Galanin promotes autophagy and alleviates apoptosis in the hypertrophied heart through FoxO1 pathway

Galanin promotes autophagy and alleviates apoptosis in the hypertrophied heart through FoxO1 pathway

Autophagy and apoptosis are powerful regulators of multiple facets of cellular metabolism and homeostasis. Here, we uncover that galanin, a pleiotropic peptide, regulates cardiac autophagy and deactivates apoptotic cell death through the Forkhead box protein O1 (FoxO1) pathway. In hypertrophied hear...

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Bibliographic Details
Main Authors: Ilenia Martinelli, Andrei Timotin, Paula Moreno-Corchado, Dimitri Marsal, Solomiia Kramar, Halina Loy, Carine Joffre, Frederic Boal, Helene Tronchere, Oksana Kunduzova
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Redox Biology
Subjects:
Galanin
Autophagy
Hypertrophy
Cardiac remodeling
Metabolism
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721000148

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