Tyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammation
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is an important regulator of cell death pathways during embryogenesis and in infection/inflammation. Here authors show that tyrosine phosphorylation of RIPK1 by upstream kinases limits systemic inflammation and regulates haematopoietic h...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34080-4 |
| _version_ | 1828155903496421376 |
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| author | Hailin Tu Weihang Xiong Jie Zhang Xueqiang Zhao Xin Lin |
| author_facet | Hailin Tu Weihang Xiong Jie Zhang Xueqiang Zhao Xin Lin |
| author_sort | Hailin Tu |
| collection | DOAJ |
| description | Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is an important regulator of cell death pathways during embryogenesis and in infection/inflammation. Here authors show that tyrosine phosphorylation of RIPK1 by upstream kinases limits systemic inflammation and regulates haematopoietic homeostasis. |
| first_indexed | 2024-04-11T23:01:16Z |
| format | Article |
| id | doaj.art-0acf9270e0b144e599da71bad16734b5 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T23:01:16Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0acf9270e0b144e599da71bad16734b52022-12-22T03:58:07ZengNature PortfolioNature Communications2041-17232022-11-0113111410.1038/s41467-022-34080-4Tyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammationHailin Tu0Weihang Xiong1Jie Zhang2Xueqiang Zhao3Xin Lin4Institute for Immunology, School of Medicine, Tsinghua UniversityInstitute for Immunology, School of Medicine, Tsinghua UniversityInstitute for Immunology, School of Medicine, Tsinghua UniversityInstitute for Immunology, School of Medicine, Tsinghua UniversityInstitute for Immunology, School of Medicine, Tsinghua UniversityReceptor-interacting serine/threonine-protein kinase 1 (RIPK1) is an important regulator of cell death pathways during embryogenesis and in infection/inflammation. Here authors show that tyrosine phosphorylation of RIPK1 by upstream kinases limits systemic inflammation and regulates haematopoietic homeostasis.https://doi.org/10.1038/s41467-022-34080-4 |
| spellingShingle | Hailin Tu Weihang Xiong Jie Zhang Xueqiang Zhao Xin Lin Tyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammation Nature Communications |
| title | Tyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammation |
| title_full | Tyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammation |
| title_fullStr | Tyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammation |
| title_full_unstemmed | Tyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammation |
| title_short | Tyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammation |
| title_sort | tyrosine phosphorylation regulates ripk1 activity to limit cell death and inflammation |
| url | https://doi.org/10.1038/s41467-022-34080-4 |
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