Body Fat Distribution, Overweight, and Cardiac Structures in School‐Age Children: A Population‐Based Cardiac Magnetic Resonance Imaging Study
Background Adiposity is associated with larger left ventricular mass in children and adults. The role of body fat distribution in these associations is not clear. We examined the associations of body fat distribution and overweight with cardiac measures obtained by cardiac magnetic resonance imaging...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-07-01
|
| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.119.014933 |
| _version_ | 1819175062883794944 |
|---|---|
| author | Liza Toemen Susana Santos Arno A. Roest Gavro Jelic Aad van der Lugt Janine F. Felix Willem A. Helbing Romy Gaillard Vincent W. V. Jaddoe |
| author_facet | Liza Toemen Susana Santos Arno A. Roest Gavro Jelic Aad van der Lugt Janine F. Felix Willem A. Helbing Romy Gaillard Vincent W. V. Jaddoe |
| author_sort | Liza Toemen |
| collection | DOAJ |
| description | Background Adiposity is associated with larger left ventricular mass in children and adults. The role of body fat distribution in these associations is not clear. We examined the associations of body fat distribution and overweight with cardiac measures obtained by cardiac magnetic resonance imaging in school‐age children. Methods and Results In a population‐based cohort study including 2836 children, 10 years of age, we used anthropometric measures, dual‐energy X‐ray absorptiometry, and magnetic resonance imaging to collect information on body mass index, lean mass index, fat mass index, and abdominal visceral adipose tissue index. Indexes were standardized by height. Cardiac measures included right and left ventricular end‐diastolic volume, left ventricular mass, and mass‐to‐volume ratio as a marker for concentricity. All body fat measures were positively associated with right and left ventricular end‐diastolic volumes and left ventricular mass, with the strongest associations for lean mass index (all P<0.05). Obese children had a 1.12 standard deviation score (95% CI, 0.94–1.30) larger left ventricular mass and a 0.35 standard deviation score (95% CI, 0.14–0.57) higher left ventricular mass‐to‐volume ratio than normal weight children. Conditional on body mass index, higher lean mass index was associated with higher right and left ventricular end‐diastolic volume and left ventricular mass, whereas higher fat mass measures were inversely associated with these cardiac measures (all P<0.05). Conclusions Higher childhood body mass index is associated with a larger right and left ventricular size. This association is influenced by higher lean mass. In childhood, lean mass may be a stronger determinant of heart growth than fat mass. Fat mass may influence cardiac structures at older ages. |
| first_indexed | 2024-12-22T20:48:54Z |
| format | Article |
| id | doaj.art-0ad3473973b14a8e9df6dcf266b5fe1a |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-22T20:48:54Z |
| publishDate | 2020-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-0ad3473973b14a8e9df6dcf266b5fe1a2022-12-21T18:13:08ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802020-07-0191310.1161/JAHA.119.014933Body Fat Distribution, Overweight, and Cardiac Structures in School‐Age Children: A Population‐Based Cardiac Magnetic Resonance Imaging StudyLiza Toemen0Susana Santos1Arno A. Roest2Gavro Jelic3Aad van der Lugt4Janine F. Felix5Willem A. Helbing6Romy Gaillard7Vincent W. V. Jaddoe8Generation R Study Group Erasmus MC, University Medical Center Rotterdam The NetherlandsGeneration R Study Group Erasmus MC, University Medical Center Rotterdam The NetherlandsDepartment of Pediatrics Leiden University Medical Center Leiden The NetherlandsGeneration R Study Group Erasmus MC, University Medical Center Rotterdam The NetherlandsRadiology Erasmus MC, University Medical Center Rotterdam The NetherlandsGeneration R Study Group Erasmus MC, University Medical Center Rotterdam The NetherlandsPediatrics Erasmus MC, University Medical Center Rotterdam The NetherlandsGeneration R Study Group Erasmus MC, University Medical Center Rotterdam The NetherlandsGeneration R Study Group Erasmus MC, University Medical Center Rotterdam The NetherlandsBackground Adiposity is associated with larger left ventricular mass in children and adults. The role of body fat distribution in these associations is not clear. We examined the associations of body