Metabolic Pathways as a Novel Landscape in Pancreatic Ductal Adenocarcinoma
Metabolism plays a fundamental role in both human physiology and pathology, including pancreatic ductal adenocarcinoma (PDAC) and other tumors. Anabolic and catabolic processes do not only have energetic implications but are tightly associated with other cellular activities, such as DNA duplication,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/15/3799 |
| _version_ | 1797432949988130816 |
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| author | Ahmad Ali Ugo Chianese Chiara Papulino Antonella Toraldo Mawada Elmagboul Abdalla Abakar Eugenia Passaro Rosario Cennamo Nunzio Del Gaudio Lucia Altucci Rosaria Benedetti |
| author_facet | Ahmad Ali Ugo Chianese Chiara Papulino Antonella Toraldo Mawada Elmagboul Abdalla Abakar Eugenia Passaro Rosario Cennamo Nunzio Del Gaudio Lucia Altucci Rosaria Benedetti |
| author_sort | Ahmad Ali |
| collection | DOAJ |
| description | Metabolism plays a fundamental role in both human physiology and pathology, including pancreatic ductal adenocarcinoma (PDAC) and other tumors. Anabolic and catabolic processes do not only have energetic implications but are tightly associated with other cellular activities, such as DNA duplication, redox reactions, and cell homeostasis. PDAC displays a marked metabolic phenotype and the observed reduction in tumor growth induced by calorie restriction with in vivo models supports the crucial role of metabolism in this cancer type. The aggressiveness of PDAC might, therefore, be reduced by interventions on bioenergetic circuits. In this review, we describe the main metabolic mechanisms involved in PDAC growth and the biological features that may favor its onset and progression within an immunometabolic context. We also discuss the need to bridge the gap between basic research and clinical practice in order to offer alternative therapeutic approaches for PDAC patients in the more immediate future. |
| first_indexed | 2024-03-09T10:09:07Z |
| format | Article |
| id | doaj.art-0aef8974f89849c39ca4c0d20debf8bc |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T10:09:07Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-0aef8974f89849c39ca4c0d20debf8bc2023-12-01T22:52:21ZengMDPI AGCancers2072-66942022-08-011415379910.3390/cancers14153799Metabolic Pathways as a Novel Landscape in Pancreatic Ductal AdenocarcinomaAhmad Ali0Ugo Chianese1Chiara Papulino2Antonella Toraldo3Mawada Elmagboul Abdalla Abakar4Eugenia Passaro5Rosario Cennamo6Nunzio Del Gaudio7Lucia Altucci8Rosaria Benedetti9Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyMetabolism plays a fundamental role in both human physiology and pathology, including pancreatic ductal adenocarcinoma (PDAC) and other tumors. Anabolic and catabolic processes do not only have energetic implications but are tightly associated with other cellular activities, such as DNA duplication, redox reactions, and cell homeostasis. PDAC displays a marked metabolic phenotype and the observed reduction in tumor growth induced by calorie restriction with in vivo models supports the crucial role of metabolism in this cancer type. The aggressiveness of PDAC might, therefore, be reduced by interventions on bioenergetic circuits. In this review, we describe the main metabolic mechanisms involved in PDAC growth and the biological features that may favor its onset and progression within an immunometabolic context. We also discuss the need to bridge the gap between basic research and clinical practice in order to offer alternative therapeutic approaches for PDAC patients in the more immediate future.https://www.mdpi.com/2072-6694/14/15/3799PDACmetabolismglucoseamino acidslipidsimmune response |
| spellingShingle | Ahmad Ali Ugo Chianese Chiara Papulino Antonella Toraldo Mawada Elmagboul Abdalla Abakar Eugenia Passaro Rosario Cennamo Nunzio Del Gaudio Lucia Altucci Rosaria Benedetti Metabolic Pathways as a Novel Landscape in Pancreatic Ductal Adenocarcinoma Cancers PDAC metabolism glucose amino acids lipids immune response |
| title | Metabolic Pathways as a Novel Landscape in Pancreatic Ductal Adenocarcinoma |
| title_full | Metabolic Pathways as a Novel Landscape in Pancreatic Ductal Adenocarcinoma |
| title_fullStr | Metabolic Pathways as a Novel Landscape in Pancreatic Ductal Adenocarcinoma |
| title_full_unstemmed | Metabolic Pathways as a Novel Landscape in Pancreatic Ductal Adenocarcinoma |
| title_short | Metabolic Pathways as a Novel Landscape in Pancreatic Ductal Adenocarcinoma |
| title_sort | metabolic pathways as a novel landscape in pancreatic ductal adenocarcinoma |
| topic | PDAC metabolism glucose amino acids lipids immune response |
| url | https://www.mdpi.com/2072-6694/14/15/3799 |
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