Role of Probiotics and Their Metabolites in Inflammatory Bowel Diseases (IBDs)
Inflammatory Bowel Disease (IBD) is a term used to describe a group of complex disorders of the gastrointestinal (GI) tract. IBDs include two main forms: Crohn’s Disease (CD) and Ulcerative Colitis (UC), which share similar clinical symptoms but differ in the anatomical distribution of the inflammat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Gastroenterology Insights |
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| Online Access: | https://www.mdpi.com/2036-7422/12/1/6 |
| _version_ | 1797415450148077568 |
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| author | Toumi Ryma Arezki Samer Imene Soufli Hayet Rafa Chafia Touil-Boukoffa |
| author_facet | Toumi Ryma Arezki Samer Imene Soufli Hayet Rafa Chafia Touil-Boukoffa |
| author_sort | Toumi Ryma |
| collection | DOAJ |
| description | Inflammatory Bowel Disease (IBD) is a term used to describe a group of complex disorders of the gastrointestinal (GI) tract. IBDs include two main forms: Crohn’s Disease (CD) and Ulcerative Colitis (UC), which share similar clinical symptoms but differ in the anatomical distribution of the inflammatory lesions. The etiology of IBDs is undetermined. Several hypotheses suggest that Crohn’s Disease and Ulcerative Colitis result from an abnormal immune response against endogenous flora and luminal antigens in genetically susceptible individuals. While there is no cure for IBDs, most common treatments (medication and surgery) aim to reduce inflammation and help patients to achieve remission. There is growing evidence and focus on the prophylactic and therapeutic potential of probiotics in IBDs. Probiotics are live microorganisms that regulate the mucosal immune system, the gut microbiota and the production of active metabolites such as Short-Chain Fatty Acids (SCFAs). This review will focus on the role of intestinal dysbiosis in the immunopathogenesis of IBDs and understanding the health-promoting effects of probiotics and their metabolites. |
| first_indexed | 2024-03-09T05:48:46Z |
| format | Article |
| id | doaj.art-0aec4d18d4374afd9e12a7e3472d487b |
| institution | Directory Open Access Journal |
| issn | 2036-7414 2036-7422 |
| language | English |
| last_indexed | 2024-03-09T05:48:46Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gastroenterology Insights |
| spelling | doaj.art-0aec4d18d4374afd9e12a7e3472d487b2023-12-03T12:18:46ZengMDPI AGGastroenterology Insights2036-74142036-74222021-02-01121566610.3390/gastroent12010006Role of Probiotics and Their Metabolites in Inflammatory Bowel Diseases (IBDs)Toumi Ryma0Arezki Samer1Imene Soufli2Hayet Rafa3Chafia Touil-Boukoffa4Laboratory of Cellular and Molecular Biology, University of Sciences and Technology Houari Boumediene (USTHB), Algiers 16111, AlgeriaLaboratory of Cellular and Molecular Biology, University of Sciences and Technology Houari Boumediene (USTHB), Algiers 16111, AlgeriaLaboratory of Cellular and Molecular Biology, University of Sciences and Technology Houari Boumediene (USTHB), Algiers 16111, AlgeriaLaboratory of Cellular and Molecular Biology, University of Sciences and Technology Houari Boumediene (USTHB), Algiers 16111, AlgeriaLaboratory of Cellular and Molecular Biology, University of Sciences and Technology Houari Boumediene (USTHB), Algiers 16111, AlgeriaInflammatory Bowel Disease (IBD) is a term used to describe a group of complex disorders of the gastrointestinal (GI) tract. IBDs include two main forms: Crohn’s Disease (CD) and Ulcerative Colitis (UC), which share similar clinical symptoms but differ in the anatomical distribution of the inflammatory lesions. The etiology of IBDs is undetermined. Several hypotheses suggest that Crohn’s Disease and Ulcerative Colitis result from an abnormal immune response against endogenous flora and luminal antigens in genetically susceptible individuals. While there is no cure for IBDs, most common treatments (medication and surgery) aim to reduce inflammation and help patients to achieve remission. There is growing evidence and focus on the prophylactic and therapeutic potential of probiotics in IBDs. Probiotics are live microorganisms that regulate the mucosal immune system, the gut microbiota and the production of active metabolites such as Short-Chain Fatty Acids (SCFAs). This review will focus on the role of intestinal dysbiosis in the immunopathogenesis of IBDs and understanding the health-promoting effects of probiotics and their metabolites.https://www.mdpi.com/2036-7422/12/1/6Inflammatory Bowel Diseases (IBDs)gut microbiotadysbiosisprobioticsmetabolitesShort-Chain Fatty acids (SCFAs) |
| spellingShingle | Toumi Ryma Arezki Samer Imene Soufli Hayet Rafa Chafia Touil-Boukoffa Role of Probiotics and Their Metabolites in Inflammatory Bowel Diseases (IBDs) Gastroenterology Insights Inflammatory Bowel Diseases (IBDs) gut microbiota dysbiosis probiotics metabolites Short-Chain Fatty acids (SCFAs) |
| title | Role of Probiotics and Their Metabolites in Inflammatory Bowel Diseases (IBDs) |
| title_full | Role of Probiotics and Their Metabolites in Inflammatory Bowel Diseases (IBDs) |
| title_fullStr | Role of Probiotics and Their Metabolites in Inflammatory Bowel Diseases (IBDs) |
| title_full_unstemmed | Role of Probiotics and Their Metabolites in Inflammatory Bowel Diseases (IBDs) |
| title_short | Role of Probiotics and Their Metabolites in Inflammatory Bowel Diseases (IBDs) |
| title_sort | role of probiotics and their metabolites in inflammatory bowel diseases ibds |
| topic | Inflammatory Bowel Diseases (IBDs) gut microbiota dysbiosis probiotics metabolites Short-Chain Fatty acids (SCFAs) |
| url | https://www.mdpi.com/2036-7422/12/1/6 |
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