fat distribution and overweight with cardiac measures obtained by cardiac magnetic resonance imaging in school‐age children. Methods and Results In a population‐based cohort study including 2836 children, 10 years of age, we used anthropometric measures, dual‐energy X‐ray absorptiometry, and magnetic resonance imaging to collect information on body mass index, lean mass index, fat mass index, and abdominal visceral adipose tissue index. Indexes were standardized by height. Cardiac measures included right and left ventricular end‐diastolic volume, left ventricular mass, and mass‐to‐volume ratio as a marker for concentricity. All body fat measures were positively associated with right and left ventricular end‐diastolic volumes and left ventricular mass, with the strongest associations for lean mass index (all P<0.05). Obese children had a 1.12 standard deviation score (95% CI, 0.94–1.30) larger left ventricular mass and a 0.35 standard deviation score (95% CI, 0.14–0.57) higher left ventricular mass‐to‐volume ratio than normal weight children. Conditional on body mass index, higher lean mass index was associated with higher right and left ventricular end‐diastolic volume and left ventricular mass, whereas higher fat mass measures were inversely associated with these cardiac measures (all P<0.05). Conclusions Higher childhood body mass index is associated with a larger right and left ventricular size. This association is influenced by higher lean mass. In childhood, lean mass may be a stronger determinant of heart growth than fat mass. Fat mass may influence cardiac structures at older ages.https://www.ahajournals.org/doi/10.1161/JAHA.119.014933cardiac MRIepidemiologyobesitypediatrics |
| spellingShingle | Liza Toemen Susana Santos Arno A. Roest Gavro Jelic Aad van der Lugt Janine F. Felix Willem A. Helbing Romy Gaillard Vincent W. V. Jaddoe Body Fat Distribution, Overweight, and Cardiac Structures in School‐Age Children: A Population‐Based Cardiac Magnetic Resonance Imaging Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease cardiac MRI epidemiology obesity pediatrics |
| title | Body Fat Distribution, Overweight, and Cardiac Structures in School‐Age Children: A Population‐Based Cardiac Magnetic Resonance Imaging Study |
| title_full | Body Fat Distribution, Overweight, and Cardiac Structures in School‐Age Children: A Population‐Based Cardiac Magnetic Resonance Imaging Study |
| title_fullStr | Body Fat Distribution, Overweight, and Cardiac Structures in School‐Age Children: A Population‐Based Cardiac Magnetic Resonance Imaging Study |
| title_full_unstemmed | Body Fat Distribution, Overweight, and Cardiac Structures in School‐Age Children: A Population‐Based Cardiac Magnetic Resonance Imaging Study |
| title_short | Body Fat Distribution, Overweight, and Cardiac Structures in School‐Age Children: A Population‐Based Cardiac Magnetic Resonance Imaging Study |
| title_sort | body fat distribution overweight and cardiac structures in school age children a population based cardiac magnetic resonance imaging study |
| topic | cardiac MRI epidemiology obesity pediatrics |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.119.014933 |
| work_keys_str_mv | AT lizatoemen bodyfatdistributionoverweightandcardiacstructuresinschoolagechildrenapopulationbasedcardiacmagneticresonanceimagingstudy AT susanasantos bodyfatdistributionoverweightandcardiacstructuresinschoolagechildrenapopulationbasedcardiacmagneticresonanceimagingstudy AT arnoaroest bodyfatdistributionoverweightandcardiacstructuresinschoolagechildrenapopulationbasedcardiacmagneticresonanceimagingstudy AT gavrojelic bodyfatdistributionoverweightandcardiacstructuresinschoolagechildrenapopulationbasedcardiacmagneticresonanceimagingstudy AT aadvanderlugt bodyfatdistributionoverweightandcardiacstructuresinschoolagechildrenapopulationbasedcardiacmagneticresonanceimagingstudy AT janineffelix bodyfatdistributionoverweightandcardiacstructuresinschoolagechildrenapopulationbasedcardiacmagneticresonanceimagingstudy AT willemahelbing bodyfatdistributionoverweightandcardiacstructuresinschoolagechildrenapopulationbasedcardiacmagneticresonanceimagingstudy AT romygaillard bodyfatdistributionoverweightandcardiacstructuresinschoolagechildrenapopulationbasedcardiacmagneticresonanceimagingstudy AT vincentwvjaddoe bodyfatdistributionoverweightandcardiacstructuresinschoolagechildrenapopulationbasedcardiacmagneticresonanceimagingstudy |