Accurate external localization of the left frontal cortex in dogs by using pointer based frameless neuronavigation
Background In humans, non-stereotactic frameless neuronavigation systems are used as a topographical tool for non-invasive brain stimulation methods such as Transcranial Magnetic Stimulation (TMS). TMS studies in dogs may provide treatment modalities for several neuropsychological disorders in dogs....
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2017-07-01
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| Online Access: | https://peerj.com/articles/3425.pdf |
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| author | Robrecht Dockx Kathelijne Peremans Romain Duprat Lise Vlerick Nick Van Laeken Jimmy H. Saunders Ingeborgh Polis Filip De Vos Chris Baeken |
| author_facet | Robrecht Dockx Kathelijne Peremans Romain Duprat Lise Vlerick Nick Van Laeken Jimmy H. Saunders Ingeborgh Polis Filip De Vos Chris Baeken |
| author_sort | Robrecht Dockx |
| collection | DOAJ |
| description | Background In humans, non-stereotactic frameless neuronavigation systems are used as a topographical tool for non-invasive brain stimulation methods such as Transcranial Magnetic Stimulation (TMS). TMS studies in dogs may provide treatment modalities for several neuropsychological disorders in dogs. Nevertheless, an accurate non-invasive localization of a stimulation target has not yet been performed in this species. Hypothesis This study was primarily put forward to externally locate the left frontal cortex in 18 healthy dogs by means of a human non-stereotactic neuronavigation system. Secondly, the accuracy of the external localization was assessed. Animals A total of 18 healthy dogs, drawn at random from the research colony present at the faculty of Veterinary Medicine (Ghent University), were used. Methods Two sets of coordinates (X, Y, Z and X″, Y″, Z″) were compared on each dog their tomographical dataset. Results The non-stereotactic neuronavigation system was able to externally locate the frontal cortex in dogs with accuracy comparable with human studies. Conclusion and clinical importance This result indicates that a non-stereotactic neuronavigation system can accurately externally locate the left frontal cortex and paves the way to use guided non-invasive brain stimulation methods as an alternative treatment procedure for neurological and behavioral disorders in dogs. This technique could, in analogy with human guided non-invasive brain stimulation, provide a better treatment outcome for dogs suffering from anxiety disorders when compared to its non-guided alternative. |
| first_indexed | 2024-03-09T06:44:57Z |
| format | Article |
| id | doaj.art-0af09657d1c14d60a122553bc26faf73 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:44:57Z |
| publishDate | 2017-07-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-0af09657d1c14d60a122553bc26faf732023-12-03T10:37:10ZengPeerJ Inc.PeerJ2167-83592017-07-015e342510.7717/peerj.3425Accurate external localization of the left frontal cortex in dogs by using pointer based frameless neuronavigationRobrecht Dockx0Kathelijne Peremans1Romain Duprat2Lise Vlerick3Nick Van Laeken4Jimmy H. Saunders5Ingeborgh Polis6Filip De Vos7Chris Baeken8Department of Psychiatry and Medical Psychology, Ghent University, Ghent, East-Flanders, BelgiumFaculty of Veterinary Medicine, Ghent University, Merelbeke, East-Flanders, BelgiumDepartment of Psychiatry and Medical Psychology, Ghent University, Ghent, East-Flanders, BelgiumFaculty of Veterinary Medicine, Ghent University, Merelbeke, East-Flanders, BelgiumFaculty of Pharmaceutical Sciences, Ghent University, Ghent, East-Flanders, BelgiumFaculty of Veterinary Medicine, Ghent University, Merelbeke, East-Flanders, BelgiumFaculty of Veterinary Medicine, Ghent University, Merelbeke, East-Flanders, BelgiumFaculty of Pharmaceutical Sciences, Ghent University, Ghent, East-Flanders, BelgiumDepartment of Psychiatry and Medical Psychology, Ghent University, Ghent, East-Flanders, BelgiumBackground In humans, non-stereotactic frameless neuronavigation systems are used as a topographical tool for non-invasive brain stimulation methods such as Transcranial Magnetic Stimulation (TMS). TMS studies in dogs may provide treatment modalities for several neuropsychological disorders in dogs. Nevertheless, an accurate non-invasive localization of a stimulation target has not yet been performed in this species. Hypothesis This study was primarily put forward to externally locate the left frontal cortex in 18 healthy dogs by means of a human non-stereotactic neuronavigation system. Secondly, the accuracy of the external localization was assessed. Animals A total of 18 healthy dogs, drawn at random from the research colony present at the faculty of Veterinary Medicine (Ghent University), were used. Methods Two sets of coordinates (X, Y, Z and X″, Y″, Z″) were compared on each dog their tomographical dataset. Results The non-stereotactic neuronavigation system was able to externally locate the frontal cortex in dogs with accuracy comparable with human studies. Conclusion and clinical importance This result indicates that a non-stereotactic neuronavigation system can accurately externally locate the left frontal cortex and paves the way to use guided non-invasive brain stimulation methods as an alternative treatment procedure for neurological and behavioral disorders in dogs. This technique could, in analogy with human guided non-invasive brain stimulation, provide a better treatment outcome for dogs suffering from anxiety disorders when compared to its non-guided alternative.https://peerj.com/articles/3425.pdfCanineNon-stereotacticBrainNeuronavigationTMSNeuropsychiatric disorders |
| spellingShingle | Robrecht Dockx Kathelijne Peremans Romain Duprat Lise Vlerick Nick Van Laeken Jimmy H. Saunders Ingeborgh Polis Filip De Vos Chris Baeken Accurate external localization of the left frontal cortex in dogs by using pointer based frameless neuronavigation PeerJ Canine Non-stereotactic Brain Neuronavigation TMS Neuropsychiatric disorders |
| title | Accurate external localization of the left frontal cortex in dogs by using pointer based frameless neuronavigation |
| title_full | Accurate external localization of the left frontal cortex in dogs by using pointer based frameless neuronavigation |
| title_fullStr | Accurate external localization of the left frontal cortex in dogs by using pointer based frameless neuronavigation |
| title_full_unstemmed | Accurate external localization of the left frontal cortex in dogs by using pointer based frameless neuronavigation |
| title_short | Accurate external localization of the left frontal cortex in dogs by using pointer based frameless neuronavigation |
| title_sort | accurate external localization of the left frontal cortex in dogs by using pointer based frameless neuronavigation |
| topic | Canine Non-stereotactic Brain Neuronavigation TMS Neuropsychiatric disorders |
| url | https://peerj.com/articles/3425.pdf |
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