Bone morphogenetic protein-induced heterotopic bone formation: What have we learned from the history of a half century?
Bone morphogenetic protein (BMP) was originally discovered by Marshall Urist a half century ago following the observation of a unique activity that induced heterotopic bone formation in skeletal muscle tissue. The molecular mechanisms underlying the induction of heterotopic bone formation in skeleta...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-05-01
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| Series: | Japanese Dental Science Review |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1882761614000295 |
| _version_ | 1828236009759834112 |
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| author | Takenobu Katagiri, PhD Kenji Osawa Sho Tsukamoto Mai Fujimoto Arei Miyamoto Takato Mizuta |
| author_facet | Takenobu Katagiri, PhD Kenji Osawa Sho Tsukamoto Mai Fujimoto Arei Miyamoto Takato Mizuta |
| author_sort | Takenobu Katagiri, PhD |
| collection | DOAJ |
| description | Bone morphogenetic protein (BMP) was originally discovered by Marshall Urist a half century ago following the observation of a unique activity that induced heterotopic bone formation in skeletal muscle tissue. The molecular mechanisms underlying the induction of heterotopic bone formation in skeletal muscle by BMPs were elucidated through the purification and molecular cloning of BMPs and identification of their functional receptors and downstream effectors, as well as from genetic disorders related to BMP activity. BMPs are important regulators of not only skeletal development and regeneration but also the homeostasis of normal skeletal muscle mass. There is still much to learn about the physiology and pathology at the interface of BMPs and skeletal muscle. |
| first_indexed | 2024-04-12T20:24:34Z |
| format | Article |
| id | doaj.art-0afb3e0bd4144f74a36848e929fe8d71 |
| institution | Directory Open Access Journal |
| issn | 1882-7616 |
| language | English |
| last_indexed | 2024-04-12T20:24:34Z |
| publishDate | 2015-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Japanese Dental Science Review |
| spelling | doaj.art-0afb3e0bd4144f74a36848e929fe8d712022-12-22T03:17:53ZengElsevierJapanese Dental Science Review1882-76162015-05-01512425010.1016/j.jdsr.2014.09.004Bone morphogenetic protein-induced heterotopic bone formation: What have we learned from the history of a half century?Takenobu Katagiri, PhD0Kenji Osawa1Sho Tsukamoto2Mai Fujimoto3Arei Miyamoto4Takato Mizuta5Division of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama 350-1241, JapanDivision of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama 350-1241, JapanDivision of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama 350-1241, JapanDivision of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama 350-1241, JapanDivision of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama 350-1241, JapanDivision of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Saitama 350-1241, JapanBone morphogenetic protein (BMP) was originally discovered by Marshall Urist a half century ago following the observation of a unique activity that induced heterotopic bone formation in skeletal muscle tissue. The molecular mechanisms underlying the induction of heterotopic bone formation in skeletal muscle by BMPs were elucidated through the purification and molecular cloning of BMPs and identification of their functional receptors and downstream effectors, as well as from genetic disorders related to BMP activity. BMPs are important regulators of not only skeletal development and regeneration but also the homeostasis of normal skeletal muscle mass. There is still much to learn about the physiology and pathology at the interface of BMPs and skeletal muscle.http://www.sciencedirect.com/science/article/pii/S1882761614000295Bone formationBMPReceptorSignal transductionSkeletal muscleDifferentiation |
| spellingShingle | Takenobu Katagiri, PhD Kenji Osawa Sho Tsukamoto Mai Fujimoto Arei Miyamoto Takato Mizuta Bone morphogenetic protein-induced heterotopic bone formation: What have we learned from the history of a half century? Japanese Dental Science Review Bone formation BMP Receptor Signal transduction Skeletal muscle Differentiation |
| title | Bone morphogenetic protein-induced heterotopic bone formation: What have we learned from the history of a half century? |
| title_full | Bone morphogenetic protein-induced heterotopic bone formation: What have we learned from the history of a half century? |
| title_fullStr | Bone morphogenetic protein-induced heterotopic bone formation: What have we learned from the history of a half century? |
| title_full_unstemmed | Bone morphogenetic protein-induced heterotopic bone formation: What have we learned from the history of a half century? |
| title_short | Bone morphogenetic protein-induced heterotopic bone formation: What have we learned from the history of a half century? |
| title_sort | bone morphogenetic protein induced heterotopic bone formation what have we learned from the history of a half century |
| topic | Bone formation BMP Receptor Signal transduction Skeletal muscle Differentiation |
| url | http://www.sciencedirect.com/science/article/pii/S1882761614000295 |
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