Increased SIRT3 combined with PARP inhibition rescues motor function of SBMA mice

Increased SIRT3 combined with PARP inhibition rescues motor function of SBMA mice

Summary: Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease with substantial mitochondrial and metabolic dysfunctions. SBMA is caused by polyglutamine (polyQ) expansion in the androgen receptor (AR). Activating or increasing the NAD+-dependent deacetylase, SIRT3, reduced oxidative...

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Bibliographic Details
Main Authors: David R. Garcia Castro, Joseph R. Mazuk, Erin M. Heine, Daniel Simpson, R. Seth Pinches, Caroline Lozzi, Kathryn Hoffman, Phillip Morrin, Dylan Mathis, Maria V. Lebedev, Elyse Nissley, Kang Hoo Han, Tyler Farmer, Diane E. Merry, Qiang Tong, Maria Pennuto, Heather L. Montie
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:iScience
Subjects:
Biological sciences
Biochemistry
Molecular biology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223014529

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http://www.sciencedirect.com/science/article/pii/S2589004223014529

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