Exosomal Transfer of LCP1 Promotes Osteosarcoma Cell Tumorigenesis and Metastasis by Activating the JAK2/STAT3 Signaling Pathway

Exosomal Transfer of LCP1 Promotes Osteosarcoma Cell Tumorigenesis and Metastasis by Activating the JAK2/STAT3 Signaling Pathway

Increasing evidence indicates that lymphocyte cytosolic protein 1 (LCP1) overexpression contributes to tumor progression; however, its role in osteosarcoma (OS) remains unclear. We aimed to investigate the potential effect of LCP1 in OS and the underlying mechanisms. We first demonstrated that LCP1...

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Bibliographic Details
Main Authors: Xuhui Ge, Wei Liu, Wene Zhao, Shuang Feng, Ao Duan, Chengyue Ji, Kai Shen, Wanshun Liu, Jiawen Zhou, Dongdong Jiang, Yuluo Rong, Fangyi Gong, Jiaxing Wang, Zhiyang Xu, Xiaoyan Li, Jin Fan, Yongzhong Wei, Jianling Bai, Weihua Cai
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
osteosarcoma
exosomal LCP1
BMSCs
miR-135a-5p
JAK2/STAT3 pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120302146

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