Immunomodulatory effect and safety of TNF-α RNAi mediated by oral yeast microcapsules in rheumatoid arthritis therapy

Immunomodulatory effect and safety of TNF-α RNAi mediated by oral yeast microcapsules in rheumatoid arthritis therapy

Rheumatoid arthritis (RA) is a chronic autoimmune disease that requires long-term treatment and monitoring. Inhibition of inflammatory gene expression by gene therapy is a significant breakthrough in RA treatment, but the lack of a safe and effective gene delivery system hinders its application. Sin...

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Bibliographic Details
Main Authors: Nan Hu, Li Zhu, Li Zhang, Jing Wang, Yanhua Wang, Jing Luo, Lan He, Zhiming Hao, Long Zhang
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Materials Today Bio
Subjects:
Rheumatoid arthritis
Oral administration
Gene therapy
Immunomodulation
Online Access:http://www.sciencedirect.com/science/article/pii/S259000642200182X

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