Trends of correlations between serum levels of growth hormone and insulin-like growth factor-I in general practice
Serum levels of growth hormone (GH) and insulin-like growth factor (IGF)-I are crucial in the diagnosis and management of GH-related diseases. However, these levels are affected by nutritional and metabolic status. To elucidate the correlations between GH and IGF-I in various conditions, a retrospec...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-03-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1381083/full |
| _version_ | 1797244957519511552 |
|---|---|
| author | Kohei Oguni Koichiro Yamamoto Yasuhiro Nakano Yoshiaki Soejima Atsuhito Suyama Ryosuke Takase Miho Yasuda Kou Hasegawa Fumio Otsuka |
| author_facet | Kohei Oguni Koichiro Yamamoto Yasuhiro Nakano Yoshiaki Soejima Atsuhito Suyama Ryosuke Takase Miho Yasuda Kou Hasegawa Fumio Otsuka |
| author_sort | Kohei Oguni |
| collection | DOAJ |
| description | Serum levels of growth hormone (GH) and insulin-like growth factor (IGF)-I are crucial in the diagnosis and management of GH-related diseases. However, these levels are affected by nutritional and metabolic status. To elucidate the correlations between GH and IGF-I in various conditions, a retrospective analysis was performed for adult patients in which GH levels were examined by general practitioners during the period from January 2019 to December 2021. Of 642 patients, 33 patients were diagnosed with acromegaly, 21 were diagnosed with GH deficiency (GHD), and 588 were diagnosed with non-GH-related diseases (NGRD). In contrast to the positive correlations found between the levels of GH and IGF-I in patients with acromegaly (R=0.50; P<0.001) and patients with GHD (R=0.39; P=0.08), a negative correlation was found in the NGRD group (R=-0.23; P<0.001). In that group, the results of multivariable analysis showed that GH levels were predominantly influenced by gender and body mass index (BMI), whereas IGF-I levels were modulated by albumin in addition to age and GH. Of note, in the NGRD group, there was an enhanced negative correlation between GH and IGF-I under conditions of BMI < 22 and albumin < 4.0 g/dL (R=-0.45; P<0.001), and the negative correlation between GH and IGF-I was reinforced by excluding patients with other pituitary diseases and patients taking oral steroids (R=-0.51; P<0.001 and R=-0.59; P<0.001, respectively). Collectively, the results indicate that attention should be given to the presence of a negative correlation between serum levels of GH and IGF-I, especially in lean and low-nutritious conditions. |
| first_indexed | 2024-04-24T19:19:16Z |
| format | Article |
| id | doaj.art-0ae43a8ace1d44819a1102d107540ae5 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-24T19:19:16Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-0ae43a8ace1d44819a1102d107540ae52024-03-26T04:22:45ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-03-011510.3389/fendo.2024.13810831381083Trends of correlations between serum levels of growth hormone and insulin-like growth factor-I in general practiceKohei OguniKoichiro YamamotoYasuhiro NakanoYoshiaki SoejimaAtsuhito SuyamaRyosuke TakaseMiho YasudaKou HasegawaFumio OtsukaSerum levels of growth hormone (GH) and insulin-like growth factor (IGF)-I are crucial in the diagnosis and management of GH-related diseases. However, these levels are affected by nutritional and metabolic status. To elucidate the correlations between GH and IGF-I in various conditions, a retrospective analysis was performed for adult patients in which GH levels were examined by general practitioners during the period from January 2019 to December 2021. Of 642 patients, 33 patients were diagnosed with acromegaly, 21 were diagnosed with GH deficiency (GHD), and 588 were diagnosed with non-GH-related diseases (NGRD). In contrast to the positive correlations found between the levels of GH and IGF-I in patients with acromegaly (R=0.50; P<0.001) and patients with GHD (R=0.39; P=0.08), a negative correlation was found in the NGRD group (R=-0.23; P<0.001). In that group, the results of multivariable analysis showed that GH levels were predominantly influenced by gender and body mass index (BMI), whereas IGF-I levels were modulated by albumin in addition to age and GH. Of note, in the NGRD group, there was an enhanced negative correlation between GH and IGF-I under conditions of BMI < 22 and albumin < 4.0 g/dL (R=-0.45; P<0.001), and the negative correlation between GH and IGF-I was reinforced by excluding patients with other pituitary diseases and patients taking oral steroids (R=-0.51; P<0.001 and R=-0.59; P<0.001, respectively). Collectively, the results indicate that attention should be given to the presence of a negative correlation between serum levels of GH and IGF-I, especially in lean and low-nutritious conditions.https://www.frontiersin.org/articles/10.3389/fendo.2024.1381083/fullacromegalygrowth hormone (GH)GH deficiency (GHD)insulin-like growth factor (IGF)-Ipituitary gland |
| spellingShingle | Kohei Oguni Koichiro Yamamoto Yasuhiro Nakano Yoshiaki Soejima Atsuhito Suyama Ryosuke Takase Miho Yasuda Kou Hasegawa Fumio Otsuka Trends of correlations between serum levels of growth hormone and insulin-like growth factor-I in general practice Frontiers in Endocrinology acromegaly growth hormone (GH) GH deficiency (GHD) insulin-like growth factor (IGF)-I pituitary gland |
| title | Trends of correlations between serum levels of growth hormone and insulin-like growth factor-I in general practice |
| title_full | Trends of correlations between serum levels of growth hormone and insulin-like growth factor-I in general practice |
| title_fullStr | Trends of correlations between serum levels of growth hormone and insulin-like growth factor-I in general practice |
| title_full_unstemmed | Trends of correlations between serum levels of growth hormone and insulin-like growth factor-I in general practice |
| title_short | Trends of correlations between serum levels of growth hormone and insulin-like growth factor-I in general practice |
| title_sort | trends of correlations between serum levels of growth hormone and insulin like growth factor i in general practice |
| topic | acromegaly growth hormone (GH) GH deficiency (GHD) insulin-like growth factor (IGF)-I pituitary gland |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1381083/full |
| work_keys_str_mv | AT koheioguni trendsofcorrelationsbetweenserumlevelsofgrowthhormoneandinsulinlikegrowthfactoriingeneralpractice AT koichiroyamamoto trendsofcorrelationsbetweenserumlevelsofgrowthhormoneandinsulinlikegrowthfactoriingeneralpractice AT yasuhironakano trendsofcorrelationsbetweenserumlevelsofgrowthhormoneandinsulinlikegrowthfactoriingeneralpractice AT yoshiakisoejima trendsofcorrelationsbetweenserumlevelsofgrowthhormoneandinsulinlikegrowthfactoriingeneralpractice AT atsuhitosuyama trendsofcorrelationsbetweenserumlevelsofgrowthhormoneandinsulinlikegrowthfactoriingeneralpractice AT ryosuketakase trendsofcorrelationsbetweenserumlevelsofgrowthhormoneandinsulinlikegrowthfactoriingeneralpractice AT mihoyasuda trendsofcorrelationsbetweenserumlevelsofgrowthhormoneandinsulinlikegrowthfactoriingeneralpractice AT kouhasegawa trendsofcorrelationsbetweenserumlevelsofgrowthhormoneandinsulinlikegrowthfactoriingeneralpractice AT fumiootsuka trendsofcorrelationsbetweenserumlevelsofgrowthhormoneandinsulinlikegrowthfactoriingeneralpractice |