The Presence of <i>Exophiala dermatitidis</i> in the Respiratory Tract of Cystic Fibrosis Patients Accelerates Lung Function Decline: A Retrospective Review of Lung Function
<i>Exophiala dermatitidis</i> is increasingly isolated from cystic fibrosis (CF) respiratory samples. The decision to treat is hampered by limited evidence demonstrating the clinical significance of isolating <i>E. dermatitidis</i>. The objective was to assess the impact of &...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/8/4/376 |
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| author | Jonathan Ayling-Smith Lorraine Speight Rishi Dhillon Matthijs Backx Philip Lewis White Kerenza Hood Jamie Duckers |
| author_facet | Jonathan Ayling-Smith Lorraine Speight Rishi Dhillon Matthijs Backx Philip Lewis White Kerenza Hood Jamie Duckers |
| author_sort | Jonathan Ayling-Smith |
| collection | DOAJ |
| description | <i>Exophiala dermatitidis</i> is increasingly isolated from cystic fibrosis (CF) respiratory samples. The decision to treat is hampered by limited evidence demonstrating the clinical significance of isolating <i>E. dermatitidis</i>. The objective was to assess the impact of <i>E. dermatitidis</i> isolation on the lung function of CF patients. The rate of lung function decline in the local CF population was calculated using historic lung function data. A control population who had never had <i>E. dermatitidis</i> cultured from the respiratory tract was compared with the <i>E. dermatitidis</i> group, calculating their rate of lung function decline before and after the first isolation of the organism. A total of 1840 lung function measurements were reviewed between the 31 <i>E. dermatitidis</i> group patients and 62 control patients. Their demographics were similar. The control group declined at a rate of −0.824 FEV1%/year. The rate of decline in the <i>E. dermatitidis</i> group prior to infection was −0.337 FEV1%/year (<i>p</i> = 0.2). However, post infection with <i>E. dermatitidis</i>, there was a significant increase in the rate of decline in lung function (−1.824 FEV1%/year, <i>p</i> < 0.01). The results suggest <i>E. dermatitidis</i> has a temporal relationship with accelerated rate of lung function decline. It is not clear if this is a cause or effect, but this accelerated rate of decline indicates a need for further investigation. |
| first_indexed | 2024-03-09T10:32:41Z |
| format | Article |
| id | doaj.art-0ad035493e0e4a2f8cac433e149d8024 |
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| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-09T10:32:41Z |
| publishDate | 2022-04-01 |
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| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-0ad035493e0e4a2f8cac433e149d80242023-12-01T21:08:22ZengMDPI AGJournal of Fungi2309-608X2022-04-018437610.3390/jof8040376The Presence of <i>Exophiala dermatitidis</i> in the Respiratory Tract of Cystic Fibrosis Patients Accelerates Lung Function Decline: A Retrospective Review of Lung FunctionJonathan Ayling-Smith0Lorraine Speight1Rishi Dhillon2Matthijs Backx3Philip Lewis White4Kerenza Hood5Jamie Duckers6University Hospital of Wales, Cardiff and Vale University Health Board, Cardiff CF14 4XW, UKAll Wales Adult Cystic Fibrosis Centre, University Hospital Llandough, Penarth CF64 2XX, UKPublic Health Wales, Cardiff CF10 4BZ, UKPublic Health Wales, Cardiff CF10 4BZ, UKPublic Health Wales, Cardiff CF10 4BZ, UKCollege of Biomedical and Life Sciences, Cardiff University, Cardiff CF10 3AT, UKAll Wales Adult Cystic Fibrosis Centre, University Hospital Llandough, Penarth CF64 2XX, UK<i>Exophiala dermatitidis</i> is increasingly isolated from cystic fibrosis (CF) respiratory samples. The decision to treat is hampered by limited evidence demonstrating the clinical significance of isolating <i>E. dermatitidis</i>. The objective was to assess the impact of <i>E. dermatitidis</i> isolation on the lung function of CF patients. The rate of lung function decline in the local CF population was calculated using historic lung function data. A control population who had never had <i>E. dermatitidis</i> cultured from the respiratory tract was compared with the <i>E. dermatitidis</i> group, calculating their rate of lung function decline before and after the first isolation of the organism. A total of 1840 lung function measurements were reviewed between the 31 <i>E. dermatitidis</i> group patients and 62 control patients. Their demographics were similar. The control group declined at a rate of −0.824 FEV1%/year. The rate of decline in the <i>E. dermatitidis</i> group prior to infection was −0.337 FEV1%/year (<i>p</i> = 0.2). However, post infection with <i>E. dermatitidis</i>, there was a significant increase in the rate of decline in lung function (−1.824 FEV1%/year, <i>p</i> < 0.01). The results suggest <i>E. dermatitidis</i> has a temporal relationship with accelerated rate of lung function decline. It is not clear if this is a cause or effect, but this accelerated rate of decline indicates a need for further investigation.https://www.mdpi.com/2309-608X/8/4/376cystic fibrosis<i>Exophiala dermatitidis</i>lung function |
| spellingShingle | Jonathan Ayling-Smith Lorraine Speight Rishi Dhillon Matthijs Backx Philip Lewis White Kerenza Hood Jamie Duckers The Presence of <i>Exophiala dermatitidis</i> in the Respiratory Tract of Cystic Fibrosis Patients Accelerates Lung Function Decline: A Retrospective Review of Lung Function Journal of Fungi cystic fibrosis <i>Exophiala dermatitidis</i> lung function |
| title | The Presence of <i>Exophiala dermatitidis</i> in the Respiratory Tract of Cystic Fibrosis Patients Accelerates Lung Function Decline: A Retrospective Review of Lung Function |
| title_full | The Presence of <i>Exophiala dermatitidis</i> in the Respiratory Tract of Cystic Fibrosis Patients Accelerates Lung Function Decline: A Retrospective Review of Lung Function |
| title_fullStr | The Presence of <i>Exophiala dermatitidis</i> in the Respiratory Tract of Cystic Fibrosis Patients Accelerates Lung Function Decline: A Retrospective Review of Lung Function |
| title_full_unstemmed | The Presence of <i>Exophiala dermatitidis</i> in the Respiratory Tract of Cystic Fibrosis Patients Accelerates Lung Function Decline: A Retrospective Review of Lung Function |
| title_short | The Presence of <i>Exophiala dermatitidis</i> in the Respiratory Tract of Cystic Fibrosis Patients Accelerates Lung Function Decline: A Retrospective Review of Lung Function |
| title_sort | presence of i exophiala dermatitidis i in the respiratory tract of cystic fibrosis patients accelerates lung function decline a retrospective review of lung function |
| topic | cystic fibrosis <i>Exophiala dermatitidis</i> lung function |
| url | https://www.mdpi.com/2309-608X/8/4/376 |
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