Novel Hydrogels of Chitosan and Poly(vinyl alcohol) Reinforced with Inorganic Particles of Bioactive Glass
Chitosan (CS) and poly(vinyl alcohol) (PVA) hydrogels, a polymeric system that shows a broad potential in biomedical applications, were developed. Despite the advantages they present, their mechanical properties are insufficient to support the loads that appear on the body. Thus, it was proposed to...
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| Format: | Article |
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MDPI AG
2021-02-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/5/691 |
| _version_ | 1797395276250480640 |
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| author | O. Sánchez-Aguinagalde Ainhoa Lejardi Emilio Meaurio Rebeca Hernández Carmen Mijangos Jose-Ramon Sarasua |
| author_facet | O. Sánchez-Aguinagalde Ainhoa Lejardi Emilio Meaurio Rebeca Hernández Carmen Mijangos Jose-Ramon Sarasua |
| author_sort | O. Sánchez-Aguinagalde |
| collection | DOAJ |
| description | Chitosan (CS) and poly(vinyl alcohol) (PVA) hydrogels, a polymeric system that shows a broad potential in biomedical applications, were developed. Despite the advantages they present, their mechanical properties are insufficient to support the loads that appear on the body. Thus, it was proposed to reinforce these gels with inorganic glass particles (BG) in order to improve mechanical properties and bioactivity and to see how this reinforcement affects levofloxacin drug release kinetics. Scanning electron microscopy (SEM), X-ray diffraction (XRD), swelling tests, rheology and drug release studies characterized the resulting hydrogels. The experimental results verified the bioactivity of these gels, showed an improvement of the mechanical properties and proved that the added bioactive glass does affect the release kinetics. |
| first_indexed | 2024-03-09T00:32:08Z |
| format | Article |
| id | doaj.art-0aeb754f14b34c15a43c6ab9f96d50f3 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T00:32:08Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-0aeb754f14b34c15a43c6ab9f96d50f32023-12-11T18:23:59ZengMDPI AGPolymers2073-43602021-02-0113569110.3390/polym13050691Novel Hydrogels of Chitosan and Poly(vinyl alcohol) Reinforced with Inorganic Particles of Bioactive GlassO. Sánchez-Aguinagalde0Ainhoa Lejardi1Emilio Meaurio2Rebeca Hernández3Carmen Mijangos4Jose-Ramon Sarasua5Department of Mining-Metallurgy Engineering and Materials Science and POLYMAT, School of Engineering, University of the Basque Country (EHU-UPV), Plaza Ingeniero Torres Quevedo 1, 48013 Bilbao, SpainDepartment of Mining-Metallurgy Engineering and Materials Science and POLYMAT, School of Engineering, University of the Basque Country (EHU-UPV), Plaza Ingeniero Torres Quevedo 1, 48013 Bilbao, SpainDepartment of Mining-Metallurgy Engineering and Materials Science and POLYMAT, School of Engineering, University of the Basque Country (EHU-UPV), Plaza Ingeniero Torres Quevedo 1, 48013 Bilbao, SpainInstituto de Ciencia y Tecnología de Polímeros, CSIC, c/Juan de la Cierva 3, 28006 Madrid, SpainInstituto de Ciencia y Tecnología de Polímeros, CSIC, c/Juan de la Cierva 3, 28006 Madrid, SpainDepartment of Mining-Metallurgy Engineering and Materials Science and POLYMAT, School of Engineering, University of the Basque Country (EHU-UPV), Plaza Ingeniero Torres Quevedo 1, 48013 Bilbao, SpainChitosan (CS) and poly(vinyl alcohol) (PVA) hydrogels, a polymeric system that shows a broad potential in biomedical applications, were developed. Despite the advantages they present, their mechanical properties are insufficient to support the loads that appear on the body. Thus, it was proposed to reinforce these gels with inorganic glass particles (BG) in order to improve mechanical properties and bioactivity and to see how this reinforcement affects levofloxacin drug release kinetics. Scanning electron microscopy (SEM), X-ray diffraction (XRD), swelling tests, rheology and drug release studies characterized the resulting hydrogels. The experimental results verified the bioactivity of these gels, showed an improvement of the mechanical properties and proved that the added bioactive glass does affect the release kinetics.https://www.mdpi.com/2073-4360/13/5/691biodegradablethermosensitiverheological propertiesbioactivitydrug release |
| spellingShingle | O. Sánchez-Aguinagalde Ainhoa Lejardi Emilio Meaurio Rebeca Hernández Carmen Mijangos Jose-Ramon Sarasua Novel Hydrogels of Chitosan and Poly(vinyl alcohol) Reinforced with Inorganic Particles of Bioactive Glass Polymers biodegradable thermosensitive rheological properties bioactivity drug release |
| title | Novel Hydrogels of Chitosan and Poly(vinyl alcohol) Reinforced with Inorganic Particles of Bioactive Glass |
| title_full | Novel Hydrogels of Chitosan and Poly(vinyl alcohol) Reinforced with Inorganic Particles of Bioactive Glass |
| title_fullStr | Novel Hydrogels of Chitosan and Poly(vinyl alcohol) Reinforced with Inorganic Particles of Bioactive Glass |
| title_full_unstemmed | Novel Hydrogels of Chitosan and Poly(vinyl alcohol) Reinforced with Inorganic Particles of Bioactive Glass |
| title_short | Novel Hydrogels of Chitosan and Poly(vinyl alcohol) Reinforced with Inorganic Particles of Bioactive Glass |
| title_sort | novel hydrogels of chitosan and poly vinyl alcohol reinforced with inorganic particles of bioactive glass |
| topic | biodegradable thermosensitive rheological properties bioactivity drug release |
| url | https://www.mdpi.com/2073-4360/13/5/691 |
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