An internal thioester in a pathogen surface protein mediates covalent host binding

An internal thioester in a pathogen surface protein mediates covalent host binding

To cause disease and persist in a host, pathogenic and commensal microbes must adhere to tissues. Colonization and infection depend on specific molecular interactions at the host-microbe interface that involve microbial surface proteins, or adhesins. To date, adhesins are only known to bind to host...

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Bibliographic Details
Main Authors: Miriam Walden, John M Edwards, Aleksandra M Dziewulska, Rene Bergmann, Gerhard Saalbach, Su-Yin Kan, Ona K Miller, Miriam Weckener, Rosemary J Jackson, Sally L Shirran, Catherine H Botting, Gordon J Florence, Manfred Rohde, Mark J Banfield, Ulrich Schwarz-Linek
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-06-01
Series:eLife
Subjects:
Streptococcus pyogenes
Streptococcus pneumoniae
Clostridium perfringens
host-microbe interaction
fibrinogen
bacterial surface protein
Online Access:https://elifesciences.org/articles/06638

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