PHARMACEUTICAL PROPERTIES OF VENOM TOXINS AND THEIR POTENTIAL IN DRUG DISCOVERY
Traditional pipelines feeding drugs coming to the market are declining. This is one of the reasons why nowadays the previous ly abandoned natural extract drug discovery programs are slowly coming back. In this scenario, small molecular metabolites from plants and single cell marine or soil organ...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universitas Gadjah Mada
2016-01-01
|
| Series: | Indonesian Journal of Pharmacy |
| Subjects: | |
| Online Access: | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1025 |
| _version_ | 1818648130949742592 |
|---|---|
| author | Jeroen Kool |
| author_facet | Jeroen Kool |
| author_sort | Jeroen Kool |
| collection | DOAJ |
| description | Traditional pipelines feeding drugs coming to the market are
declining. This is one of the reasons why nowadays the previous ly
abandoned natural extract drug discovery programs are slowly
coming back. In this scenario, small molecular metabolites from
plants and single cell marine or soil organisms are gaining interest
in pharmaceutical research again. Animal venoms are another
source for finding new biopharmaceutical lead molecules and
research interest in discovering bioactive molecules from venoms
is rising. Venoms comprise often highly selective and potent
bioactive peptides and small proteins for receptors and enzymes
that are valid drug targets. This work discusses drug discovery
research on bioactive compounds in venoms and gives older and
more recent examples of bioactive compounds found in venoms
from different animals. Common pharmaceutical targets that
different classes of venom toxins interact with and information on
developmental stages of several medicinal venom peptides are
also discussed. |
| first_indexed | 2024-12-17T01:13:33Z |
| format | Article |
| id | doaj.art-0ade3b5ee5c54c6ab572ddbb4660f003 |
| institution | Directory Open Access Journal |
| issn | 2338-9427 2338-9486 |
| language | English |
| last_indexed | 2024-12-17T01:13:33Z |
| publishDate | 2016-01-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Pharmacy |
| spelling | doaj.art-0ade3b5ee5c54c6ab572ddbb4660f0032022-12-21T22:09:04ZengUniversitas Gadjah MadaIndonesian Journal of Pharmacy2338-94272338-94862016-01-012711810.14499/indonesianjpharm27iss1pp1PHARMACEUTICAL PROPERTIES OF VENOM TOXINS AND THEIR POTENTIAL IN DRUG DISCOVERYJeroen Kool0Division of BioAnalytical Chemistry, Department of Chemistry and Pharmaceutical Sciences, Faculty of Sciences, VU University Amsterdam, Amsterdam, NetherlandTraditional pipelines feeding drugs coming to the market are declining. This is one of the reasons why nowadays the previous ly abandoned natural extract drug discovery programs are slowly coming back. In this scenario, small molecular metabolites from plants and single cell marine or soil organisms are gaining interest in pharmaceutical research again. Animal venoms are another source for finding new biopharmaceutical lead molecules and research interest in discovering bioactive molecules from venoms is rising. Venoms comprise often highly selective and potent bioactive peptides and small proteins for receptors and enzymes that are valid drug targets. This work discusses drug discovery research on bioactive compounds in venoms and gives older and more recent examples of bioactive compounds found in venoms from different animals. Common pharmaceutical targets that different classes of venom toxins interact with and information on developmental stages of several medicinal venom peptides are also discussed.http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1025toxindrugdiscoverypeptidevenom |
| spellingShingle | Jeroen Kool PHARMACEUTICAL PROPERTIES OF VENOM TOXINS AND THEIR POTENTIAL IN DRUG DISCOVERY Indonesian Journal of Pharmacy toxin drugdiscovery peptide venom |
| title | PHARMACEUTICAL PROPERTIES OF VENOM TOXINS AND THEIR POTENTIAL IN DRUG DISCOVERY |
| title_full | PHARMACEUTICAL PROPERTIES OF VENOM TOXINS AND THEIR POTENTIAL IN DRUG DISCOVERY |
| title_fullStr | PHARMACEUTICAL PROPERTIES OF VENOM TOXINS AND THEIR POTENTIAL IN DRUG DISCOVERY |
| title_full_unstemmed | PHARMACEUTICAL PROPERTIES OF VENOM TOXINS AND THEIR POTENTIAL IN DRUG DISCOVERY |
| title_short | PHARMACEUTICAL PROPERTIES OF VENOM TOXINS AND THEIR POTENTIAL IN DRUG DISCOVERY |
| title_sort | pharmaceutical properties of venom toxins and their potential in drug discovery |
| topic | toxin drugdiscovery peptide venom |
| url | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1025 |
| work_keys_str_mv | AT jeroenkool pharmaceuticalpropertiesofvenomtoxinsandtheirpotentialindrugdiscovery |