The Role of Progranulin (PGRN) in the Pathogenesis of Glioblastoma Multiforme
Glioblastoma multiforme (GBM) represents the most common and aggressive malignant form of brain tumour in adults and is characterized by an extremely poor prognosis with dismal survival rates. Currently, expanding concepts concerning the pathophysiology of GBM are inextricably linked with neuroinfla...
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MDPI AG
2024-01-01
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| author | Łukasz A. Poniatowski Michał Woźnica Piotr Wojdasiewicz Aneta Mela-Kalicka Katarzyna Romanowska-Próchnicka Daryush Purrahman Grzegorz Żurek Maciej Krawczyk Najmeh Nameh Goshay Fard Marzena Furtak-Niczyporuk Janusz Jaroszyński Mohammad-Reza Mahmoudian-Sani Ilona Joniec-Maciejak |
| author_facet | Łukasz A. Poniatowski Michał Woźnica Piotr Wojdasiewicz Aneta Mela-Kalicka Katarzyna Romanowska-Próchnicka Daryush Purrahman Grzegorz Żurek Maciej Krawczyk Najmeh Nameh Goshay Fard Marzena Furtak-Niczyporuk Janusz Jaroszyński Mohammad-Reza Mahmoudian-Sani Ilona Joniec-Maciejak |
| author_sort | Łukasz A. Poniatowski |
| collection | DOAJ |
| description | Glioblastoma multiforme (GBM) represents the most common and aggressive malignant form of brain tumour in adults and is characterized by an extremely poor prognosis with dismal survival rates. Currently, expanding concepts concerning the pathophysiology of GBM are inextricably linked with neuroinflammatory phenomena. On account of this fact, the identification of novel pathomechanisms targeting neuroinflammation seems to be crucial in terms of yielding successful individual therapeutic strategies. In recent years, the pleiotropic growth factor progranulin (PGRN) has attracted significant attention in the neuroscience and oncological community regarding its neuroimmunomodulatory and oncogenic functions. This review of the literature summarizes and updates contemporary knowledge about PGRN, its associated receptors and signalling pathway involvement in GBM pathogenesis, indicating possible cellular and molecular mechanisms with potential diagnostic, prognostic and therapeutic targets in order to yield successful individual therapeutic strategies. After a review of the literature, we found that there are possible PGRN-targeted therapeutic approaches for implementation in GBM treatment algorithms both in preclinical and future clinical studies. Furthermore, PGRN-targeted therapies exerted their highest efficacy in combination with other established chemotherapeutic agents, such as temozolomide. The results of the analysis suggested that the possible implementation of routine determinations of PGRN and its associated receptors in tumour tissue and biofluids could serve as a diagnostic and prognostic biomarker of GBM. Furthermore, promising preclinical applications of PGRN-related findings should be investigated in clinical studies in order to create new diagnostic and therapeutic algorithms for GBM treatment. |
| first_indexed | 2024-03-08T09:55:29Z |
| format | Article |
| id | doaj.art-0af7c7a5c01447f3b0c0a1e865db3584 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-08T09:55:29Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-0af7c7a5c01447f3b0c0a1e865db35842024-01-29T13:50:11ZengMDPI AGCells2073-44092024-01-0113212410.3390/cells13020124The Role of Progranulin (PGRN) in the Pathogenesis of Glioblastoma MultiformeŁukasz A. Poniatowski0Michał Woźnica1Piotr Wojdasiewicz2Aneta Mela-Kalicka3Katarzyna Romanowska-Próchnicka4Daryush Purrahman5Grzegorz Żurek6Maciej Krawczyk7Najmeh Nameh Goshay Fard8Marzena Furtak-Niczyporuk9Janusz Jaroszyński10Mohammad-Reza Mahmoudian-Sani11Ilona Joniec-Maciejak12Department of Neurosurgery, Dietrich-Bonhoeffer-Klinikum, Salvador-Allende-Straße 30, 17036 Neubrandenburg, GermanyDepartment of Spine Surgery, 7th Navy Hospital, Polanki 117, 80-305 Gdańsk, PolandDepartment of Biophysics, Physiology and Pathophysiology, Faculty of Health Sciences, Medical University of Warsaw, Chałubińskiego 5, 02-004 Warsaw, PolandDepartment of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology (CePT), Medical University of Warsaw, Banacha 1B, 02-097 