<i>CLOCK</i> Gene Variation Is Associated with the Incidence of Metabolic Syndrome Modulated by Monounsaturated Fatty Acids
The circadian locomotor output cycles kaput (<i>CLOCK</i>) gene plays a crucial role in regulating circadian rhythms through its transcription factor gene product. The objective of this study was to investigate the association between <i>CLOCK</i> rs1801260 and the incidence...
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MDPI AG
2021-05-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/11/5/412 |
| _version_ | 1797534143995707392 |
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| author | Dayeon Shin Kyung-Won Lee |
| author_facet | Dayeon Shin Kyung-Won Lee |
| author_sort | Dayeon Shin |
| collection | DOAJ |
| description | The circadian locomotor output cycles kaput (<i>CLOCK</i>) gene plays a crucial role in regulating circadian rhythms through its transcription factor gene product. The objective of this study was to investigate the association between <i>CLOCK</i> rs1801260 and the incidence of metabolic syndrome modulated by dietary monounsaturated fatty acid (MUFA) intake in Korean adults. Using a dataset from the Ansan-Ansung Cohort Study of the Korean Genome and Epidemiology Study, 3608 Korean adults were included after an average of nine years of follow-up. Men who were minor allele carriers (G allele) of <i>CLOCK</i> rs1801260 had a 18% higher incidence of metabolic syndrome than non-carriers [hazard ratio (HR), 1.18; 95% confidence interval (CI), 1.00–1.40; <i>p</i> Value = 0.047]. By dichotomizing dietary MUFA intake, we observed that men who were minor allele carriers (G allele) of <i>CLOCK</i> rs1801260 had a 42% increased incidence of metabolic syndrome when dietary MUFA intake was ≤3.5% (HR: 1.42, 95% CI 1.23–1.81; <i>p</i> Value = 0.004). No significant association was found between <i>CLOCK</i> rs1801260 and the incidence of metabolic syndrome modulated by dietary MUFA intake in women. <i>CLOCK</i> polymorphisms affected metabolic syndrome, modulated by dietary MUFA intake in men. These results suggest the significance of <i>CLOCK</i> genes in the pathogenesis of metabolic syndrome and the modulating role of dietary MUFA intake and provide new insights into the underlying mechanisms connecting the circadian system, dietary factors, and metabolic syndrome. |
| first_indexed | 2024-03-10T11:25:28Z |
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| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T11:25:28Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
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| series | Journal of Personalized Medicine |
| spelling | doaj.art-0ad9542a50ac4f2c8b65f093b6a5071a2023-11-21T19:41:01ZengMDPI AGJournal of Personalized Medicine2075-44262021-05-0111541210.3390/jpm11050412<i>CLOCK</i> Gene Variation Is Associated with the Incidence of Metabolic Syndrome Modulated by Monounsaturated Fatty AcidsDayeon Shin0Kyung-Won Lee1Department of Food and Nutrition, Inha University, Incheon 22212, KoreaDepartment of Home Economics Education, Korea National University of Education, Cheongju 28173, KoreaThe circadian locomotor output cycles kaput (<i>CLOCK</i>) gene plays a crucial role in regulating circadian rhythms through its transcription factor gene product. The objective of this study was to investigate the association between <i>CLOCK</i> rs1801260 and the incidence of metabolic syndrome modulated by dietary monounsaturated fatty acid (MUFA) intake in Korean adults. Using a dataset from the Ansan-Ansung Cohort Study of the Korean Genome and Epidemiology Study, 3608 Korean adults were included after an average of nine years of follow-up. Men who were minor allele carriers (G allele) of <i>CLOCK</i> rs1801260 had a 18% higher incidence of metabolic syndrome than non-carriers [hazard ratio (HR), 1.18; 95% confidence interval (CI), 1.00–1.40; <i>p</i> Value = 0.047]. By dichotomizing dietary MUFA intake, we observed that men who were minor allele carriers (G allele) of <i>CLOCK</i> rs1801260 had a 42% increased incidence of metabolic syndrome when dietary MUFA intake was ≤3.5% (HR: 1.42, 95% CI 1.23–1.81; <i>p</i> Value = 0.004). No significant association was found between <i>CLOCK</i> rs1801260 and the incidence of metabolic syndrome modulated by dietary MUFA intake in women. <i>CLOCK</i> polymorphisms affected metabolic syndrome, modulated by dietary MUFA intake in men. These results suggest the significance of <i>CLOCK</i> genes in the pathogenesis of metabolic syndrome and the modulating role of dietary MUFA intake and provide new insights into the underlying mechanisms connecting the circadian system, dietary factors, and metabolic syndrome.https://www.mdpi.com/2075-4426/11/5/412<i>CLOCK</i> polymorphismsmetabolic syndromedietary monounsaturated fatty acidsKorean Genome and Epidemiology Study (KoGES) |
| spellingShingle | Dayeon Shin Kyung-Won Lee <i>CLOCK</i> Gene Variation Is Associated with the Incidence of Metabolic Syndrome Modulated by Monounsaturated Fatty Acids Journal of Personalized Medicine <i>CLOCK</i> polymorphisms metabolic syndrome dietary monounsaturated fatty acids Korean Genome and Epidemiology Study (KoGES) |
| title | <i>CLOCK</i> Gene Variation Is Associated with the Incidence of Metabolic Syndrome Modulated by Monounsaturated Fatty Acids |
| title_full | <i>CLOCK</i> Gene Variation Is Associated with the Incidence of Metabolic Syndrome Modulated by Monounsaturated Fatty Acids |
| title_fullStr | <i>CLOCK</i> Gene Variation Is Associated with the Incidence of Metabolic Syndrome Modulated by Monounsaturated Fatty Acids |
| title_full_unstemmed | <i>CLOCK</i> Gene Variation Is Associated with the Incidence of Metabolic Syndrome Modulated by Monounsaturated Fatty Acids |
| title_short | <i>CLOCK</i> Gene Variation Is Associated with the Incidence of Metabolic Syndrome Modulated by Monounsaturated Fatty Acids |
| title_sort | i clock i gene variation is associated with the incidence of metabolic syndrome modulated by monounsaturated fatty acids |
| topic | <i>CLOCK</i> polymorphisms metabolic syndrome dietary monounsaturated fatty acids Korean Genome and Epidemiology Study (KoGES) |
| url | https://www.mdpi.com/2075-4426/11/5/412 |
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