Cinnamon oil against acetaminophen-induced acute liver toxicity by attenuating inflammation, oxidative stress and apoptosis

Cinnamon oil against acetaminophen-induced acute liver toxicity by attenuating inflammation, oxidative stress and apoptosis

Acetaminophen (APAP) is used as a primary drug due to its antipyretic and analgesic activity. The mechanism of action of APAP toxicity in the liver is due to the depletion of glutathione which elicited free radicals generation. Therefore, the objective of our work is to investigate the APAP induced...

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Bibliographic Details
Main Authors: Sohail Hussain, Mohammed Ashafaq, Saeed Alshahrani, Rahimullah Siddiqui, Rayan A. Ahmed, Gulrana Khuwaja, Fakhrul Islam
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Toxicology Reports
Subjects:
Acetaminophen
Cinnamon oil
Hepatotoxicity
Oxidative stress
DNA fragmentation
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750020304029

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