Anodal high-definition transcranial direct current stimulation reduces heart rate and modulates heart-rate variability in healthy young people: A randomized cross-controlled trial
ObjectiveTo investigate whether anodal high-definition transcranial current stimulation (HD-tDCS) over the left dorsolateral pre-frontal cortex (DLPFC) could modulate the heart rate (HR) and heart-rate variability (HRV) in healthy young people.MethodsForty healthy young people were enrolled in this...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1070157/full |
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| author | Zhongke Gu Wenxiang Chen Qian Lu Jiansong Dai Shugang Hu Kai Xu Yao Geng Ye Zhu Boqing Xu Wenjun Dai Ying Shen |
| author_facet | Zhongke Gu Wenxiang Chen Qian Lu Jiansong Dai Shugang Hu Kai Xu Yao Geng Ye Zhu Boqing Xu Wenjun Dai Ying Shen |
| author_sort | Zhongke Gu |
| collection | DOAJ |
| description | ObjectiveTo investigate whether anodal high-definition transcranial current stimulation (HD-tDCS) over the left dorsolateral pre-frontal cortex (DLPFC) could modulate the heart rate (HR) and heart-rate variability (HRV) in healthy young people.MethodsForty healthy young people were enrolled in this randomized crossover trial. The participants were randomized to receive anodal HD-tDCS (n = 20) or sham HD-tDCS (n = 20) over the left DLPFC with a washout period of 1 week. Electrocardiogram (ECG) data were continuously recorded 20 min before the stimulation, during the session (20 min), and 20 min after the session. HR and the time- and frequency-domain indices of the HRV were measured to investigate the activity of the sympathetic and parasympathetic nervous systems.ResultsAnodal HD-tDCS over the left DLPFC induced a significant decrease in HR and a significant increase in the average of normal-to-normal intervals (AVG NN), low-frequency (LF) power, total power (TP), and LF/high-frequency (HF) ratio in comparison with the sham stimulation and the baseline. However, sham HD-tDCS over the left DLPFC had no significant effect on HR or HRV.ConclusionsAnodal HD-tDCS over the left DLPFC could reduce HR and modulate the HRV in healthy young people. HD-tDCS may show some potential for acutely modulating cardiovascular function. |
| first_indexed | 2024-04-13T10:17:03Z |
| format | Article |
| id | doaj.art-0ae84ded73a641448beb4af6112be20c |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-13T10:17:03Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-0ae84ded73a641448beb4af6112be20c2022-12-22T02:50:40ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-12-01910.3389/fcvm.2022.10701571070157Anodal high-definition transcranial direct current stimulation reduces heart rate and modulates heart-rate variability in healthy young people: A randomized cross-controlled trialZhongke Gu0Wenxiang Chen1Qian Lu2Jiansong Dai3Shugang Hu4Kai Xu5Yao Geng6Ye Zhu7Boqing Xu8Wenjun Dai9Ying Shen10Department of Sport and Health Sciences, Nanjing Sport Institute, Nanjing, ChinaDepartment of Rehabilitation, Children's Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Rehabilitation Medicine, The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University, Suzhou, ChinaDepartment of Sport and Health Sciences, Nanjing Sport Institute, Nanjing, ChinaDepartment of Rehabilitation, The Affiliated Jiangning Hospital With Nanjing Medical University, Nanjing, ChinaDepartment of Sport and Health Sciences, Nanjing Sport Institute, Nanjing, ChinaRehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaRehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaRehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaRehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaRehabilitation Medicine Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaObjectiveTo investigate whether anodal high-definition transcranial current stimulation (HD-tDCS) over the left dorsolateral pre-frontal cortex (DLPFC) could modulate the heart rate (HR) and heart-rate variability (HRV) in healthy young people.MethodsForty healthy young people were enrolled in this randomized crossover trial. The participants were randomized to receive anodal HD-tDCS (n = 20) or sham HD-tDCS (n = 20) over the left DLPFC with a washout period of 1 week. Electrocardiogram (ECG) data were continuously recorded 20 min before the stimulation, during the session (20 min), and 20 min after the session. HR and the time- and frequency-domain indices of the HRV were measured to investigate the activity of the sympathetic and parasympathetic nervous systems.ResultsAnodal HD-tDCS over the left DLPFC induced a significant decrease in HR and a significant increase in the average of normal-to-normal intervals (AVG NN), low-frequency (LF) power, total power (TP), and LF/high-frequency (HF) ratio in comparison with the sham stimulation and the baseline. However, sham HD-tDCS over the left DLPFC had no significant effect on HR or HRV.ConclusionsAnodal HD-tDCS over the left DLPFC could reduce HR and modulate the HRV in healthy young people. HD-tDCS may show some potential for acutely modulating cardiovascular function.https://www.frontiersin.org/articles/10.3389/fcvm.2022.1070157/fullhigh-definition transcranial current stimulationcardiac rhythmheart rateheart-rate variabilitydorsolateral pre-frontal cortex |
| spellingShingle | Zhongke Gu Wenxiang Chen Qian Lu Jiansong Dai Shugang Hu Kai Xu Yao Geng Ye Zhu Boqing Xu Wenjun Dai Ying Shen Anodal high-definition transcranial direct current stimulation reduces heart rate and modulates heart-rate variability in healthy young people: A randomized cross-controlled trial Frontiers in Cardiovascular Medicine high-definition transcranial current stimulation cardiac rhythm heart rate heart-rate variability dorsolateral pre-frontal cortex |
| title | Anodal high-definition transcranial direct current stimulation reduces heart rate and modulates heart-rate variability in healthy young people: A randomized cross-controlled trial |
| title_full | Anodal high-definition transcranial direct current stimulation reduces heart rate and modulates heart-rate variability in healthy young people: A randomized cross-controlled trial |
| title_fullStr | Anodal high-definition transcranial direct current stimulation reduces heart rate and modulates heart-rate variability in healthy young people: A randomized cross-controlled trial |
| title_full_unstemmed | Anodal high-definition transcranial direct current stimulation reduces heart rate and modulates heart-rate variability in healthy young people: A randomized cross-controlled trial |
| title_short | Anodal high-definition transcranial direct current stimulation reduces heart rate and modulates heart-rate variability in healthy young people: A randomized cross-controlled trial |
| title_sort | anodal high definition transcranial direct current stimulation reduces heart rate and modulates heart rate variability in healthy young people a randomized cross controlled trial |
| topic | high-definition transcranial current stimulation cardiac rhythm heart rate heart-rate variability dorsolateral pre-frontal cortex |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1070157/full |
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