| Summary: | Xuecheng Tong,1,2 Zeyu Huang,1 Xiujun Zhang,1,2 Guocan Si,2 Huifen Lu,2 Wei Zhang,2 Yuan Xue,1,2 Weibin Xie3 1Institute of Hepatology, the Third People’s Hospital of Changzhou, Changzhou, People’s Republic of China; 2Department of Infectious Diseases, the Third People’s Hospital of Changzhou, Changzhou, People’s Republic of China; 3Department of Anesthesiology, the Third People’s Hospital of Changzhou, Changzhou, People’s Republic of ChinaCorrespondence: Yuan Xue; Weibin Xie, Institute of Hepatology, the Third People’s Hospital of Changzhou, No. 300 Lanling North Road, Changzhou, Jiangsu, 213000, People’s Republic of China, Tel +86 519 82009059, Email xueyuan80908@163.com; Xiewb2022@163.comObjective: Analyzing the risk factors for pneumonia development in breakthrough cases with a history of inactivated vaccine injection is important. The present study aimed to investigate the risk factors for pneumonia development during Omicron variant infection.Design and Methods: The clinical data were retrospectively collected from 187 patients who previously received inactivated vaccine and were infected by the Omicron variant.Results: Among the 187 patients, 73 had 2 doses of inactivated vaccine injection and the remaining 114 had 3 doses; 19 patients had pneumonia at admission. The univariate logistic analysis showed that age, baseline platelet count, D-dimer level, and CD8+ T lymphocyte count were associated with pneumonia development at admission. The multivariate analysis showed that only age was the independent risk factor for pneumonia development (odds ratio = 1.046, 95% confidence interval: 1.003– 1.091, P = 0.04). With an optimal cutoff value of 46, 4.4% (4/91) patients in the age < 46 years group and 15.63% (15/96) patients in the age ≥ 46 years group had pneumonia (χ2 = 6.454, P = 0.01). Moreover, age negatively correlated with CD8+ T cell count, B cell count, and albumin and uric acid levels (all P < 0.01), while age positively correlated with the glucose level (P < 0.01).Conclusion: Old age was the only independent risk factor for pneumonia development in patients with Omicron variant infection and a history of inactivated vaccine injection.Keywords: COVID-19, glucose, Omicron, pneumonia, SARS-CoV-2
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