Does Cementing Influence CRP and ESR Levels after Total Hip Replacement in Early Postoperative Period? A Prospective Interventional Study
Introduction: The role of C-Reactive Protein (CRP) and Erythrocyte Sedimentation Rate (ESR) in diagnosing delayed (>6 weeks) periprosthetic joint infection prior to performing a revision joint arthroplasty is well established. Aim: To evaluate the effect of bone cement on C-Reactive Protei...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2022-08-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/16779/55984_CE(AD)_F(KR)_PF1(SC_SH)_PFA_PB(SC_KM)_PN(KM).pdf |
| Summary: | Introduction: The role of C-Reactive Protein (CRP) and Erythrocyte
Sedimentation Rate (ESR) in diagnosing delayed (>6 weeks)
periprosthetic joint infection prior to performing a revision joint
arthroplasty is well established.
Aim: To evaluate the effect of bone cement on C-Reactive Protein
(CRP) and Erythrocyte Sedimentation Rate (ESR) in the first
3 weeks after Total Hip Replacement (THR).
Materials and Methods: This prospective interventional study
was conducted in Department of Orthopaedics at Government
Medical College, Chandigarh, India, between June 2014 to
December 2017. Sixteen patients who underwent an uncemented
THR and 15 patients who underwent a hybrid THR were included
in the study. Serum CRP and ESR were measured on the day
before surgery and postoperatively on days 1, 2, 3, 7, 12, and
at 3 weeks. Comparison of ESR and CRP values between the groups were performed using a Student’s t-test. A p-value <0.05
was considered statistically significant.
Results: There was no significant difference between the two
groups with respect to age, gender, indication of surgery, comorbidities, operative time and blood loss. CRP showed a
peak at day two with a mean value of 203.74±46.15 mg/L in the
uncemented group and a mean of 206.10±46.78 mg/L in the
hybrid group, with normalisation by 3 weeks. ESR values showed
a peak on day three with a mean of 94.28±5.97 mm/hour in the
uncemented group and 92.15±6.86 mm/hour in the hybrid group
and remained elevated even at 3 weeks. Statistically, no significant
difference was observed in CRP and ESR values after the usage
of cement in total hip arthroplasty (p-value >0.05 in all cases).
Conclusion: Bone cement does not affect CRP or ESR values
significantly in the early phase after uncomplicated total hip
arthroplasty. |
|---|---|
| ISSN: | 2249-782X 0973-709X |