Association between breastfeeding, host genetic factors, and calicivirus gastroenteritis in a Nicaraguan birth cohort
<h4>Background</h4> Norovirus and sapovirus are important causes of childhood acute gastroenteritis (AGE). Breastfeeding prevents AGE generally; however, it is unknown if breastfeeding prevents AGE caused specifically by norovirus and sapovirus. <h4>Methods</h4> We investigat...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565698/?tool=EBI |
| _version_ | 1828342549977235456 |
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| author | Nadja Alexandra Vielot Ruthly François Emilya Huseynova Fredman González Yaoska Reyes Lester Gutierrez Johan Nordgren Christian Toval-Ruiz Samuel Vilchez Jan Vinjé Sylvia Becker-Dreps Filemon Bucardo |
| author_facet | Nadja Alexandra Vielot Ruthly François Emilya Huseynova Fredman González Yaoska Reyes Lester Gutierrez Johan Nordgren Christian Toval-Ruiz Samuel Vilchez Jan Vinjé Sylvia Becker-Dreps Filemon Bucardo |
| author_sort | Nadja Alexandra Vielot |
| collection | DOAJ |
| description | <h4>Background</h4> Norovirus and sapovirus are important causes of childhood acute gastroenteritis (AGE). Breastfeeding prevents AGE generally; however, it is unknown if breastfeeding prevents AGE caused specifically by norovirus and sapovirus. <h4>Methods</h4> We investigated the association between breastfeeding and norovirus or sapovirus AGE episodes in a birth cohort. Weekly data on breastfeeding and AGE episodes were captured during the first year of life. Stools were collected from children with AGE and tested by RT-qPCR for norovirus and sapovirus. Time-dependent Cox models estimated associations between weekly breastfeeding and time to first norovirus or sapovirus AGE. <h4>Findings</h4> From June 2017 to July 2018, 444 newborns were enrolled in the study. In the first year of life, 69 and 34 children experienced a norovirus and a sapovirus episode, respectively. Exclusive breastfeeding lasted a median of 2 weeks, and any breastfeeding lasted a median of 43 weeks. Breastfeeding in the last week did not prevent norovirus (HR: 1.09, 95% CI: 0.62, 1.92) or sapovirus (HR: 1.00, 95% CI: 0.82, 1.21) AGE in a given week, adjusting for household sanitation, consumption of high-risk foods, and mother’s and child’s histo-blood group phenotypes. Maternal secretor-positive phenotype was protective against norovirus AGE, whereas child’s secretor-positive phenotype was a risk factor for norovirus AGE. <h4>Interpretation</h4> Exclusive breastfeeding in this population was short-lived, and no conclusions could be drawn about its potential to prevent norovirus or sapovirus AGE. Non-exclusive breastfeeding did not prevent norovirus or sapovirus AGE in the first year of life. However, maternal secretor-positive phenotype was associated with a reduced hazard of norovirus AGE. |
| first_indexed | 2024-04-13T23:31:15Z |
| format | Article |
| id | doaj.art-0af0be61a4224795a105d78c3c49eeb6 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T23:31:15Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0af0be61a4224795a105d78c3c49eeb62022-12-22T02:24:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-011710Association between breastfeeding, host genetic factors, and calicivirus gastroenteritis in a Nicaraguan birth cohortNadja Alexandra VielotRuthly FrançoisEmilya HuseynovaFredman GonzálezYaoska ReyesLester GutierrezJohan NordgrenChristian Toval-RuizSamuel VilchezJan VinjéSylvia Becker-DrepsFilemon Bucardo<h4>Background</h4> Norovirus and sapovirus are important causes of childhood acute gastroenteritis (AGE). Breastfeeding prevents AGE generally; however, it is unknown if breastfeeding prevents AGE caused specifically by norovirus and sapovirus. <h4>Methods</h4> We investigated the association between breastfeeding and norovirus or sapovirus AGE episodes in a birth cohort. Weekly data on breastfeeding and AGE episodes were captured during the first year of life. Stools were collected from children with AGE and tested by RT-qPCR for norovirus and sapovirus. Time-dependent Cox models estimated associations between weekly breastfeeding and time to first norovirus or sapovirus AGE. <h4>Findings</h4> From June 2017 to July 2018, 444 newborns were enrolled in the study. In the first year of life, 69 and 34 children experienced a norovirus and a sapovirus episode, respectively. Exclusive breastfeeding lasted a median of 2 weeks, and any breastfeeding lasted a median of 43 weeks. Breastfeeding in the last week did not prevent norovirus (HR: 1.09, 95% CI: 0.62, 1.92) or sapovirus (HR: 1.00, 95% CI: 0.82, 1.21) AGE in a given week, adjusting for household sanitation, consumption of high-risk foods, and mother’s and child’s histo-blood group phenotypes. Maternal secretor-positive phenotype was protective against norovirus AGE, whereas child’s secretor-positive phenotype was a risk factor for norovirus AGE. <h4>Interpretation</h4> Exclusive breastfeeding in this population was short-lived, and no conclusions could be drawn about its potential to prevent norovirus or sapovirus AGE. Non-exclusive breastfeeding did not prevent norovirus or sapovirus AGE in the first year of life. However, maternal secretor-positive phenotype was associated with a reduced hazard of norovirus AGE.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565698/?tool=EBI |
| spellingShingle | Nadja Alexandra Vielot Ruthly François Emilya Huseynova Fredman González Yaoska Reyes Lester Gutierrez Johan Nordgren Christian Toval-Ruiz Samuel Vilchez Jan Vinjé Sylvia Becker-Dreps Filemon Bucardo Association between breastfeeding, host genetic factors, and calicivirus gastroenteritis in a Nicaraguan birth cohort PLoS ONE |
| title | Association between breastfeeding, host genetic factors, and calicivirus gastroenteritis in a Nicaraguan birth cohort |
| title_full | Association between breastfeeding, host genetic factors, and calicivirus gastroenteritis in a Nicaraguan birth cohort |
| title_fullStr | Association between breastfeeding, host genetic factors, and calicivirus gastroenteritis in a Nicaraguan birth cohort |
| title_full_unstemmed | Association between breastfeeding, host genetic factors, and calicivirus gastroenteritis in a Nicaraguan birth cohort |
| title_short | Association between breastfeeding, host genetic factors, and calicivirus gastroenteritis in a Nicaraguan birth cohort |
| title_sort | association between breastfeeding host genetic factors and calicivirus gastroenteritis in a nicaraguan birth cohort |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9565698/?tool=EBI |
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