Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis
Invasive aspergillosis (IA) is a life-threatening infection due to Aspergillus fumigatus and other Aspergillus spp. Drugs targeting the fungal cell membrane (triazoles, amphotericin B) or cell wall (echinocandins) are currently the sole therapeutic options against IA. Their limited efficacy and the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-02-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00096/full |
| _version_ | 1819110986153459712 |
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| author | Frederic eLamoth Praveen Rao Juvvadi William J Steinbach |
| author_facet | Frederic eLamoth Praveen Rao Juvvadi William J Steinbach |
| author_sort | Frederic eLamoth |
| collection | DOAJ |
| description | Invasive aspergillosis (IA) is a life-threatening infection due to Aspergillus fumigatus and other Aspergillus spp. Drugs targeting the fungal cell membrane (triazoles, amphotericin B) or cell wall (echinocandins) are currently the sole therapeutic options against IA. Their limited efficacy and the emergence of resistance warrant the identification of new antifungal targets. Histone deacetylases (HDACs) are enzymes responsible of the deacetylation of lysine residues of core histones, thus controlling chromatin remodeling and transcriptional activation. HDACs also control the acetylation and activation status of multiple non-histone proteins, including the heat shock protein 90 (Hsp90), an essential molecular chaperone for fungal virulence and antifungal resistance. This review provides an overview of the different HDACs in Aspergillus spp. as well as their respective contribution to total HDAC activity, fungal growth, stress responses, and virulence. The potential of HDAC inhibitors, currently under development for cancer therapy, as novel alternative antifungal agents against IA is discussed. |
| first_indexed | 2024-12-22T03:50:26Z |
| format | Article |
| id | doaj.art-0ad2efe7adad4bdc84777970b856cf72 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-22T03:50:26Z |
| publishDate | 2015-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-0ad2efe7adad4bdc84777970b856cf722022-12-21T18:40:00ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2015-02-01610.3389/fmicb.2015.00096130381Histone deacetylase inhibition as an alternative strategy against invasive aspergillosisFrederic eLamoth0Praveen Rao Juvvadi1William J Steinbach2Duke UniversityDuke UniversityDuke UniversityInvasive aspergillosis (IA) is a life-threatening infection due to Aspergillus fumigatus and other Aspergillus spp. Drugs targeting the fungal cell membrane (triazoles, amphotericin B) or cell wall (echinocandins) are currently the sole therapeutic options against IA. Their limited efficacy and the emergence of resistance warrant the identification of new antifungal targets. Histone deacetylases (HDACs) are enzymes responsible of the deacetylation of lysine residues of core histones, thus controlling chromatin remodeling and transcriptional activation. HDACs also control the acetylation and activation status of multiple non-histone proteins, including the heat shock protein 90 (Hsp90), an essential molecular chaperone for fungal virulence and antifungal resistance. This review provides an overview of the different HDACs in Aspergillus spp. as well as their respective contribution to total HDAC activity, fungal growth, stress responses, and virulence. The potential of HDAC inhibitors, currently under development for cancer therapy, as novel alternative antifungal agents against IA is discussed.http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00096/fullAspergillus fumigatusantifungal resistanceTrichostatin Aantifungal therapyHeat shock protein 90 (hsp90)Lysine deacetylases |
| spellingShingle | Frederic eLamoth Praveen Rao Juvvadi William J Steinbach Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis Frontiers in Microbiology Aspergillus fumigatus antifungal resistance Trichostatin A antifungal therapy Heat shock protein 90 (hsp90) Lysine deacetylases |
| title | Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis |
| title_full | Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis |
| title_fullStr | Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis |
| title_full_unstemmed | Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis |
| title_short | Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis |
| title_sort | histone deacetylase inhibition as an alternative strategy against invasive aspergillosis |
| topic | Aspergillus fumigatus antifungal resistance Trichostatin A antifungal therapy Heat shock protein 90 (hsp90) Lysine deacetylases |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00096/full |
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