Could tau-PET imaging contribute to a better understanding of the different patterns of clinical progression in Alzheimer’s disease? A 2-year longitudinal study
Abstract Background Monitoring the progression of Tau pathology makes it possible to study the clinical diversity of Alzheimer’s disease. In this 2-year longitudinal PET study, we aimed to determine the progression of [18F]-flortaucipir binding and of cortical atrophy, and their relationships with c...
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | Alzheimer’s Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13195-023-01237-2 |
| _version_ | 1797832134671466496 |
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| author | Julien Lagarde Pauline Olivieri Matteo Tonietto Sébastian Rodrigo Philippe Gervais Fabien Caillé Martin Moussion Michel Bottlaender Marie Sarazin |
| author_facet | Julien Lagarde Pauline Olivieri Matteo Tonietto Sébastian Rodrigo Philippe Gervais Fabien Caillé Martin Moussion Michel Bottlaender Marie Sarazin |
| author_sort | Julien Lagarde |
| collection | DOAJ |
| description | Abstract Background Monitoring the progression of Tau pathology makes it possible to study the clinical diversity of Alzheimer’s disease. In this 2-year longitudinal PET study, we aimed to determine the progression of [18F]-flortaucipir binding and of cortical atrophy, and their relationships with cognitive decline. Methods Twenty-seven AD patients at the mild cognitive impairment/mild dementia stages and twelve amyloid-negative controls underwent a neuropsychological assessment, 3 T brain MRI, and [18F]-flortaucipir PET imaging (Tau1) and were monitored annually over 2 years with a second brain MRI and tau-PET imaging after 2 years (Tau2). We analyzed the progression of tau standardized uptake value ratio (SUVr) and grey matter atrophy both at the regional and voxelwise levels. We used mixed effects models to explore the relations between the progression of SUVr values, cortical atrophy, and cognitive decline. Results We found an average longitudinal increase in tau SUVr values, except for the lateral temporoparietal cortex where the average SUVr values decreased. Individual analyses revealed distinct profiles of SUVr progression according to temporoparietal Tau1 uptake: high-Tau1 patients demonstrated an increase in SUVr values over time in the frontal lobe, but a decrease in the temporoparietal cortex and a rapid clinical decline, while low-Tau1 patients displayed an increase in SUVr values in all cortical regions and a slower clinical decline. Cognitive decline was strongly associated with the progression of regional cortical atrophy, but only weakly associated with SUVr progression. Conclusions Despite a relatively small sample size, our results suggest that tau-PET imaging could identify patients with a potentially “more aggressive” clinical course characterized by high temporoparietal Tau1 SUVr values and a rapid clinical progression. In these patients, the paradoxical decrease in temporoparietal SUVr values over time could be due to the rapid transition to ghost tangles, for which the affinity of the radiotracer is lower. They could particularly benefit from future therapeutic trials, the neuroimaging outcome measures of which deserve to be discussed. |
| first_indexed | 2024-04-09T14:03:59Z |
| format | Article |
| id | doaj.art-0ad53e566d6a402ab083f0d09cdcccb5 |
| institution | Directory Open Access Journal |
| issn | 1758-9193 |
| language | English |
| last_indexed | 2024-04-09T14:03:59Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Alzheimer’s Research & Therapy |
| spelling | doaj.art-0ad53e566d6a402ab083f0d09cdcccb52023-05-07T11:07:55ZengBMCAlzheimer’s Research & Therapy1758-91932023-05-0115111210.1186/s13195-023-01237-2Could tau-PET imaging contribute to a better understanding of the different patterns of clinical progression in Alzheimer’s disease? A 2-year longitudinal studyJulien Lagarde0Pauline Olivieri1Matteo Tonietto2Sébastian Rodrigo3Philippe Gervais4Fabien Caillé5Martin Moussion6Michel Bottlaender7Marie Sarazin8Department of Neurology of Memory and Language, GHU Paris Psychiatrie & Neurosciences, Hôpital Sainte AnneDepartment of Neurology of Memory and Language, GHU Paris Psychiatrie & Neurosciences, Hôpital Sainte AnneUniversité Paris-Saclay, BioMaps, Service Hospitalier Frédéric Joliot CEA, CNRSUniversité Paris-Saclay, BioMaps, Service