Shared Patterns of Brain Functional Connectivity for the Comorbidity between Migraine and Insomnia
Migraine is commonly comorbid with insomnia; both disorders are linked to functional disturbance of the default mode network (DMN). Evidence suggests that DMN could be segregated into multiple subnetworks with specific roles that underline different cognitive processes. However, the relative contrib...
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| Format: | Article |
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MDPI AG
2021-10-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/10/1420 |
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| author | Kun-Hsien Chou Chen-Yuan Kuo Chih-Sung Liang Pei-Lin Lee Chia-Kuang Tsai Chia-Lin Tsai Ming-Hao Huang Yi-Chih Hsu Guan-Yu Lin Yu-Kai Lin Ching-Po Lin Fu-Chi Yang |
| author_facet | Kun-Hsien Chou Chen-Yuan Kuo Chih-Sung Liang Pei-Lin Lee Chia-Kuang Tsai Chia-Lin Tsai Ming-Hao Huang Yi-Chih Hsu Guan-Yu Lin Yu-Kai Lin Ching-Po Lin Fu-Chi Yang |
| author_sort | Kun-Hsien Chou |
| collection | DOAJ |
| description | Migraine is commonly comorbid with insomnia; both disorders are linked to functional disturbance of the default mode network (DMN). Evidence suggests that DMN could be segregated into multiple subnetworks with specific roles that underline different cognitive processes. However, the relative contributions of DMN subnetworks in the comorbidity of migraine and insomnia remain largely unknown. This study sought to identify altered functional connectivity (FC) profiles of DMN subnetworks in the comorbidity of migraine and insomnia. Direct group comparisons with healthy controls, followed by conjunction analyses, were used to identify shared FC alterations of DMN subnetworks. The shared FC changes of the DMN subnetworks in the migraine and insomnia groups were identified in the dorsomedial prefrontal and posteromedial cortex subnetworks. These shared FC changes were primarily associated with motor and somatosensory systems, and consistently found in patients with comorbid migraine and insomnia. Additionally, the magnitude of FC between the posteromedial cortex and postcentral gyrus correlated with insomnia duration in patients with comorbid migraine and insomnia. Our findings point to specific FC alterations of the DMN subnetwork in migraine and insomnia. The shared patterns of FC disturbance may be associated with the underlying mechanisms of the comorbidity of the two disorders. |
| first_indexed | 2024-03-10T06:42:03Z |
| format | Article |
| id | doaj.art-0ad7ec7a4b1543f690577faeb8126eb2 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T06:42:03Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-0ad7ec7a4b1543f690577faeb8126eb22023-11-22T17:31:39ZengMDPI AGBiomedicines2227-90592021-10-01910142010.3390/biomedicines9101420Shared Patterns of Brain Functional Connectivity for the Comorbidity between Migraine and InsomniaKun-Hsien Chou0Chen-Yuan Kuo1Chih-Sung Liang2Pei-Lin Lee3Chia-Kuang Tsai4Chia-Lin Tsai5Ming-Hao Huang6Yi-Chih Hsu7Guan-Yu Lin8Yu-Kai Lin9Ching-Po Lin10Fu-Chi Yang11Brain Research Center, National Yang Ming Chiao Tung University, Taipei 112, TaiwanAging and Health Research Center, National Yang Ming Chiao Tung University, Taipei 112, TaiwanNational Defense Medical Center, Department of Psychiatry, Beitou Branch, Tri-Service General Hospital, Taipei 112, TaiwanInstitute of Neuroscience, National Yang Ming Chiao Tung University, Taipei 112, TaiwanNational Defense Medical Center, Department of Neurology, Tri-Service General Hospital, Taipei 114, TaiwanNational Defense Medical Center, Department of Neurology, Tri-Service General Hospital, Taipei 114, TaiwanInstitute of Neuroscience, National Yang Ming Chiao Tung University, Taipei 112, TaiwanNational Defense Medical Center, Graduate Institute of Medical Sciences, Taipei 114, TaiwanNational Defense Medical Center, Department of Neurology, Tri-Service General Hospital, Taipei 114, TaiwanNational Defense Medical Center, Department of Neurology, Tri-Service General Hospital, Taipei 114, TaiwanBrain Research Center, National Yang Ming Chiao Tung University, Taipei 112, TaiwanNational Defense Medical Center, Department of Neurology, Tri-Service General Hospital, Taipei 114, TaiwanMigraine is commonly comorbid with insomnia; both disorders are linked to functional disturbance of the default mode network (DMN). Evidence suggests that DMN could be segregated into multiple subnetworks with specific roles that underline different cognitive processes. However, the relative contributions of DMN subnetworks in the comorbidity of migraine and insomnia remain largely unknown. This study sought to identify altered functional connectivity (FC) profiles of DMN subnetworks in the comorbidity of migraine and insomnia. Direct group comparisons with healthy controls, followed by conjunction analyses, were used to identify shared FC alterations of DMN subnetworks. The shared FC changes of the DMN subnetworks in the migraine and insomnia groups were identified in the dorsomedial prefrontal and posteromedial cortex subnetworks. These shared FC changes were primarily associated with motor and somatosensory systems, and consistently found in patients with comorbid migraine and insomnia. Additionally, the magnitude of FC between the posteromedial cortex and postcentral gyrus correlated with insomnia duration in patients with comorbid migraine and insomnia. Our findings point to specific FC alterations of the DMN subnetwork in migraine and insomnia. The shared patterns of FC disturbance may be associated with the underlying mechanisms of the comorbidity of the two disorders.https://www.mdpi.com/2227-9059/9/10/1420default mode networkinsomniamigraineconnectivitysomatosensory |
| spellingShingle | Kun-Hsien Chou Chen-Yuan Kuo Chih-Sung Liang Pei-Lin Lee Chia-Kuang Tsai Chia-Lin Tsai Ming-Hao Huang Yi-Chih Hsu Guan-Yu Lin Yu-Kai Lin Ching-Po Lin Fu-Chi Yang Shared Patterns of Brain Functional Connectivity for the Comorbidity between Migraine and Insomnia Biomedicines default mode network insomnia migraine connectivity somatosensory |
| title | Shared Patterns of Brain Functional Connectivity for the Comorbidity between Migraine and Insomnia |
| title_full | Shared Patterns of Brain Functional Connectivity for the Comorbidity between Migraine and Insomnia |
| title_fullStr | Shared Patterns of Brain Functional Connectivity for the Comorbidity between Migraine and Insomnia |
| title_full_unstemmed | Shared Patterns of Brain Functional Connectivity for the Comorbidity between Migraine and Insomnia |
| title_short | Shared Patterns of Brain Functional Connectivity for the Comorbidity between Migraine and Insomnia |
| title_sort | shared patterns of brain functional connectivity for the comorbidity between migraine and insomnia |
| topic | default mode network insomnia migraine connectivity somatosensory |
| url | https://www.mdpi.com/2227-9059/9/10/1420 |
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