Relationship between Vitamin D Status and Antibody Response to COVID-19 mRNA Vaccination in Healthy Adults
The immune response to vaccination with SARS-CoV-2 vaccines varies greatly from person to person. In addition to age, there is evidence that certain micronutrients influence the immune system, particularly vitamin D. Here, we analysed SARS-CoV-2 IgG and neutralisation potency along with 25-hydroxy-c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/11/1714 |
| _version_ | 1797511051242110976 |
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| author | Thilo Samson Chillon Kamil Demircan Raban Arved Heller Ines Maria Hirschbil-Bremer Joachim Diegmann Manuel Bachmann Arash Moghaddam Lutz Schomburg |
| author_facet | Thilo Samson Chillon Kamil Demircan Raban Arved Heller Ines Maria Hirschbil-Bremer Joachim Diegmann Manuel Bachmann Arash Moghaddam Lutz Schomburg |
| author_sort | Thilo Samson Chillon |
| collection | DOAJ |
| description | The immune response to vaccination with SARS-CoV-2 vaccines varies greatly from person to person. In addition to age, there is evidence that certain micronutrients influence the immune system, particularly vitamin D. Here, we analysed SARS-CoV-2 IgG and neutralisation potency along with 25-hydroxy-cholecalciferol [25(OH)D] concentrations in a cohort of healthy German adults from the time of vaccination over 24 weeks. Contrary to our expectations, no significant differences were found in the dynamic increase or decrease of SARS-CoV-2 IgG as a function of the 25(OH)D status. Furthermore, the response to the first or second vaccination, the maximum SARS-CoV-2 IgG concentrations achieved, and the decline in SARS-CoV-2 IgG concentrations over time were not related to 25(OH)D status. We conclude that the vaccination response, measured as SARS-CoV-2 IgG concentration, does not depend on 25(OH)D status in healthy adults with moderate vitamin D status. |
| first_indexed | 2024-03-10T05:40:53Z |
| format | Article |
| id | doaj.art-0aeb9d53de6b426ba9ae745b9ea36661 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T05:40:53Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-0aeb9d53de6b426ba9ae745b9ea366612023-11-22T22:32:23ZengMDPI AGBiomedicines2227-90592021-11-01911171410.3390/biomedicines9111714Relationship between Vitamin D Status and Antibody Response to COVID-19 mRNA Vaccination in Healthy AdultsThilo Samson Chillon0Kamil Demircan1Raban Arved Heller2Ines Maria Hirschbil-Bremer3Joachim Diegmann4Manuel Bachmann5Arash Moghaddam6Lutz Schomburg7Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, D-10115 Berlin, GermanyInstitute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, D-10115 Berlin, GermanyInstitute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, D-10115 Berlin, GermanyAschaffenburg Trauma and Orthopaedic Research Group, Center for Orthopaedics, Trauma Surgery and Sports Medicine, Hospital Aschaffenburg-Alzenau, D-63739 Aschaffenburg, GermanyAschaffenburg Trauma and Orthopaedic Research Group, Center for Orthopaedics, Trauma Surgery and Sports Medicine, Hospital Aschaffenburg-Alzenau, D-63739 Aschaffenburg, GermanyAschaffenburg Trauma and Orthopaedic Research Group, Center for Orthopaedics, Trauma Surgery and Sports Medicine, Hospital Aschaffenburg-Alzenau, D-63739 Aschaffenburg, GermanyOrthopedic and Trauma Surgery, Frohsinnstraße 12, D-63739 Aschaffenburg, GermanyInstitute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, D-10115 Berlin, GermanyThe immune response to vaccination with SARS-CoV-2 vaccines varies greatly from person to person. In addition to age, there is evidence that certain micronutrients influence the immune system, particularly vitamin D. Here, we analysed SARS-CoV-2 IgG and neutralisation potency along with 25-hydroxy-cholecalciferol [25(OH)D] concentrations in a cohort of healthy German adults from the time of vaccination over 24 weeks. Contrary to our expectations, no significant differences were found in the dynamic increase or decrease of SARS-CoV-2 IgG as a function of the 25(OH)D status. Furthermore, the response to the first or second vaccination, the maximum SARS-CoV-2 IgG concentrations achieved, and the decline in SARS-CoV-2 IgG concentrations over time were not related to 25(OH)D status. We conclude that the vaccination response, measured as SARS-CoV-2 IgG concentration, does not depend on 25(OH)D status in healthy adults with moderate vitamin D status.https://www.mdpi.com/2227-9059/9/11/1714vitaminsvaccinehumoral responseSARS-CoV-2immunologynutrition |
| spellingShingle | Thilo Samson Chillon Kamil Demircan Raban Arved Heller Ines Maria Hirschbil-Bremer Joachim Diegmann Manuel Bachmann Arash Moghaddam Lutz Schomburg Relationship between Vitamin D Status and Antibody Response to COVID-19 mRNA Vaccination in Healthy Adults Biomedicines vitamins vaccine humoral response SARS-CoV-2 immunology nutrition |
| title | Relationship between Vitamin D Status and Antibody Response to COVID-19 mRNA Vaccination in Healthy Adults |
| title_full | Relationship between Vitamin D Status and Antibody Response to COVID-19 mRNA Vaccination in Healthy Adults |
| title_fullStr | Relationship between Vitamin D Status and Antibody Response to COVID-19 mRNA Vaccination in Healthy Adults |
| title_full_unstemmed | Relationship between Vitamin D Status and Antibody Response to COVID-19 mRNA Vaccination in Healthy Adults |
| title_short | Relationship between Vitamin D Status and Antibody Response to COVID-19 mRNA Vaccination in Healthy Adults |
| title_sort | relationship between vitamin d status and antibody response to covid 19 mrna vaccination in healthy adults |
| topic | vitamins vaccine humoral response SARS-CoV-2 immunology nutrition |
| url | https://www.mdpi.com/2227-9059/9/11/1714 |
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