The role of Tetraspanins in digestive system tumor development: update and emerging evidence
Digestive system malignancies, including cancers of the esophagus, pancreas, stomach, liver, and colorectum, are the leading causes of cancer-related deaths worldwide due to their high morbidity and poor prognosis. The lack of effective early diagnosis methods is a significant factor contributing to...
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| Format: | Article |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1343894/full |
| _version_ | 1797320871189151744 |
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| author | Shijie Shao Zhen Bu Jinghua Xiang Jiachen Liu Rui Tan Han Sun Yuanwen Hu Yimin Wang |
| author_facet | Shijie Shao Zhen Bu Jinghua Xiang Jiachen Liu Rui Tan Han Sun Yuanwen Hu Yimin Wang |
| author_sort | Shijie Shao |
| collection | DOAJ |
| description | Digestive system malignancies, including cancers of the esophagus, pancreas, stomach, liver, and colorectum, are the leading causes of cancer-related deaths worldwide due to their high morbidity and poor prognosis. The lack of effective early diagnosis methods is a significant factor contributing to the poor prognosis for these malignancies. Tetraspanins (Tspans) are a superfamily of 4-transmembrane proteins (TM4SF), classified as low-molecular-weight glycoproteins, with 33 Tspan family members identified in humans to date. They interact with other membrane proteins or TM4SF members to form a functional platform on the cytoplasmic membrane called Tspan-enriched microdomain and serve multiple functions including cell adhesion, migration, propagation and signal transduction. In this review, we summarize the various roles of Tspans in the progression of digestive system tumors and the underlying molecular mechanisms in recent years. Generally, the expression of CD9, CD151, Tspan1, Tspan5, Tspan8, Tspan12, Tspan15, and Tspan31 are upregulated, facilitating the migration and invasion of digestive system cancer cells. Conversely, Tspan7, CD82, CD63, Tspan7, and Tspan9 are downregulated, suppressing digestive system tumor cell metastasis. Furthermore, the connection between Tspans and the metastasis of malignant bone tumors is reviewed. We also summarize the potential role of Tspans as novel immunotherapy targets and as an approach to overcome drug resistance. Finally, we discuss the potential clinical value and therapeutic targets of Tspans in the treatments of digestive system malignancies and provide some guidance for future research. |
| first_indexed | 2024-03-08T04:49:17Z |
| format | Article |
| id | doaj.art-0afddfe3023e41e1a8582d7f6ce3e2a5 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-08T04:49:17Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-0afddfe3023e41e1a8582d7f6ce3e2a52024-02-08T05:19:59ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2024-02-011210.3389/fcell.2024.13438941343894The role of Tetraspanins in digestive system tumor development: update and emerging evidenceShijie Shao0Zhen Bu1Jinghua Xiang2Jiachen Liu3Rui Tan4Han Sun5Yuanwen Hu6Yimin Wang7Articular Orthopaedics, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaDepartment of General Surgery, Xinyi People’s Hospital, Xinyi, ChinaArticular Orthopaedics, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaArticular Orthopaedics, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaArticular Orthopaedics, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaArticular Orthopaedics, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaDepartment of Gastroenterology, Kunshan First People’s Hospital Affiliated to Jiangsu University, Kunshan, ChinaArticular Orthopaedics, The Third Affiliated Hospital of Soochow University, Changzhou, ChinaDigestive system malignancies, including cancers of the esophagus, pancreas, stomach, liver, and colorectum, are the leading causes of cancer-related deaths worldwide due to their high morbidity and poor prognosis. The lack of effective early diagnosis methods is a significant factor contributing to the poor prognosis for these malignancies. Tetraspanins (Tspans) are a superfamily of 4-transmembrane proteins (TM4SF), classified as low-molecular-weight glycoproteins, with 33 Tspan family members identified in humans to date. They interact with other membrane proteins or TM4SF members to form a functional platform on the cytoplasmic membrane called Tspan-enriched microdomain and serve multiple functions including cell adhesion, migration, propagation and signal transduction. In this review, we summarize the various roles of Tspans in the progression of digestive system tumors and the underlying molecular mechanisms in recent years. Generally, the expression of CD9, CD151, Tspan1, Tspan5, Tspan8, Tspan12, Tspan15, and Tspan31 are upregulated, facilitating the migration and invasion of digestive system cancer cells. Conversely, Tspan7, CD82, CD63, Tspan7, and Tspan9 are downregulated, suppressing digestive system tumor cell metastasis. Furthermore, the connection between Tspans and the metastasis of malignant bone tumors is reviewed. We also summarize the potential role of Tspans as novel immunotherapy targets and as an approach to overcome drug resistance. Finally, we discuss the potential clinical value and therapeutic targets of Tspans in the treatments of digestive system malignancies and provide some guidance for future research.https://www.frontiersin.org/articles/10.3389/fcell.2024.1343894/fullTetraspaninsdigestive system tumorstumor metastasisdrug resistancetherapeutic target |
| spellingShingle | Shijie Shao Zhen Bu Jinghua Xiang Jiachen Liu Rui Tan Han Sun Yuanwen Hu Yimin Wang The role of Tetraspanins in digestive system tumor development: update and emerging evidence Frontiers in Cell and Developmental Biology Tetraspanins digestive system tumors tumor metastasis drug resistance therapeutic target |
| title | The role of Tetraspanins in digestive system tumor development: update and emerging evidence |
| title_full | The role of Tetraspanins in digestive system tumor development: update and emerging evidence |
| title_fullStr | The role of Tetraspanins in digestive system tumor development: update and emerging evidence |
| title_full_unstemmed | The role of Tetraspanins in digestive system tumor development: update and emerging evidence |
| title_short | The role of Tetraspanins in digestive system tumor development: update and emerging evidence |
| title_sort | role of tetraspanins in digestive system tumor development update and emerging evidence |
| topic | Tetraspanins digestive system tumors tumor metastasis drug resistance therapeutic target |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1343894/full |
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