Variety of effects of silicon dioxide colloid in the treatment of antibiotic-associated diarrhea in children
Antibiotic-associated diarrhea (AAD) is a key aspect of pediatrics concerning antibiotic therapy Purpose. The article aims at investigating the effects of colloidal silicon dioxide in the treatment of antibiotic-associated diarrhea in children. Materials and methods. Using parametric and nonparametr...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Ltd. “The National Academy of Pediatric Science and Innovation”
2022-04-01
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| Series: | Rossijskij Vestnik Perinatologii i Pediatrii |
| Subjects: | |
| Online Access: | https://www.ped-perinatology.ru/jour/article/view/1582 |
| _version_ | 1797875079012417536 |
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| author | A. M. Zakirova R. A. Faizullina T. B. Moroz D. T. Shayapova A. G. Kadriev E. L. Rashitova A. I. Klyushkina A. A. Kadriev N. M. Gilfanov |
| author_facet | A. M. Zakirova R. A. Faizullina T. B. Moroz D. T. Shayapova A. G. Kadriev E. L. Rashitova A. I. Klyushkina A. A. Kadriev N. M. Gilfanov |
| author_sort | A. M. Zakirova |
| collection | DOAJ |
| description | Antibiotic-associated diarrhea (AAD) is a key aspect of pediatrics concerning antibiotic therapy Purpose. The article aims at investigating the effects of colloidal silicon dioxide in the treatment of antibiotic-associated diarrhea in children. Materials and methods. Using parametric and nonparametric methods of analysis, 83 patients were examined (treatment group — 41 children who used colloidal silicon dioxide and the control group — 42 children) of both sexes (mean age (13.7 ± 2.6) years) with pathology of the lower respiratory tract (acute bronchitis or community-acquired pneumonia), who developed AAD against the background of ABT. Results. When using colloidal silicon dioxide in 75.6% of children, diarrhea decreased by the 2nd day and stopped by the 4th day (median — 0 points). Against the background of taking the drug throughout the treatment, there was a marked 3-fold decrease in all AAD values. The assessment of the efficacy and safety of the drug according to the data of medical researchers was 3.4 points. Analysis of subjective data on the tolerability of the drug showed «excellent» and «good». Against the background of the full course of treatment with colloidal silicon dioxide, a 2 times more pronounced decrease in the characteristics of AAD was noted. Conclusion. The presented data are intended to focus the attention of pediatricians on the rational use of ABT, timely diagnosis of an unwanted drug reaction in the form of AAD and its correction. The studied drug showed high efficacy and safety, which makes it possible to recommend it as a symptomatic treatment of diarrhea that developed against the background of ABT treatment in the complex therapy of diseases of the lower respiratory tract in children. |
| first_indexed | 2024-04-10T01:40:57Z |
| format | Article |
| id | doaj.art-0aecd8ded56a4c6ba7a5fc49f7d1642b |
| institution | Directory Open Access Journal |
| issn | 1027-4065 2500-2228 |
| language | Russian |
| last_indexed | 2024-04-10T01:40:57Z |
| publishDate | 2022-04-01 |
| publisher | Ltd. “The National Academy of Pediatric Science and Innovation” |
| record_format | Article |
| series | Rossijskij Vestnik Perinatologii i Pediatrii |
| spelling | doaj.art-0aecd8ded56a4c6ba7a5fc49f7d1642b2023-03-13T09:12:52ZrusLtd. “The National Academy of Pediatric Science and Innovation”Rossijskij Vestnik Perinatologii i Pediatrii1027-40652500-22282022-04-01671768110.21508/1027-4065-2022-67-1-76-811159Variety of effects of silicon dioxide colloid in the treatment of antibiotic-associated diarrhea in childrenA. M. Zakirova0R. A. Faizullina1T. B. Moroz2D. T. Shayapova3A. G. Kadriev4E. L. Rashitova5A. I. Klyushkina6A. A. Kadriev7N. M. Gilfanov8ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава РоссииФГБОУ ВО «Казанский государственный медицинский университет» Минздрава РоссииГАУЗ «Центральная городская клиническая больница №18»ГАУЗ «Центральная городская клиническая больница №18»ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава РоссииФГБОУ ВО «Казанский государственный медицинский университет» Минздрава РоссииФГБОУ ВО «Казанский государственный медицинский университет» Минздрава РоссииФГБОУ ВО «Казанский государственный медицинский университет» Минздрава РоссииФГБОУ ВО «Казанский государственный медицинский университет» Минздрава РоссииAntibiotic-associated diarrhea (AAD) is a key aspect of pediatrics concerning antibiotic therapy Purpose. The article aims at investigating the effects of colloidal silicon dioxide in the treatment of antibiotic-associated diarrhea in children. Materials and methods. Using parametric and nonparametric methods of analysis, 83 patients were examined (treatment group — 41 children who used colloidal silicon dioxide and the control group — 42 children) of both sexes (mean age (13.7 ± 2.6) years) with pathology of the lower respiratory tract (acute bronchitis or community-acquired pneumonia), who developed AAD against the background of ABT. Results. When using colloidal silicon dioxide in 75.6% of children, diarrhea decreased by the 2nd day and stopped by the 4th day (median — 0 points). Against the background of taking the drug throughout the treatment, there was a marked 3-fold decrease in all AAD values. The assessment of the efficacy and safety of the drug according to the data of medical researchers was 3.4 points. Analysis of subjective data on the tolerability of the drug showed «excellent» and «good». Against the background of the full course of treatment with colloidal silicon dioxide, a 2 times more pronounced decrease in the characteristics of AAD was noted. Conclusion. The presented data are intended to focus the attention of pediatricians on the rational use of ABT, timely diagnosis of an unwanted drug reaction in the form of AAD and its correction. The studied drug showed high efficacy and safety, which makes it possible to recommend it as a symptomatic treatment of diarrhea that developed against the background of ABT treatment in the complex therapy of diseases of the lower respiratory tract in children.https://www.ped-perinatology.ru/jour/article/view/1582детидиареяэнтеросорбенткремния диоксид коллоидный |
| spellingShingle | A. M. Zakirova R. A. Faizullina T. B. Moroz D. T. Shayapova A. G. Kadriev E. L. Rashitova A. I. Klyushkina A. A. Kadriev N. M. Gilfanov Variety of effects of silicon dioxide colloid in the treatment of antibiotic-associated diarrhea in children Rossijskij Vestnik Perinatologii i Pediatrii дети диарея энтеросорбент кремния диоксид коллоидный |
| title | Variety of effects of silicon dioxide colloid in the treatment of antibiotic-associated diarrhea in children |
| title_full | Variety of effects of silicon dioxide colloid in the treatment of antibiotic-associated diarrhea in children |
| title_fullStr | Variety of effects of silicon dioxide colloid in the treatment of antibiotic-associated diarrhea in children |
| title_full_unstemmed | Variety of effects of silicon dioxide colloid in the treatment of antibiotic-associated diarrhea in children |
| title_short | Variety of effects of silicon dioxide colloid in the treatment of antibiotic-associated diarrhea in children |
| title_sort | variety of effects of silicon dioxide colloid in the treatment of antibiotic associated diarrhea in children |
| topic | дети диарея энтеросорбент кремния диоксид коллоидный |
| url | https://www.ped-perinatology.ru/jour/article/view/1582 |
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