Assessing different diagnostic tests for gastroesophageal reflux disease: a systematic review and network meta-analysis
Background: The aim of the current systematic review and network meta-analysis (NMA) was to assess the diagnostic characteristics of the gastroesophageal reflux disease questionnaire (GERDQ), proton-pump inhibitor (PPI) test, baseline impedance, mucosal impedance, dilated intercellular spaces (DIS),...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-11-01
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| Series: | Therapeutic Advances in Gastroenterology |
| Online Access: | https://doi.org/10.1177/1756284819890537 |
| _version_ | 1828928733817339904 |
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| author | Mengyu Zhang John E. Pandolfino Xuyu Zhou Niandi Tan Yuwen Li Minhu Chen Yinglian Xiao |
| author_facet | Mengyu Zhang John E. Pandolfino Xuyu Zhou Niandi Tan Yuwen Li Minhu Chen Yinglian Xiao |
| author_sort | Mengyu Zhang |
| collection | DOAJ |
| description | Background: The aim of the current systematic review and network meta-analysis (NMA) was to assess the diagnostic characteristics of the gastroesophageal reflux disease questionnaire (GERDQ), proton-pump inhibitor (PPI) test, baseline impedance, mucosal impedance, dilated intercellular spaces (DIS), salivary pepsin, esophageal pH/pH impedance monitoring and endoscopy for gastroesophageal reflux disease (GERD). Methods: We searched PubMed and the Cochrane Controlled Trial Register database (from inception to 10 April 2018) for studies assessing the diagnostic characteristics of the GERDQ, PPI test, baseline impedance, mucosal impedance, DIS, or salivary pepsin and esophageal pH/pH impedance monitoring/endoscopy in patients with GERD. Direct pairwise comparison and a NMA using Bayesian methods under random effects were performed. We also assessed the ranking probability. Results: A total of 40 studies were identified. The NMA found no significant difference among the baseline impedance, mucosal impedance, and esophageal pH/pH impedance monitoring and endoscopy in terms of both sensitivity and specificity. It was also demonstrated that the salivary pepsin detected by the Peptest device had comparable specificity to esophageal pH/pH impedance monitoring and endoscopy. Results of ranking probability indicated that esophageal pH/pH impedance monitoring and endoscopy had highest sensitivity and specificity, followed by mucosal impedance and baseline impedance, whereas GERDQ had the lowest sensitivity and PPI test had the lowest specificity. Conclusions: In a systematic review and NMA of studies of patients with GERD, we found that baseline impedance and mucosal impedance have relatively high diagnostic performance, similar to esophageal pH/pH impedance monitoring and endoscopy. |
| first_indexed | 2024-12-14T00:09:09Z |
| format | Article |
| id | doaj.art-0ad7a6fb15d648cea39a2696fb056b00 |
| institution | Directory Open Access Journal |
| issn | 1756-2848 |
| language | English |
| last_indexed | 2024-12-14T00:09:09Z |
| publishDate | 2019-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Gastroenterology |
| spelling | doaj.art-0ad7a6fb15d648cea39a2696fb056b002022-12-21T23:25:50ZengSAGE PublishingTherapeutic Advances in Gastroenterology1756-28482019-11-011210.1177/1756284819890537Assessing different diagnostic tests for gastroesophageal reflux disease: a systematic review and network meta-analysisMengyu ZhangJohn E. PandolfinoXuyu ZhouNiandi TanYuwen LiMinhu ChenYinglian XiaoBackground: The aim of the current systematic review and network meta-analysis (NMA) was to assess the diagnostic characteristics of the gastroesophageal reflux disease questionnaire (GERDQ), proton-pump inhibitor (PPI) test, baseline impedance, mucosal impedance, dilated intercellular spaces (DIS), salivary pepsin, esophageal pH/pH impedance monitoring and endoscopy for gastroesophageal reflux disease (GERD). Methods: We searched PubMed and the Cochrane Controlled Trial Register database (from inception to 10 April 2018) for studies assessing the diagnostic characteristics of the GERDQ, PPI test, baseline impedance, mucosal impedance, DIS, or salivary pepsin and esophageal pH/pH impedance monitoring/endoscopy in patients with GERD. Direct pairwise comparison and a NMA using Bayesian methods under random effects were performed. We also assessed the ranking probability. Results: A total of 40 studies were identified. The NMA found no significant difference among the baseline impedance, mucosal impedance, and esophageal pH/pH impedance monitoring and endoscopy in terms of both sensitivity and specificity. It was also demonstrated that the salivary pepsin detected by the Peptest device had comparable specificity to esophageal pH/pH impedance monitoring and endoscopy. Results of ranking probability indicated that esophageal pH/pH impedance monitoring and endoscopy had highest sensitivity and specificity, followed by mucosal impedance and baseline impedance, whereas GERDQ had the lowest sensitivity and PPI test had the lowest specificity. Conclusions: In a systematic review and NMA of studies of patients with GERD, we found that baseline impedance and mucosal impedance have relatively high diagnostic performance, similar to esophageal pH/pH impedance monitoring and endoscopy.https://doi.org/10.1177/1756284819890537 |
| spellingShingle | Mengyu Zhang John E. Pandolfino Xuyu Zhou Niandi Tan Yuwen Li Minhu Chen Yinglian Xiao Assessing different diagnostic tests for gastroesophageal reflux disease: a systematic review and network meta-analysis Therapeutic Advances in Gastroenterology |
| title | Assessing different diagnostic tests for gastroesophageal reflux disease: a systematic review and network meta-analysis |
| title_full | Assessing different diagnostic tests for gastroesophageal reflux disease: a systematic review and network meta-analysis |
| title_fullStr | Assessing different diagnostic tests for gastroesophageal reflux disease: a systematic review and network meta-analysis |
| title_full_unstemmed | Assessing different diagnostic tests for gastroesophageal reflux disease: a systematic review and network meta-analysis |
| title_short | Assessing different diagnostic tests for gastroesophageal reflux disease: a systematic review and network meta-analysis |
| title_sort | assessing different diagnostic tests for gastroesophageal reflux disease a systematic review and network meta analysis |
| url | https://doi.org/10.1177/1756284819890537 |
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