Warsaw, PolandDepartment of Biophysics, Physiology and Pathophysiology, Faculty of Health Sciences, Medical University of Warsaw, Chałubińskiego 5, 02-004 Warsaw, PolandThalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Biostructure, Wrocław University of Health and Sport Sciences, I. J. Paderewskiego 35, 51-612 Wrocław, Poland2nd Department of Neurology, Institute of Psychiatry and Neurology, Sobieskiego 9, 02-957 Warsaw, PolandThalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Public Health, Faculty of Medicine, Medical University of Lublin, Chodźki 1, 20-093 Lublin, PolandDepartment of Administrative Proceedings, Faculty of Law and Administration, Maria Curie-Skłodowska University of Lublin, Marii Curie-Skłodowskiej 5, 20-031 Lublin, PolandThalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranDepartment of Experimental and Clinical Pharmacology, Centre for Preclinical Research and Technology (CePT), Medical University of Warsaw, Banacha 1B, 02-097 Warsaw, PolandGlioblastoma multiforme (GBM) represents the most common and aggressive malignant form of brain tumour in adults and is characterized by an extremely poor prognosis with dismal survival rates. Currently, expanding concepts concerning the pathophysiology of GBM are inextricably linked with neuroinflammatory phenomena. On account of this fact, the identification of novel pathomechanisms targeting neuroinflammation seems to be crucial in terms of yielding successful individual therapeutic strategies. In recent years, the pleiotropic growth factor progranulin (PGRN) has attracted significant attention in the neuroscience and oncological community regarding its neuroimmunomodulatory and oncogenic functions. This review of the literature summarizes and updates contemporary knowledge about PGRN, its associated receptors and signalling pathway involvement in GBM pathogenesis, indicating possible cellular and molecular mechanisms with potential diagnostic, prognostic and therapeutic targets in order to yield successful individual therapeutic strategies. After a review of the literature, we found that there are possible PGRN-targeted therapeutic approaches for implementation in GBM treatment algorithms both in preclinical and future clinical studies. Furthermore, PGRN-targeted therapies exerted their highest efficacy in combination with other established chemotherapeutic agents, such as temozolomide. The results of the analysis suggested that the possible implementation of routine determinations of PGRN and its associated receptors in tumour tissue and biofluids could serve as a diagnostic and prognostic biomarker of GBM. Furthermore, promising preclinical applications of PGRN-related findings should be investigated in clinical studies in order to create new diagnostic and therapeutic algorithms for GBM treatment.https://www.mdpi.com/2073-4409/13/2/124progranulinglioblastoma multiformebrain tumouroncogenesisdrug resistancetemozolomide |
| spellingShingle | Łukasz A. Poniatowski Michał Woźnica Piotr Wojdasiewicz Aneta Mela-Kalicka Katarzyna Romanowska-Próchnicka Daryush Purrahman Grzegorz Żurek Maciej Krawczyk Najmeh Nameh Goshay Fard Marzena Furtak-Niczyporuk Janusz Jaroszyński Mohammad-Reza Mahmoudian-Sani Ilona Joniec-Maciejak The Role of Progranulin (PGRN) in the Pathogenesis of Glioblastoma Multiforme Cells progranulin glioblastoma multiforme brain tumour oncogenesis drug resistance temozolomide |
| title | The Role of Progranulin (PGRN) in the Pathogenesis of Glioblastoma Multiforme |
| title_full | The Role of Progranulin (PGRN) in the Pathogenesis of Glioblastoma Multiforme |
| title_fullStr | The Role of Progranulin (PGRN) in the Pathogenesis of Glioblastoma Multiforme |
| title_full_unstemmed | The Role of Progranulin (PGRN) in the Pathogenesis of Glioblastoma Multiforme |
| title_short | The Role of Progranulin (PGRN) in the Pathogenesis of Glioblastoma Multiforme |
| title_sort | role of progranulin pgrn in the pathogenesis of glioblastoma multiforme |
| topic | progranulin glioblastoma multiforme brain tumour oncogenesis drug resistance temozolomide |
| url | https://www.mdpi.com/2073-4409/13/2/124 |
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