Fetal Pancreatic Hamartoma Associated with Hepatoblastoma—An Unusual Tumor Association
Abdominal tumor masses are a very rare disease in the fetus. The authors present the first reported case of neonatal multicystic adenomatoid hamartoma of the pancreas associated with well-differentiated fetal epithelial subtype hepatoblastoma and reveal clinical, histologic, and imagistic aspects. C...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/3/758 |
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| author | Valentin Varlas Oana Neagu Andreea Moga Radu Bălănescu Roxana Bohiltea Radu Vladareanu Laura Balanescu |
| author_facet | Valentin Varlas Oana Neagu Andreea Moga Radu Bălănescu Roxana Bohiltea Radu Vladareanu Laura Balanescu |
| author_sort | Valentin Varlas |
| collection | DOAJ |
| description | Abdominal tumor masses are a very rare disease in the fetus. The authors present the first reported case of neonatal multicystic adenomatoid hamartoma of the pancreas associated with well-differentiated fetal epithelial subtype hepatoblastoma and reveal clinical, histologic, and imagistic aspects. Case presentation: A 36-week-old female newborn in whom a 25-week ultrasound showed a relatively homogeneous pancreatic echogenic mass (34 × 30 × 55 mm) with compression of the inferior vena cava and retrograde dilation. Postnatal CT showed a giant pancreatic tumor mass (113 × 70 × 60 mm), with areas enhancing contrast and cystic/necrotic areas and a hypodense, hypocaptive nodule of 8 × 6 mm located at segment IV of the liver; thrombosis of the subhepatic segment of the inferior vena cava and both renal veins. Histopathological and immunohistochemical studies confirmed the diagnosis of multicystic pancreatic adenomatoid hamartoma and well-differentiated fetal epithelial subtype hepatoblastoma. Conclusions: Pancreatic hamartoma can be difficult to diagnose (especially prenatal), with or without nonspecific symptoms. The synchronous presence of hepatoblastoma complicated the therapeutic conduct and prognosis of this case, with the diagnosis being confirmed histopathologically and immunohistochemically after liver biopsy. |
| first_indexed | 2024-03-09T19:55:41Z |
| format | Article |
| id | doaj.art-0ae291ace1454865b0ed5b19e0c97fd6 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T19:55:41Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-0ae291ace1454865b0ed5b19e0c97fd62023-11-24T00:56:36ZengMDPI AGDiagnostics2075-44182022-03-0112375810.3390/diagnostics12030758Fetal Pancreatic Hamartoma Associated with Hepatoblastoma—An Unusual Tumor AssociationValentin Varlas0Oana Neagu1Andreea Moga2Radu Bălănescu3Roxana Bohiltea4Radu Vladareanu5Laura Balanescu6Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, 011171 Bucharest, RomaniaDepartment of Anatomopathology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Pediatric Surgery, Children Emergency Hospital “Grigore Alexandrescu”, 011743 Bucharest, RomaniaFaculty of General Medicine, “Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu St., 020021 Bucharest, RomaniaDepartment of Obstetrics and Gynecology, Filantropia Clinical Hospital, 011171 Bucharest, RomaniaFaculty of General Medicine, “Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu St., 020021 Bucharest, RomaniaFaculty of General Medicine, “Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu St., 020021 Bucharest, RomaniaAbdominal tumor masses are a very rare disease in the fetus. The authors present the first reported case of neonatal multicystic adenomatoid hamartoma of the pancreas associated with well-differentiated fetal epithelial subtype hepatoblastoma and reveal clinical, histologic, and imagistic aspects. Case presentation: A 36-week-old female newborn in whom a 25-week ultrasound showed a relatively homogeneous pancreatic echogenic mass (34 × 30 × 55 mm) with compression of the inferior vena cava and retrograde dilation. Postnatal CT showed a giant pancreatic tumor mass (113 × 70 × 60 mm), with areas enhancing contrast and cystic/necrotic areas and a hypodense, hypocaptive nodule of 8 × 6 mm located at segment IV of the liver; thrombosis of the subhepatic segment of the inferior vena cava and both renal veins. Histopathological and immunohistochemical studies confirmed the diagnosis of multicystic pancreatic adenomatoid hamartoma and well-differentiated fetal epithelial subtype hepatoblastoma. Conclusions: Pancreatic hamartoma can be difficult to diagnose (especially prenatal), with or without nonspecific symptoms. The synchronous presence of hepatoblastoma complicated the therapeutic conduct and prognosis of this case, with the diagnosis being confirmed histopathologically and immunohistochemically after liver biopsy.https://www.mdpi.com/2075-4418/12/3/758fetal abdominal massfetal pancreatic tumorshamartomahepatoblastomaultrasonographyfetal inferior vena cava anomalies |
| spellingShingle | Valentin Varlas Oana Neagu Andreea Moga Radu Bălănescu Roxana Bohiltea Radu Vladareanu Laura Balanescu Fetal Pancreatic Hamartoma Associated with Hepatoblastoma—An Unusual Tumor Association Diagnostics fetal abdominal mass fetal pancreatic tumors hamartoma hepatoblastoma ultrasonography fetal inferior vena cava anomalies |
| title | Fetal Pancreatic Hamartoma Associated with Hepatoblastoma—An Unusual Tumor Association |
| title_full | Fetal Pancreatic Hamartoma Associated with Hepatoblastoma—An Unusual Tumor Association |
| title_fullStr | Fetal Pancreatic Hamartoma Associated with Hepatoblastoma—An Unusual Tumor Association |
| title_full_unstemmed | Fetal Pancreatic Hamartoma Associated with Hepatoblastoma—An Unusual Tumor Association |
| title_short | Fetal Pancreatic Hamartoma Associated with Hepatoblastoma—An Unusual Tumor Association |
| title_sort | fetal pancreatic hamartoma associated with hepatoblastoma an unusual tumor association |
| topic | fetal abdominal mass fetal pancreatic tumors hamartoma hepatoblastoma ultrasonography fetal inferior vena cava anomalies |
| url | https://www.mdpi.com/2075-4418/12/3/758 |
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