Cellular and Humoral Immune Responses to Vaccination for COVID-19 Are Negatively Impacted by Senescent T Cells: A Case Report
Background: Herein, we aimed to follow up on the cellular and humoral immune responses of a group of individuals who initially received the CoronaVac vaccine, followed by a booster with the Pfizer vaccine. Methods: Blood samples were collected: before and 30 days after the first CoronaVac dose; 30,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/11/4/840 |
| _version_ | 1797603262893916160 |
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| author | Eliane Aparecida Rosseto-Welter Silvia Sanches Rodrigues Amanda Braga de Figueiredo Carolina Nunes França Danielle Bruna Leal Oliveira André Luis Lacerda Bachi Jônatas Bussador do Amaral Ricardo Andreotti Siqueira Laiz Camerão Bento Ana Paula da Silva Nydia Strachman Bacal Carlos Eduardo dos Santos Ferreira Cristóvão Luis Pitangueira Mangueira João Renato Rebello Pinho |
| author_facet | Eliane Aparecida Rosseto-Welter Silvia Sanches Rodrigues Amanda Braga de Figueiredo Carolina Nunes França Danielle Bruna Leal Oliveira André Luis Lacerda Bachi Jônatas Bussador do Amaral Ricardo Andreotti Siqueira Laiz Camerão Bento Ana Paula da Silva Nydia Strachman Bacal Carlos Eduardo dos Santos Ferreira Cristóvão Luis Pitangueira Mangueira João Renato Rebello Pinho |
| author_sort | Eliane Aparecida Rosseto-Welter |
| collection | DOAJ |
| description | Background: Herein, we aimed to follow up on the cellular and humoral immune responses of a group of individuals who initially received the CoronaVac vaccine, followed by a booster with the Pfizer vaccine. Methods: Blood samples were collected: before and 30 days after the first CoronaVac dose; 30, 90, and 180 days after the second CoronaVac dose, and also 20 days after the booster with the Pfizer vaccine. Results: Whilst the positivity to gamma interferon-type cellular response increased after the first CoronaVac dose, neutralizing and IgG antibody levels only raised 30 days after the second dose, followed by a drop in these responses after 90 and 180 days. The booster with the Pfizer vaccine elicited a robust cellular and humoral response. A higher number of double-negative and senescent T cells, as well as increased pro-inflammatory cytokines levels were found in the participants with lower humoral immune responses. Conclusion: CoronaVac elicited an early cellular response, followed by a humoral response, which dropped 90 days after the second dose. The booster with the Pfizer vaccine significantly enhanced these responses. Furthermore, a pro-inflammatory systemic status was found in volunteers who presented senescent T cells, which could putatively impair the immune response to vaccination. |
| first_indexed | 2024-03-11T04:26:46Z |
| format | Article |
| id | doaj.art-0ae187687c30445bb9de4a5f36a09ebc |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-11T04:26:46Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-0ae187687c30445bb9de4a5f36a09ebc2023-11-17T21:42:29ZengMDPI AGVaccines2076-393X2023-04-0111484010.3390/vaccines11040840Cellular and Humoral Immune Responses to Vaccination for COVID-19 Are Negatively Impacted by Senescent T Cells: A Case ReportEliane Aparecida Rosseto-Welter0Silvia Sanches Rodrigues1Amanda Braga de Figueiredo2Carolina Nunes França3Danielle Bruna Leal Oliveira4André Luis Lacerda Bachi5Jônatas Bussador do Amaral6Ricardo Andreotti Siqueira7Laiz Camerão Bento8Ana Paula da Silva9Nydia Strachman Bacal10Carlos Eduardo dos Santos Ferreira11Cristóvão Luis Pitangueira Mangueira12João Renato Rebello Pinho13Hospital Israelita Albert Einstein, São Paulo 05652-900, BrazilHospital Israelita Albert Einstein, São Paulo 05652-900, BrazilHospital Israelita Albert Einstein, São Paulo 05652-900, BrazilPost-Graduation Program in Health Sciences, Santo Amaro University, São Paulo 04829-300, BrazilHospital