Controlling Microenvironments with Organs-on-Chips for Osteoarthritis Modelling
Osteoarthritis (OA) remains a prevalent disease affecting more than 20% of the global population, resulting in morbidity and lower quality of life for patients. The study of OA pathophysiology remains predominantly in animal models due to the complexities of mimicking the physiological environment s...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/4/579 |
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| author | Louis Jun Ye Ong Xiwei Fan Antonia Rujia Sun Lin Mei Yi-Chin Toh Indira Prasadam |
| author_facet | Louis Jun Ye Ong Xiwei Fan Antonia Rujia Sun Lin Mei Yi-Chin Toh Indira Prasadam |
| author_sort | Louis Jun Ye Ong |
| collection | DOAJ |
| description | Osteoarthritis (OA) remains a prevalent disease affecting more than 20% of the global population, resulting in morbidity and lower quality of life for patients. The study of OA pathophysiology remains predominantly in animal models due to the complexities of mimicking the physiological environment surrounding the joint tissue. Recent development in microfluidic organ-on-chip (OoC) systems have demonstrated various techniques to mimic and modulate tissue physiological environments. Adaptations of these techniques have demonstrated success in capturing a joint tissue’s tissue physiology for studying the mechanism of OA. Adapting these techniques and strategies can help create human-specific in vitro models that recapitulate the cellular processes involved in OA. This review aims to comprehensively summarise various demonstrations of microfluidic platforms in mimicking joint microenvironments for future platform design iterations. |
| first_indexed | 2024-03-11T09:00:33Z |
| format | Article |
| id | doaj.art-0ade9b21e876458e8472f38357bc3f1c |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T09:00:33Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-0ade9b21e876458e8472f38357bc3f1c2023-11-16T19:44:17ZengMDPI AGCells2073-44092023-02-0112457910.3390/cells12040579Controlling Microenvironments with Organs-on-Chips for Osteoarthritis ModellingLouis Jun Ye Ong0Xiwei Fan1Antonia Rujia Sun2Lin Mei3Yi-Chin Toh4Indira Prasadam5School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane City, QLD 4000, AustraliaSchool of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane City, QLD 4000, AustraliaSchool of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane City, QLD 4000, AustraliaSchool of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane City, QLD 4000, AustraliaSchool of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane City, QLD 4000, AustraliaSchool of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane City, QLD 4000, AustraliaOsteoarthritis (OA) remains a prevalent disease affecting more than 20% of the global population, resulting in morbidity and lower quality of life for patients. The study of OA pathophysiology remains predominantly in animal models due to the complexities of mimicking the physiological environment surrounding the joint tissue. Recent development in microfluidic organ-on-chip (OoC) systems have demonstrated various techniques to mimic and modulate tissue physiological environments. Adaptations of these techniques have demonstrated success in capturing a joint tissue’s tissue physiology for studying the mechanism of OA. Adapting these techniques and strategies can help create human-specific in vitro models that recapitulate the cellular processes involved in OA. This review aims to comprehensively summarise various demonstrations of microfluidic platforms in mimicking joint microenvironments for future platform design iterations.https://www.mdpi.com/2073-4409/12/4/579osteoarthritiscell microenvironmentorgan-on-chipdisease models |
| spellingShingle | Louis Jun Ye Ong Xiwei Fan Antonia Rujia Sun Lin Mei Yi-Chin Toh Indira Prasadam Controlling Microenvironments with Organs-on-Chips for Osteoarthritis Modelling Cells osteoarthritis cell microenvironment organ-on-chip disease models |
| title | Controlling Microenvironments with Organs-on-Chips for Osteoarthritis Modelling |
| title_full | Controlling Microenvironments with Organs-on-Chips for Osteoarthritis Modelling |
| title_fullStr | Controlling Microenvironments with Organs-on-Chips for Osteoarthritis Modelling |
| title_full_unstemmed | Controlling Microenvironments with Organs-on-Chips for Osteoarthritis Modelling |
| title_short | Controlling Microenvironments with Organs-on-Chips for Osteoarthritis Modelling |
| title_sort | controlling microenvironments with organs on chips for osteoarthritis modelling |
| topic | osteoarthritis cell microenvironment organ-on-chip disease models |
| url | https://www.mdpi.com/2073-4409/12/4/579 |
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