A disordered region retains the full protease inhibitor activity and the capacity to induce CD8+ T cells in vivo of the oral vaccine adjuvant U-Omp19

A disordered region retains the full protease inhibitor activity and the capacity to induce CD8+ T cells in vivo of the oral vaccine adjuvant U-Omp19

U-Omp19 is a bacterial protease inhibitor from Brucella abortus that inhibits gastrointestinal and lysosomal proteases, enhancing the half-life and immunogenicity of co-delivered antigens. U-Omp19 is a novel adjuvant that is in preclinical development with various vaccine candidates. However, the mo...

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Bibliographic Details
Main Authors: M. Laura Darriba, Celeste Pueblas Castro, Lorena M. Coria, Laura Bruno, M. Laura Cerutti, Lisandro H. Otero, Lucía B. Chemes, Rodolfo M. Rasia, Sebastián Klinke, Juliana Cassataro, Karina A. Pasquevich
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Mucosal adjuvant
Protease inhibitor
Structure-activity relationship
Protein structure
Protein crystallization
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022003889

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