PHARMACEUTICAL PROPERTIES OF VENOM TOXINS AND THEIR POTENTIAL IN DRUG DISCOVERY
Traditional pipelines feeding drugs coming to the market are declining. This is one of the reasons why nowadays the previous ly abandoned natural extract drug discovery programs are slowly coming back. In this scenario, small molecular metabolites from plants and single cell marine or soil organ...
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| Format: | Article |
| Language: | English |
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Universitas Gadjah Mada
2016-01-01
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| Series: | Indonesian Journal of Pharmacy |
| Subjects: | |
| Online Access: | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1025 |
| Summary: | Traditional pipelines feeding drugs coming to the market are
declining. This is one of the reasons why nowadays the previous ly
abandoned natural extract drug discovery programs are slowly
coming back. In this scenario, small molecular metabolites from
plants and single cell marine or soil organisms are gaining interest
in pharmaceutical research again. Animal venoms are another
source for finding new biopharmaceutical lead molecules and
research interest in discovering bioactive molecules from venoms
is rising. Venoms comprise often highly selective and potent
bioactive peptides and small proteins for receptors and enzymes
that are valid drug targets. This work discusses drug discovery
research on bioactive compounds in venoms and gives older and
more recent examples of bioactive compounds found in venoms
from different animals. Common pharmaceutical targets that
different classes of venom toxins interact with and information on
developmental stages of several medicinal venom peptides are
also discussed. |
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| ISSN: | 2338-9427 2338-9486 |