Vascular Regeneration in Ischemic Hindlimb by Adeno‐Associated Virus Expressing Conditionally Silenced Vascular Endothelial Growth Factor

Vascular Regeneration in Ischemic Hindlimb by Adeno‐Associated Virus Expressing Conditionally Silenced Vascular Endothelial Growth Factor

BackgroundCritical limb ischemia (CLI) is the extreme manifestation of peripheral artery disease, a major unmet clinical need for which lower limb amputation is the only option for many patients. After 2 decades in development, therapeutic angiogenesis has been tested clinically via intramuscular de...

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Bibliographic Details
Main Authors: Jeffrey Boden, Roberta Marques Lassance‐Soares, Huilan Wang, Yuntao Wei, Maria‐Grazia Spiga, Jennipher Adi, Hans Layman, Hong Yu, Roberto I. Vazquez‐Padron, Fotios Andreopoulos, Keith A. Webster
Format: Article
Language:English
Published: Wiley 2016-06-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
gene therapy
hypoxia
ischemia
peripheral vascular disease
revascularization
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.115.001815

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