The trace that is valuable: serum copper and copper to zinc ratio for survival prediction in younger patients with newly diagnosed acute myeloid leukaemia
Abstract Purpose No data on predicting the survival of AML patients based on the level of trace elements in the serum have been presented to date. The aims of this prospective cohort study were as follows: (i) to evaluate the serum Cu and Zn levels in people from Northeast China, (ii) to assess the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-022-10486-7 |
| _version_ | 1797958618383908864 |
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| author | Taotao Li Liming Shi Wei Wei Jiancheng Xu Qiuju Liu |
| author_facet | Taotao Li Liming Shi Wei Wei Jiancheng Xu Qiuju Liu |
| author_sort | Taotao Li |
| collection | DOAJ |
| description | Abstract Purpose No data on predicting the survival of AML patients based on the level of trace elements in the serum have been presented to date. The aims of this prospective cohort study were as follows: (i) to evaluate the serum Cu and Zn levels in people from Northeast China, (ii) to assess the association between the serum Cu level (SCL) and Cu to Zn ratio (SCZR) and clinical and nutrition data, and (iii) to investigate the predictive values of the SCL and SCZR in newly diagnosed de novo AML patients. Methods A total of 105 newly diagnosed AML patients and 82 healthy controls were recruited. The serum Cu and Zn levels were determined by inductively coupled plasma spectrometry. The associations of SCL and SCZR with the survival of these AML patients were assessed by Cox proportional hazards models. Results Both SCL and SCZR were positively related to the blast percentage of bone marrow and C-reactive protein, negatively related to albumin level and CEBPA double mutation and were significantly associated with worse overall survival and disease-free survival. Meanwhile, patients with higher SCL had worse CTCAE levels, and patients with higher SCZR showed less complete remission during the first course of induction chemotherapy. Moreover, higher SCZR was positively associated with ELN risk stratification, and was negatively associated with haemoglobin level and prognostic nutritional index (PNI). Conclusion The SCL and SCZR are associated with long-term survival in patients with newly diagnosed AML undergoing intensive induction and may serve as important predictive biomarkers. |
| first_indexed | 2024-04-11T00:21:29Z |
| format | Article |
| id | doaj.art-0aede61dc7914a7f8718e21278e52c1f |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-11T00:21:29Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-0aede61dc7914a7f8718e21278e52c1f2023-01-08T12:14:31ZengBMCBMC Cancer1471-24072023-01-0123111110.1186/s12885-022-10486-7The trace that is valuable: serum copper and copper to zinc ratio for survival prediction in younger patients with newly diagnosed acute myeloid leukaemiaTaotao Li0Liming Shi1Wei Wei2Jiancheng Xu3Qiuju Liu4Department of Haematology, the First Hospital of Jilin UniversityDepartment of Haematology, the First Hospital of Jilin UniversityDepartment of Haematology, Zhongda Hospital, Medical School of Southeast UniversityDepartment of Laboratory Medicine, First Hospital of Jilin UniversityDepartment of Haematology, the First Hospital of Jilin UniversityAbstract Purpose No data on predicting the survival of AML patients based on the level of trace elements in the serum have been presented to date. The aims of this prospective cohort study were as follows: (i) to evaluate the serum Cu and Zn levels in people from Northeast China, (ii) to assess the association between the serum Cu level (SCL) and Cu to Zn ratio (SCZR) and clinical and nutrition data, and (iii) to investigate the predictive values of the SCL and SCZR in newly diagnosed de novo AML patients. Methods A total of 105 newly diagnosed AML patients and 82 healthy controls were recruited. The serum Cu and Zn levels were determined by inductively coupled plasma spectrometry. The associations of SCL and SCZR with the survival of these AML patients were assessed by Cox proportional hazards models. Results Both SCL and SCZR were positively related to the blast percentage of bone marrow and C-reactive protein, negatively related to albumin level and CEBPA double mutation and were significantly associated with worse overall survival and disease-free survival. Meanwhile, patients with higher SCL had worse CTCAE levels, and patients with higher SCZR showed less complete remission during the first course of induction chemotherapy. Moreover, higher SCZR was positively associated with ELN risk stratification, and was negatively associated with haemoglobin level and prognostic nutritional index (PNI). Conclusion The SCL and SCZR are associated with long-term survival in patients with newly diagnosed AML undergoing intensive induction and may serve as important predictive biomarkers.https://doi.org/10.1186/s12885-022-10486-7Acute myeloid leukaemiaCopperZincLong-term survival |
| spellingShingle | Taotao Li Liming Shi Wei Wei Jiancheng Xu Qiuju Liu The trace that is valuable: serum copper and copper to zinc ratio for survival prediction in younger patients with newly diagnosed acute myeloid leukaemia BMC Cancer Acute myeloid leukaemia Copper Zinc Long-term survival |
| title | The trace that is valuable: serum copper and copper to zinc ratio for survival prediction in younger patients with newly diagnosed acute myeloid leukaemia |
| title_full | The trace that is valuable: serum copper and copper to zinc ratio for survival prediction in younger patients with newly diagnosed acute myeloid leukaemia |
| title_fullStr | The trace that is valuable: serum copper and copper to zinc ratio for survival prediction in younger patients with newly diagnosed acute myeloid leukaemia |
| title_full_unstemmed | The trace that is valuable: serum copper and copper to zinc ratio for survival prediction in younger patients with newly diagnosed acute myeloid leukaemia |
| title_short | The trace that is valuable: serum copper and copper to zinc ratio for survival prediction in younger patients with newly diagnosed acute myeloid leukaemia |
| title_sort | trace that is valuable serum copper and copper to zinc ratio for survival prediction in younger patients with newly diagnosed acute myeloid leukaemia |
| topic | Acute myeloid leukaemia Copper Zinc Long-term survival |
| url | https://doi.org/10.1186/s12885-022-10486-7 |
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