Thyrotropinoma and multinodular goiter: A diagnostic challenge for hyperthyroidism

Thyroid disorders are frequently encountered. The diagnosis is straightforward unless clinical or laboratory findings are inconclusive and/or perplexing. Hyperthyroidism due to a thyrotropin-secreting pituitary adenoma rarely occurs and symptoms due to thyroid hormone excess are subtle. The presenta...

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Main Authors: Duygu Yazgan Aksoy, Arzu Gedik, Nese Cinar, Figen Soylemezoglu, Mustafa Berker, Omer Alper Gurlek
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2013-01-01
Series:Journal of Research in Medical Sciences
Subjects:
Online Access:http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2013;volume=18;issue=11;spage=1008;epage=1010;aulast=Aksoy
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author Duygu Yazgan Aksoy
Arzu Gedik
Nese Cinar
Figen Soylemezoglu
Mustafa Berker
Omer Alper Gurlek
author_facet Duygu Yazgan Aksoy
Arzu Gedik
Nese Cinar
Figen Soylemezoglu
Mustafa Berker
Omer Alper Gurlek
author_sort Duygu Yazgan Aksoy
collection DOAJ
description Thyroid disorders are frequently encountered. The diagnosis is straightforward unless clinical or laboratory findings are inconclusive and/or perplexing. Hyperthyroidism due to a thyrotropin-secreting pituitary adenoma rarely occurs and symptoms due to thyroid hormone excess are subtle. The presentation of the disease becomes unusual when co-secretion of other hormones with thyrotropin or concomitant thyroid parenchymal pathology exist. We present the case of a 63-year-old female patient with thyrotropinoma co-secreting growth hormone and multinodular goiter. She developed hyperthyroidism first due to thyrotropinoma and later due to a toxic nodule. Herein, we discuss the diagnostic and therapeutic challenges of hyperthyroidism with atypical presentation.
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spelling doaj.art-0ad5e9d89a5044b683b8db1837cbb1dc2022-12-22T03:55:51ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362013-01-01181110081010Thyrotropinoma and multinodular goiter: A diagnostic challenge for hyperthyroidismDuygu Yazgan AksoyArzu GedikNese CinarFigen SoylemezogluMustafa BerkerOmer Alper GurlekThyroid disorders are frequently encountered. The diagnosis is straightforward unless clinical or laboratory findings are inconclusive and/or perplexing. Hyperthyroidism due to a thyrotropin-secreting pituitary adenoma rarely occurs and symptoms due to thyroid hormone excess are subtle. The presentation of the disease becomes unusual when co-secretion of other hormones with thyrotropin or concomitant thyroid parenchymal pathology exist. We present the case of a 63-year-old female patient with thyrotropinoma co-secreting growth hormone and multinodular goiter. She developed hyperthyroidism first due to thyrotropinoma and later due to a toxic nodule. Herein, we discuss the diagnostic and therapeutic challenges of hyperthyroidism with atypical presentation.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2013;volume=18;issue=11;spage=1008;epage=1010;aulast=AksoyCentral hyperthyroidismthyrotropinoma (TSHoma)TSH-secreting adenomatoxic goitertoxic nodular goiter
spellingShingle Duygu Yazgan Aksoy
Arzu Gedik
Nese Cinar
Figen Soylemezoglu
Mustafa Berker
Omer Alper Gurlek
Thyrotropinoma and multinodular goiter: A diagnostic challenge for hyperthyroidism
Journal of Research in Medical Sciences
Central hyperthyroidism
thyrotropinoma (TSHoma)
TSH-secreting adenoma
toxic goiter
toxic nodular goiter
title Thyrotropinoma and multinodular goiter: A diagnostic challenge for hyperthyroidism
title_full Thyrotropinoma and multinodular goiter: A diagnostic challenge for hyperthyroidism
title_fullStr Thyrotropinoma and multinodular goiter: A diagnostic challenge for hyperthyroidism
title_full_unstemmed Thyrotropinoma and multinodular goiter: A diagnostic challenge for hyperthyroidism
title_short Thyrotropinoma and multinodular goiter: A diagnostic challenge for hyperthyroidism
title_sort thyrotropinoma and multinodular goiter a diagnostic challenge for hyperthyroidism
topic Central hyperthyroidism
thyrotropinoma (TSHoma)
TSH-secreting adenoma
toxic goiter
toxic nodular goiter
url http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2013;volume=18;issue=11;spage=1008;epage=1010;aulast=Aksoy
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