Mesenchymal stem cell-derived exosome-educated macrophages alleviate systemic lupus erythematosus by promoting efferocytosis and recruitment of IL-17+ regulatory T cell

Mesenchymal stem cell-derived exosome-educated macrophages alleviate systemic lupus erythematosus by promoting efferocytosis and recruitment of IL-17+ regulatory T cell

Abstract Background Anti-inflammatory polarized macrophages are reported to alleviate systemic lupus erythematosus (SLE). Our previous studies have demonstrated that exosomes from adipose-derived stem cells promote the anti-inflammatory polarization of macrophages. However, the possible therapeutic...

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Bibliographic Details
Main Authors: Mingchao Zhang, Takerra K. Johnson-Stephenson, Weiran Wang, Yang Wang, Jing Li, Limin Li, Ke Zen, Xi Chen, Dihan Zhu
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Stem Cell Research & Therapy
Subjects:
Systemic lupus erythematosus
Exosome
Macrophage
microRNA
Regulatory T cell
Online Access:https://doi.org/10.1186/s13287-022-03174-7

Internet

https://doi.org/10.1186/s13287-022-03174-7

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