Indomethacin Enhances Type 1 Cannabinoid Receptor Signaling

Indomethacin Enhances Type 1 Cannabinoid Receptor Signaling

In addition to its known actions as a non-selective cyclooxygenase (COX) 1 and 2 inhibitor, we hypothesized that indomethacin can act as an allosteric modulator of the type 1 cannabinoid receptor (CB1R) because of its shared structural features with the known allosteric modulators of CB1R. Indometha...

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Bibliographic Details
Main Authors: Robert B. Laprairie, Kawthar A. Mohamed, Ayat Zagzoog, Melanie E. M. Kelly, Lesley A. Stevenson, Roger Pertwee, Eileen M. Denovan-Wright, Ganesh A. Thakur
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
cannabinoid
indomethacin
cannabinoid receptor
allosteric modulator
molecular pharmacology
cell signaling
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00257/full

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