Targeted therapy combined with immunotherapy in patients with breast infiltrating ductal carcinoma with axillary lymph node metastasis of metaplastic SCC
Abstract At present, the clinicopathological features, optimal treatment patterns, and prognosis of breast metaplastic squamous cell carcinoma (SCC) are not fully understood and are still controversial. Here, we report a 56‐year‐old female patient with breast infiltrating ductal carcinoma with axill...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-10-01
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| Series: | Thoracic Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1759-7714.14602 |
| _version_ | 1811205084945580032 |
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| author | Rilan Bai Lin Jia Yangyang Gao Xu Sun Naifei Chen Zheng Lv Jiuwei Cui |
| author_facet | Rilan Bai Lin Jia Yangyang Gao Xu Sun Naifei Chen Zheng Lv Jiuwei Cui |
| author_sort | Rilan Bai |
| collection | DOAJ |
| description | Abstract At present, the clinicopathological features, optimal treatment patterns, and prognosis of breast metaplastic squamous cell carcinoma (SCC) are not fully understood and are still controversial. Here, we report a 56‐year‐old female patient with breast infiltrating ductal carcinoma with axillary lymph node metastasis of metaplastic SCC admitted to our hospital. Their homology was clarified by comparing the gene mutation results of the two lesions, that is, the axillary lymph node lesion was a metastasis of breast metaplastic SCC. We treated the patient with Poly ADP‐ribose Polymerase (PARP) inhibitors in combination with immune checkpoint inhibitors (ICIs) and found that she could achieve clinical benefit from the combination regimen. We reported a successful diagnosis and treatment of this rare refractory disease and reviewed the literature on the characteristics, pathogenesis, and advances in the diagnosis and treatment of breast metaplastic SCC. |
| first_indexed | 2024-04-12T03:24:41Z |
| format | Article |
| id | doaj.art-0af5bedc40fd415b9cd66a76bf7ab3d5 |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-04-12T03:24:41Z |
| publishDate | 2022-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-0af5bedc40fd415b9cd66a76bf7ab3d52022-12-22T03:49:44ZengWileyThoracic Cancer1759-77061759-77142022-10-0113192799280710.1111/1759-7714.14602Targeted therapy combined with immunotherapy in patients with breast infiltrating ductal carcinoma with axillary lymph node metastasis of metaplastic SCCRilan Bai0Lin Jia1Yangyang Gao2Xu Sun3Naifei Chen4Zheng Lv5Jiuwei Cui6Cancer Center The First Hospital of Jilin University Changchun ChinaCancer Center The First Hospital of Jilin University Changchun ChinaCancer Center The First Hospital of Jilin University Changchun ChinaCancer Center The First Hospital of Jilin University Changchun ChinaCancer Center The First Hospital of Jilin University Changchun ChinaCancer Center The First Hospital of Jilin University Changchun ChinaCancer Center The First Hospital of Jilin University Changchun ChinaAbstract At present, the clinicopathological features, optimal treatment patterns, and prognosis of breast metaplastic squamous cell carcinoma (SCC) are not fully understood and are still controversial. Here, we report a 56‐year‐old female patient with breast infiltrating ductal carcinoma with axillary lymph node metastasis of metaplastic SCC admitted to our hospital. Their homology was clarified by comparing the gene mutation results of the two lesions, that is, the axillary lymph node lesion was a metastasis of breast metaplastic SCC. We treated the patient with Poly ADP‐ribose Polymerase (PARP) inhibitors in combination with immune checkpoint inhibitors (ICIs) and found that she could achieve clinical benefit from the combination regimen. We reported a successful diagnosis and treatment of this rare refractory disease and reviewed the literature on the characteristics, pathogenesis, and advances in the diagnosis and treatment of breast metaplastic SCC.https://doi.org/10.1111/1759-7714.14602breast cancerdiagnosismetaplastic SCCprecision medicinetreatment |
| spellingShingle | Rilan Bai Lin Jia Yangyang Gao Xu Sun Naifei Chen Zheng Lv Jiuwei Cui Targeted therapy combined with immunotherapy in patients with breast infiltrating ductal carcinoma with axillary lymph node metastasis of metaplastic SCC Thoracic Cancer breast cancer diagnosis metaplastic SCC precision medicine treatment |
| title | Targeted therapy combined with immunotherapy in patients with breast infiltrating ductal carcinoma with axillary lymph node metastasis of metaplastic SCC |
| title_full | Targeted therapy combined with immunotherapy in patients with breast infiltrating ductal carcinoma with axillary lymph node metastasis of metaplastic SCC |
| title_fullStr | Targeted therapy combined with immunotherapy in patients with breast infiltrating ductal carcinoma with axillary lymph node metastasis of metaplastic SCC |
| title_full_unstemmed | Targeted therapy combined with immunotherapy in patients with breast infiltrating ductal carcinoma with axillary lymph node metastasis of metaplastic SCC |
| title_short | Targeted therapy combined with immunotherapy in patients with breast infiltrating ductal carcinoma with axillary lymph node metastasis of metaplastic SCC |
| title_sort | targeted therapy combined with immunotherapy in patients with breast infiltrating ductal carcinoma with axillary lymph node metastasis of metaplastic scc |
| topic | breast cancer diagnosis metaplastic SCC precision medicine treatment |
| url | https://doi.org/10.1111/1759-7714.14602 |
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