostic validity C-11 MET Dynamic PET/CT |
| title | Preliminary clinical assessment of dynamic carbon-11 methionine positron-emission tomography/computed tomography for the diagnosis of the pathologies in patients with musculoskeletal lesions: a prospective study |
| title_full | Preliminary clinical assessment of dynamic carbon-11 methionine positron-emission tomography/computed tomography for the diagnosis of the pathologies in patients with musculoskeletal lesions: a prospective study |
| title_fullStr | Preliminary clinical assessment of dynamic carbon-11 methionine positron-emission tomography/computed tomography for the diagnosis of the pathologies in patients with musculoskeletal lesions: a prospective study |
| title_full_unstemmed | Preliminary clinical assessment of dynamic carbon-11 methionine positron-emission tomography/computed tomography for the diagnosis of the pathologies in patients with musculoskeletal lesions: a prospective study |
| title_short | Preliminary clinical assessment of dynamic carbon-11 methionine positron-emission tomography/computed tomography for the diagnosis of the pathologies in patients with musculoskeletal lesions: a prospective study |
| title_sort | preliminary clinical assessment of dynamic carbon 11 methionine positron emission tomography computed tomography for the diagnosis of the pathologies in patients with musculoskeletal lesions a prospective study |
| topic | Musculoskeletal lesion Sarcoma Malignant lymphoma Diagnostic validity C-11 MET Dynamic PET/CT |
| url | http://link.springer.com/article/10.1186/s41824-020-00083-x |
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