Poly(ester amine) Composed of Polyethylenimine and Pluronic Enhance Delivery of Antisense Oligonucleotides In Vitro and in Dystrophic mdx Mice

Poly(ester amine) Composed of Polyethylenimine and Pluronic Enhance Delivery of Antisense Oligonucleotides In Vitro and in Dystrophic mdx Mice

A series of poly(esteramine)s (PEAs) constructed from low molecular weight polyethyleneimine (LPEI) and Pluronic were evaluated for the delivery of antisense oligonuclotides (AOs), 2′-O-methyl phosphorothioate RNA (2′-OMePS) and phosphorodiamidate morpholino oligomer (PMO) in cell culture and dystro...

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Bibliographic Details
Main Authors: Mingxing Wang, Bo Wu, Jason D Tucker, Lauren E Bollinger, Peijuan Lu, Qilong Lu
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
antisense delivery
exon-skipping
muscular dystrophy
nanoparticle
polyethylenimine modification
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117300689

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