Treatment of Chronic Migraine with Focus on Botulinum Neurotoxins
Migraine is the most common neurological disorder, and contributes to disability and large healthcare costs in the United States and the world. The treatment of migraine until recently has focused on medications, both abortive and prophylactic, but treatment of chronic migraine has been revolutioniz...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-07-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6651/7/7/2615 |
| _version_ | 1828109676513853440 |
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| author | Sara M. Schaefer Christopher H. Gottschalk Bahman Jabbari |
| author_facet | Sara M. Schaefer Christopher H. Gottschalk Bahman Jabbari |
| author_sort | Sara M. Schaefer |
| collection | DOAJ |
| description | Migraine is the most common neurological disorder, and contributes to disability and large healthcare costs in the United States and the world. The treatment of migraine until recently has focused on medications, both abortive and prophylactic, but treatment of chronic migraine has been revolutionized with the introduction of botulinum toxin injection therapy. In this review, we explore the current understanding of migraine pathophysiology, and the evolution of the use of botulinum toxin therapy including proposed pathophysiological mechanisms through animal data. We also discuss the similarities and differences between three injection techniques. |
| first_indexed | 2024-04-11T11:06:58Z |
| format | Article |
| id | doaj.art-0af58e94eaeb4a148fcfb1b7fc20e463 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-11T11:06:58Z |
| publishDate | 2015-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-0af58e94eaeb4a148fcfb1b7fc20e4632022-12-22T04:28:16ZengMDPI AGToxins2072-66512015-07-01772615262810.3390/toxins7072615toxins7072615Treatment of Chronic Migraine with Focus on Botulinum NeurotoxinsSara M. Schaefer0Christopher H. Gottschalk1Bahman Jabbari2Department of Neurology, Yale University, 20 York St., New Haven, CT 06510, USADepartment of Neurology, Yale University, 20 York St., New Haven, CT 06510, USADepartment of Neurology, Yale University, 20 York St., New Haven, CT 06510, USAMigraine is the most common neurological disorder, and contributes to disability and large healthcare costs in the United States and the world. The treatment of migraine until recently has focused on medications, both abortive and prophylactic, but treatment of chronic migraine has been revolutionized with the introduction of botulinum toxin injection therapy. In this review, we explore the current understanding of migraine pathophysiology, and the evolution of the use of botulinum toxin therapy including proposed pathophysiological mechanisms through animal data. We also discuss the similarities and differences between three injection techniques.http://www.mdpi.com/2072-6651/7/7/2615botulinum toxinmigraineheadachechronic migrainechronic daily headacheneurotoxinsmedication overuse headache |
| spellingShingle | Sara M. Schaefer Christopher H. Gottschalk Bahman Jabbari Treatment of Chronic Migraine with Focus on Botulinum Neurotoxins Toxins botulinum toxin migraine headache chronic migraine chronic daily headache neurotoxins medication overuse headache |
| title | Treatment of Chronic Migraine with Focus on Botulinum Neurotoxins |
| title_full | Treatment of Chronic Migraine with Focus on Botulinum Neurotoxins |
| title_fullStr | Treatment of Chronic Migraine with Focus on Botulinum Neurotoxins |
| title_full_unstemmed | Treatment of Chronic Migraine with Focus on Botulinum Neurotoxins |
| title_short | Treatment of Chronic Migraine with Focus on Botulinum Neurotoxins |
| title_sort | treatment of chronic migraine with focus on botulinum neurotoxins |
| topic | botulinum toxin migraine headache chronic migraine chronic daily headache neurotoxins medication overuse headache |
| url | http://www.mdpi.com/2072-6651/7/7/2615 |
| work_keys_str_mv | AT saramschaefer treatmentofchronicmigrainewithfocusonbotulinumneurotoxins AT christopherhgottschalk treatmentofchronicmigrainewithfocusonbotulinumneurotoxins AT bahmanjabbari treatmentofchronicmigrainewithfocusonbotulinumneurotoxins |