Israelita Albert Einstein, São Paulo 05652-900, BrazilPost-Graduation Program in Health Sciences, Santo Amaro University, São Paulo 04829-300, BrazilENT Research Lab., Department of Otorhinolaryngology Head and Neck Surgery, Federal University of Sao Paulo (UNIFESP), São Paulo 04021-001, BrazilHospital Israelita Albert Einstein, São Paulo 05652-900, BrazilHospital Israelita Albert Einstein, São Paulo 05652-900, BrazilHospital Israelita Albert Einstein, São Paulo 05652-900, BrazilHospital Israelita Albert Einstein, São Paulo 05652-900, BrazilHospital Israelita Albert Einstein, São Paulo 05652-900, BrazilHospital Israelita Albert Einstein, São Paulo 05652-900, BrazilHospital Israelita Albert Einstein, São Paulo 05652-900, BrazilBackground: Herein, we aimed to follow up on the cellular and humoral immune responses of a group of individuals who initially received the CoronaVac vaccine, followed by a booster with the Pfizer vaccine. Methods: Blood samples were collected: before and 30 days after the first CoronaVac dose; 30, 90, and 180 days after the second CoronaVac dose, and also 20 days after the booster with the Pfizer vaccine. Results: Whilst the positivity to gamma interferon-type cellular response increased after the first CoronaVac dose, neutralizing and IgG antibody levels only raised 30 days after the second dose, followed by a drop in these responses after 90 and 180 days. The booster with the Pfizer vaccine elicited a robust cellular and humoral response. A higher number of double-negative and senescent T cells, as well as increased pro-inflammatory cytokines levels were found in the participants with lower humoral immune responses. Conclusion: CoronaVac elicited an early cellular response, followed by a humoral response, which dropped 90 days after the second dose. The booster with the Pfizer vaccine significantly enhanced these responses. Furthermore, a pro-inflammatory systemic status was found in volunteers who presented senescent T cells, which could putatively impair the immune response to vaccination.https://www.mdpi.com/2076-393X/11/4/840CoronaVac vaccinePfizer vaccineimmunophenotypinginflammationneutralizing antibodiescell senescence |
| spellingShingle | Eliane Aparecida Rosseto-Welter Silvia Sanches Rodrigues Amanda Braga de Figueiredo Carolina Nunes França Danielle Bruna Leal Oliveira André Luis Lacerda Bachi Jônatas Bussador do Amaral Ricardo Andreotti Siqueira Laiz Camerão Bento Ana Paula da Silva Nydia Strachman Bacal Carlos Eduardo dos Santos Ferreira Cristóvão Luis Pitangueira Mangueira João Renato Rebello Pinho Cellular and Humoral Immune Responses to Vaccination for COVID-19 Are Negatively Impacted by Senescent T Cells: A Case Report Vaccines CoronaVac vaccine Pfizer vaccine immunophenotyping inflammation neutralizing antibodies cell senescence |
| title | Cellular and Humoral Immune Responses to Vaccination for COVID-19 Are Negatively Impacted by Senescent T Cells: A Case Report |
| title_full | Cellular and Humoral Immune Responses to Vaccination for COVID-19 Are Negatively Impacted by Senescent T Cells: A Case Report |
| title_fullStr | Cellular and Humoral Immune Responses to Vaccination for COVID-19 Are Negatively Impacted by Senescent T Cells: A Case Report |
| title_full_unstemmed | Cellular and Humoral Immune Responses to Vaccination for COVID-19 Are Negatively Impacted by Senescent T Cells: A Case Report |
| title_short | Cellular and Humoral Immune Responses to Vaccination for COVID-19 Are Negatively Impacted by Senescent T Cells: A Case Report |
| title_sort | cellular and humoral immune responses to vaccination for covid 19 are negatively impacted by senescent t cells a case report |
| topic | CoronaVac vaccine Pfizer vaccine immunophenotyping inflammation neutralizing antibodies cell senescence |
| url | https://www.mdpi.com/2076-393X/11/4/840 |
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