Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases
Maintenance of protein homeostasis is crucial for virtually every aspect of eukaryotic biology. The ubiquitin-proteasome system (UPS) represents a highly regulated quality control machinery that protects cells from a variety of stress conditions as well as toxic proteins. A large body of evidence ha...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/3/416 |
| _version_ | 1797472582202556416 |
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| author | Stephanie Diaz Kankan Wang Benita Sjögren Xing Liu |
| author_facet | Stephanie Diaz Kankan Wang Benita Sjögren Xing Liu |
| author_sort | Stephanie Diaz |
| collection | DOAJ |
| description | Maintenance of protein homeostasis is crucial for virtually every aspect of eukaryotic biology. The ubiquitin-proteasome system (UPS) represents a highly regulated quality control machinery that protects cells from a variety of stress conditions as well as toxic proteins. A large body of evidence has shown that UPS dysfunction contributes to the pathogenesis of cardiovascular diseases. This review highlights the latest findings regarding the physiological and pathological roles of cullin-RING ubiquitin ligases (CRLs), an essential player in the UPS, in the cardiovascular system. To inspire potential therapeutic invention, factors regulating CRL activities are also discussed. |
| first_indexed | 2024-03-09T20:04:28Z |
| format | Article |
| id | doaj.art-0aec1d031a75415a80e0077a6402750d |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T20:04:28Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-0aec1d031a75415a80e0077a6402750d2023-11-24T00:35:38ZengMDPI AGBiomolecules2218-273X2022-03-0112341610.3390/biom12030416Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular DiseasesStephanie Diaz0Kankan Wang1Benita Sjögren2Xing Liu3Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USADepartment of Biochemistry, Purdue University, West Lafayette, IN 47907, USADepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USADepartment of Biochemistry, Purdue University, West Lafayette, IN 47907, USAMaintenance of protein homeostasis is crucial for virtually every aspect of eukaryotic biology. The ubiquitin-proteasome system (UPS) represents a highly regulated quality control machinery that protects cells from a variety of stress conditions as well as toxic proteins. A large body of evidence has shown that UPS dysfunction contributes to the pathogenesis of cardiovascular diseases. This review highlights the latest findings regarding the physiological and pathological roles of cullin-RING ubiquitin ligases (CRLs), an essential player in the UPS, in the cardiovascular system. To inspire potential therapeutic invention, factors regulating CRL activities are also discussed.https://www.mdpi.com/2218-273X/12/3/416ubiquitin E3 ligasescullin-RING ligasesprotein ubiquitinationprotein degradationcardiovascular disease |
| spellingShingle | Stephanie Diaz Kankan Wang Benita Sjögren Xing Liu Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases Biomolecules ubiquitin E3 ligases cullin-RING ligases protein ubiquitination protein degradation cardiovascular disease |
| title | Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases |
| title_full | Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases |
| title_fullStr | Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases |
| title_full_unstemmed | Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases |
| title_short | Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases |
| title_sort | roles of cullin ring ubiquitin ligases in cardiovascular diseases |
| topic | ubiquitin E3 ligases cullin-RING ligases protein ubiquitination protein degradation cardiovascular disease |
| url | https://www.mdpi.com/2218-273X/12/3/416 |
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