Hospitalier Frédéric Joliot CEA, CNRSUniversité Paris-Saclay, BioMaps, Service Hospitalier Frédéric Joliot CEA, CNRSUniversité Paris-Saclay, BioMaps, Service Hospitalier Frédéric Joliot CEA, CNRSDepartment of Neurology of Memory and Language, GHU Paris Psychiatrie & Neurosciences, Hôpital Sainte AnneUniversité Paris-Saclay, BioMaps, Service Hospitalier Frédéric Joliot CEA, CNRSDepartment of Neurology of Memory and Language, GHU Paris Psychiatrie & Neurosciences, Hôpital Sainte AnneAbstract Background Monitoring the progression of Tau pathology makes it possible to study the clinical diversity of Alzheimer’s disease. In this 2-year longitudinal PET study, we aimed to determine the progression of [18F]-flortaucipir binding and of cortical atrophy, and their relationships with cognitive decline. Methods Twenty-seven AD patients at the mild cognitive impairment/mild dementia stages and twelve amyloid-negative controls underwent a neuropsychological assessment, 3 T brain MRI, and [18F]-flortaucipir PET imaging (Tau1) and were monitored annually over 2 years with a second brain MRI and tau-PET imaging after 2 years (Tau2). We analyzed the progression of tau standardized uptake value ratio (SUVr) and grey matter atrophy both at the regional and voxelwise levels. We used mixed effects models to explore the relations between the progression of SUVr values, cortical atrophy, and cognitive decline. Results We found an average longitudinal increase in tau SUVr values, except for the lateral temporoparietal cortex where the average SUVr values decreased. Individual analyses revealed distinct profiles of SUVr progression according to temporoparietal Tau1 uptake: high-Tau1 patients demonstrated an increase in SUVr values over time in the frontal lobe, but a decrease in the temporoparietal cortex and a rapid clinical decline, while low-Tau1 patients displayed an increase in SUVr values in all cortical regions and a slower clinical decline. Cognitive decline was strongly associated with the progression of regional cortical atrophy, but only weakly associated with SUVr progression. Conclusions Despite a relatively small sample size, our results suggest that tau-PET imaging could identify patients with a potentially “more aggressive” clinical course characterized by high temporoparietal Tau1 SUVr values and a rapid clinical progression. In these patients, the paradoxical decrease in temporoparietal SUVr values over time could be due to the rapid transition to ghost tangles, for which the affinity of the radiotracer is lower. They could particularly benefit from future therapeutic trials, the neuroimaging outcome measures of which deserve to be discussed.https://doi.org/10.1186/s13195-023-01237-2Alzheimer’s diseasePETMRITauopathy |
| spellingShingle | Julien Lagarde Pauline Olivieri Matteo Tonietto Sébastian Rodrigo Philippe Gervais Fabien Caillé Martin Moussion Michel Bottlaender Marie Sarazin Could tau-PET imaging contribute to a better understanding of the different patterns of clinical progression in Alzheimer’s disease? A 2-year longitudinal study Alzheimer’s Research & Therapy Alzheimer’s disease PET MRI Tauopathy |
| title | Could tau-PET imaging contribute to a better understanding of the different patterns of clinical progression in Alzheimer’s disease? A 2-year longitudinal study |
| title_full | Could tau-PET imaging contribute to a better understanding of the different patterns of clinical progression in Alzheimer’s disease? A 2-year longitudinal study |
| title_fullStr | Could tau-PET imaging contribute to a better understanding of the different patterns of clinical progression in Alzheimer’s disease? A 2-year longitudinal study |
| title_full_unstemmed | Could tau-PET imaging contribute to a better understanding of the different patterns of clinical progression in Alzheimer’s disease? A 2-year longitudinal study |
| title_short | Could tau-PET imaging contribute to a better understanding of the different patterns of clinical progression in Alzheimer’s disease? A 2-year longitudinal study |
| title_sort | could tau pet imaging contribute to a better understanding of the different patterns of clinical progression in alzheimer s disease a 2 year longitudinal study |
| topic | Alzheimer’s disease PET MRI Tauopathy |
| url | https://doi.org/10.1186/s13195-023-01237-2 |
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