Towards dual function of autophagy in breast cancer: A potent regulator of tumor progression and therapy response
As a devastating disease, breast cancer has been responsible for decrease in life expectancy of females and its morbidity and mortality are high. Breast cancer is the most common tumor in females and its treatment has been based on employment of surgical resection, chemotherapy and radiotherapy. The...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223003347 |
| _version_ | 1797857661821124608 |
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| author | Mehrdad Hashemi Mahshid Deldar Abad Paskeh Sima Orouei Pegah Abbasi Ramin Khorrami Amir Dehghanpour Negin Esmaeili Azin Ghahremanzade Mohammad Arad Zandieh Maryam Peymani Shokooh Salimimoghadam Mohsen Rashidi Afshin Taheriazam Maliheh Entezari Kiavash Hushmandi |
| author_facet | Mehrdad Hashemi Mahshid Deldar Abad Paskeh Sima Orouei Pegah Abbasi Ramin Khorrami Amir Dehghanpour Negin Esmaeili Azin Ghahremanzade Mohammad Arad Zandieh Maryam Peymani Shokooh Salimimoghadam Mohsen Rashidi Afshin Taheriazam Maliheh Entezari Kiavash Hushmandi |
| author_sort | Mehrdad Hashemi |
| collection | DOAJ |
| description | As a devastating disease, breast cancer has been responsible for decrease in life expectancy of females and its morbidity and mortality are high. Breast cancer is the most common tumor in females and its treatment has been based on employment of surgical resection, chemotherapy and radiotherapy. The changes in biological behavior of breast tumor relies on genomic and epigenetic mutations and depletions as well as dysregulation of molecular mechanisms that autophagy is among them. Autophagy function can be oncogenic in increasing tumorigenesis, and when it has pro-death function, it causes reduction in viability of tumor cells. The carcinogenic function of autophagy in breast tumor is an impediment towards effective therapy of patients, as it can cause drug resistance and radio-resistance. The important hallmarks of breast tumor such as glucose metabolism, proliferation, apoptosis and metastasis can be regulated by autophagy. Oncogenic autophagy can inhibit apoptosis, while it promotes stemness of breast tumor. Moreover, autophagy demonstrates interaction with tumor microenvironment components such as macrophages and its level can be regulated by anti-tumor compounds in breast tumor therapy. The reasons of considering autophagy in breast cancer therapy is its pleiotropic function, dual role (pro-survival and pro-death) and crosstalk with important molecular mechanisms such as apoptosis. Moreover, current review provides a pre-clinical and clinical evaluation of autophagy in breast tumor. |
| first_indexed | 2024-04-09T21:00:23Z |
| format | Article |
| id | doaj.art-0ac6cb3323c947ecbbb136762db5a1f3 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-09T21:00:23Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-0ac6cb3323c947ecbbb136762db5a1f32023-03-29T09:24:11ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-05-01161114546Towards dual function of autophagy in breast cancer: A potent regulator of tumor progression and therapy responseMehrdad Hashemi0Mahshid Deldar Abad Paskeh1Sima Orouei2Pegah Abbasi3Ramin Khorrami4Amir Dehghanpour5Negin Esmaeili6Azin Ghahremanzade7Mohammad Arad Zandieh8Maryam Peymani9Shokooh Salimimoghadam10Mohsen Rashidi11Afshin Taheriazam12Maliheh Entezari13Kiavash Hushmandi14Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, IranFarhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, IranDepartment of Biology, Science and Research Branch, Islamic Azad University, Tehran, IranFarhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, IranDepartment of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, University of Tehran, Tehran, IranFarhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, IranFarhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, IranFarhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, IranDepartment of Food Hygiene and Quality Control, Division of Epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, IranDepartment of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, IranDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, IranDepartment Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari 4815733971, Iran; The Health of Plant and Livestock Products Research Center, Mazandaran University of Medical Sciences, Sari 4815733971, Iran; Corresponding author at: Department Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari 4815733971, Iran.Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Orthopedics, Faculty of medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Corresponding authors at: Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, IranFarhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Corresponding authors at: Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, IranDepartment of Food Hygiene and Quality Control, Division of Epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran; Corresponding author.As a devastating disease, breast cancer has been responsible for decrease in life expectancy of females and its morbidity and mortality are high. Breast cancer is the most common tumor in females and its treatment has been based on employment of surgical resection, chemotherapy and radiotherapy. The changes in biological behavior of breast tumor relies on genomic and epigenetic mutations and depletions as well as dysregulation of molecular mechanisms that autophagy is among them. Autophagy function can be oncogenic in increasing tumorigenesis, and when it has pro-death function, it causes reduction in viability of tumor cells. The carcinogenic function of autophagy in breast tumor is an impediment towards effective therapy of patients, as it can cause drug resistance and radio-resistance. The important hallmarks of breast tumor such as glucose metabolism, proliferation, apoptosis and metastasis can be regulated by autophagy. Oncogenic autophagy can inhibit apoptosis, while it promotes stemness of breast tumor. Moreover, autophagy demonstrates interaction with tumor microenvironment components such as macrophages and its level can be regulated by anti-tumor compounds in breast tumor therapy. The reasons of considering autophagy in breast cancer therapy is its pleiotropic function, dual role (pro-survival and pro-death) and crosstalk with important molecular mechanisms such as apoptosis. Moreover, current review provides a pre-clinical and clinical evaluation of autophagy in breast tumor.http://www.sciencedirect.com/science/article/pii/S0753332223003347Breast cancerAutophagyChemoresistanceProgrammed cell deathCancer therapy |
| spellingShingle | Mehrdad Hashemi Mahshid Deldar Abad Paskeh Sima Orouei Pegah Abbasi Ramin Khorrami Amir Dehghanpour Negin Esmaeili Azin Ghahremanzade Mohammad Arad Zandieh Maryam Peymani Shokooh Salimimoghadam Mohsen Rashidi Afshin Taheriazam Maliheh Entezari Kiavash Hushmandi Towards dual function of autophagy in breast cancer: A potent regulator of tumor progression and therapy response Biomedicine & Pharmacotherapy Breast cancer Autophagy Chemoresistance Programmed cell death Cancer therapy |
| title | Towards dual function of autophagy in breast cancer: A potent regulator of tumor progression and therapy response |
| title_full | Towards dual function of autophagy in breast cancer: A potent regulator of tumor progression and therapy response |
| title_fullStr | Towards dual function of autophagy in breast cancer: A potent regulator of tumor progression and therapy response |
| title_full_unstemmed | Towards dual function of autophagy in breast cancer: A potent regulator of tumor progression and therapy response |
| title_short | Towards dual function of autophagy in breast cancer: A potent regulator of tumor progression and therapy response |
| title_sort | towards dual function of autophagy in breast cancer a potent regulator of tumor progression and therapy response |
| topic | Breast cancer Autophagy Chemoresistance Programmed cell death Cancer therapy |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223003347 |
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