Influence of marital status on overall survival in adult patients with chordoma: a SEER-based study
Abstract Background As a rare primary bone tumor, no studies have reported the relationship between prognosis and marital status in patients with chordoma. Methods We classified patients with chordoma identified from the Surveillance, Epidemiology, and End Results (SEER) database from 1975 to 2016 i...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-07-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13018-020-01803-6 |
| _version_ | 1798035357241966592 |
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| author | Chao Tang Ruiliang Wang Qingguo Lu Shantao Wang Gen Jia Pengfei Cao Xinfa Nie Hailong Zhang |
| author_facet | Chao Tang Ruiliang Wang Qingguo Lu Shantao Wang Gen Jia Pengfei Cao Xinfa Nie Hailong Zhang |
| author_sort | Chao Tang |
| collection | DOAJ |
| description | Abstract Background As a rare primary bone tumor, no studies have reported the relationship between prognosis and marital status in patients with chordoma. Methods We classified patients with chordoma identified from the Surveillance, Epidemiology, and End Results (SEER) database from 1975 to 2016 into four groups: married, divorced/separated, widowed, and single groups. Kaplan-Meier curves with log-rank test and Cox regression were used to analyze the effect of marital status on overall survival (OS). Results A total of 1080 patients were included in the study: 700 (64.8%) were married, 88 (8.1%) were divorced/separated, 78 (7.2%) were widowed, and 214 (19.8%) were single. Among the 4 groups, the 5-year OS (45.2%), 10-year OS (12.5%), and median OS (56.0 months) were the lowest in the widowed group. After including age, sex, primary site, marital status, disease stage, tumor size, histological type, and treatment pattern, multivariate analysis showed that marital status was still an independent risk factor for patients with chordoma, and widowed patients had the lowest OS (hazard ratio [HR] 1.71; 95% confidence interval [CI] 1.25–2.33, p < 0.001) compared with married patients. Similar results were observed after stratifying the primary site and disease stage. Conclusion Marital status was an independent prognostic indicator for adult patients with chordoma, and marital status was conducive to patient survival. Compared with married patients, widowed patients have a higher risk of death. |
| first_indexed | 2024-04-11T20:57:05Z |
| format | Article |
| id | doaj.art-0ad6239d2a584537bdb3dc5fc2b891ac |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-11T20:57:05Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-0ad6239d2a584537bdb3dc5fc2b891ac2022-12-22T04:03:38ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2020-07-0115111310.1186/s13018-020-01803-6Influence of marital status on overall survival in adult patients with chordoma: a SEER-based studyChao Tang0Ruiliang Wang1Qingguo Lu2Shantao Wang3Gen Jia4Pengfei Cao5Xinfa Nie6Hailong Zhang7Pain Department, Pizhou City People’s Hospital, Xuzhou Medical UniversityNursing Department, Xijing Hospital, Air Force Medical UniversityTrauma Center, Pizhou City People’s Hospital, Xuzhou Medical UniversityTrauma Center, Pizhou City People’s Hospital, Xuzhou Medical UniversityPain Department, Pizhou City People’s Hospital, Xuzhou Medical UniversityPain Department, Pizhou City People’s Hospital, Xuzhou Medical UniversityPain Department, Pizhou City People’s Hospital, Xuzhou Medical UniversityOrthopedic Department, People’s Hospital of Putuo District, Tongji University School of MedicineAbstract Background As a rare primary bone tumor, no studies have reported the relationship between prognosis and marital status in patients with chordoma. Methods We classified patients with chordoma identified from the Surveillance, Epidemiology, and End Results (SEER) database from 1975 to 2016 into four groups: married, divorced/separated, widowed, and single groups. Kaplan-Meier curves with log-rank test and Cox regression were used to analyze the effect of marital status on overall survival (OS). Results A total of 1080 patients were included in the study: 700 (64.8%) were married, 88 (8.1%) were divorced/separated, 78 (7.2%) were widowed, and 214 (19.8%) were single. Among the 4 groups, the 5-year OS (45.2%), 10-year OS (12.5%), and median OS (56.0 months) were the lowest in the widowed group. After including age, sex, primary site, marital status, disease stage, tumor size, histological type, and treatment pattern, multivariate analysis showed that marital status was still an independent risk factor for patients with chordoma, and widowed patients had the lowest OS (hazard ratio [HR] 1.71; 95% confidence interval [CI] 1.25–2.33, p < 0.001) compared with married patients. Similar results were observed after stratifying the primary site and disease stage. Conclusion Marital status was an independent prognostic indicator for adult patients with chordoma, and marital status was conducive to patient survival. Compared with married patients, widowed patients have a higher risk of death.http://link.springer.com/article/10.1186/s13018-020-01803-6ChordomaMarital statusOverall survivalPrognosisSEER |
| spellingShingle | Chao Tang Ruiliang Wang Qingguo Lu Shantao Wang Gen Jia Pengfei Cao Xinfa Nie Hailong Zhang Influence of marital status on overall survival in adult patients with chordoma: a SEER-based study Journal of Orthopaedic Surgery and Research Chordoma Marital status Overall survival Prognosis SEER |
| title | Influence of marital status on overall survival in adult patients with chordoma: a SEER-based study |
| title_full | Influence of marital status on overall survival in adult patients with chordoma: a SEER-based study |
| title_fullStr | Influence of marital status on overall survival in adult patients with chordoma: a SEER-based study |
| title_full_unstemmed | Influence of marital status on overall survival in adult patients with chordoma: a SEER-based study |
| title_short | Influence of marital status on overall survival in adult patients with chordoma: a SEER-based study |
| title_sort | influence of marital status on overall survival in adult patients with chordoma a seer based study |
| topic | Chordoma Marital status Overall survival Prognosis SEER |
| url | http://link.springer.com/article/10.1186/s13018-020-01803-6 |
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